The Best Way to Fight Hunger Fights Terrorism As Well

The Best Way to Fight Hunger

Fights Terrorism As Well

Hunger pervades our society. Everybody experiences hunger every day. Some people experience hunger all day all night long. At least it’s thought so. Actually those who go without food don’t often experience hunger except for the ones who haven’t broken the cycle of hunger. This is a cycle that controls hunger a few hours at a time at a time. This is also addiction. This is your addiction to glucose. It works by playing with your hormones every your blood glucose levels change. When you eat carbs your glucose levels are altered, it’s this alteration of your blood glucose levels that alters the reaction of your hormones. It’s those changes in your hormones that affect your behavior, and makes you act in the manner you do. It’s those changes in hormones that also affect your hunger cycles.

This is a simple one. At least, to me, it’s simple. Actually, this may be the easiest and simplest cure for hunger that exists today. If you think it’s time for a cure for hunger, I’ve got the solution; to best fight hunger, you need to stop the hunger cycle. You need to do this not by feeding the starving people bags of flour and corn to eat, but by giving them education about nutrition and diet to get them off of the flour and corn diet. That is what makes them hungry and dependent on the grains for their diet. They will remain dependent until they either quit eating the grains, or die. The death part always comes prematurely, always. This is the addiction part of the cycle.

Since you can live better without carbs (I’m proving that), your body does not need them. That is the definition of addiction, the body requiring something it doesn’t need and manifesting discomfort when it’s not available for the affected to use. This is the same as what an alcoholic goes though when they can’t get a drink. It’s what cigarette smokers feel when they need a smoke. It’s a need that has to be satisfied, but it can only be satisfied in your mind, where your hormones affect your emotions. They affect your emotions in your mind, more than anywhere else. This is your instruction center for the body, for what happens in the body and how you react to whatever stimuli affect the body.

How Glucose Creates Terrorism

Your emotions should remain in your control, not in the control of what you eat. When you allow that to happen, you’re allowing the industry that controls what you eat, to control how you feel and what you do, by controlling your emotions. This is a cycle. It’s a cycle of dependence. It’s a cycle of dependence on the grain industry. Not the beef industry or dairy industry, simply the grain industry and its manufacturers and processors. It’s this industry that’s responsible for all glycation that occurs in your blood. It’s this industry that’s responsible for your hunger cycles and that put’s responsibility on them for your changes in emotions and behavior. It can also give them some responsibility for the terrorism that exists in the world today as it’s controlled by the amount of anger and hate that’s expressed which in turn is controlled by what controls the hate and anger and that’s a glucose diet. A diet that’s responsible for emotional changes by changing your hormones. This diet creates this hunger cycle that all who are living on a glucose diet can expect to live with. It’s the cost of a diet of carbs.

It’s not only a cycle of hunger, it’s a cycle of addiction. Every addict has to feed their addiction. When you feel hungry, what do you hunger for? What is the first thing you want to eat or drink? That tells you where your addiction lies. I know what you’re thinking right now, how can hunger to eat be an addiction? That’s the first question I’m asked, whenever I call this an addiction. This is how addictions work, they force your body to want something that it really doesn’t need. It creates discomfort in the body until that need is met. When that need is met, comfort takes place and damage internally begins. While your emotions are being controlled by your glucose infusion and making you feel comfortable, the glucose from the sugar and carbs is busy, very busy glycating whatever cholesterol or protein the glucose can find.

Those grains not only increase hunger, but they’re the prime agent behind all modern diseases caused by the creation of glycation in the blood. That’s exactly what these foods do. How they do it, right now, isn’t important. What’s important is that these foods, in the manner in which they are digested, not only create the glycation but they create hunger as well. It’s this hunger they create that makes them addictive and dangerous to the point of deadly.

It has to do with the fluctuation of your hormones due to your diet of grains. Once grains are ground, they lose their fiber. This is important because it’s the fiber that slows down the breakdown of the sugars in the grains that influence your blood glucose. The slower those sugars are introduced into your system, the slower they raise your blood glucose. Most diabetics know this, as it’s the quick rise in blood glucose that is responsible for the glycation and the release of hormones that disrupt the normal functions of the body. This is what drives the hunger cycle. This is what makes everyone hungry. My theory is to eliminate this cycle, and to eliminate the cycle, means changing the equation, the equation of digestion. The best way to change that equation is to changes the factors of the equation, in this case one factor. All you have to do to cure hunger and glycation is to remove carbohydrates from the equation and thus the diet. The solution is that simple. Maybe not easy, but simple.

When one considers the fact that the primary driver of hunger is a carbohydrate diet, it’s easy to see that the solution for hunger is to eliminate the hunger of hunger by changing the diet. Taking carbohydrates out of the diet removes the hunger factor and thus the hunger cycle. Anyone doubting this can go on the diet that I’ve been on for three years and they’ll know. Three years on the diet that I’ve been on will not only convince anyone of this concept, it will also improve their health in unimaginable ways. The last time I got hungry was 3 yrs 2 weeks ago. That was when I broke my addiction to glucose. Others who are on this diet will tell you the same thing, they don’t get hungry and the reason they don’t get hungry is that they don’t have the glucose going through their systems to create the hunger cycle.

Because this is an addiction, those who still eat carbs, can’t see. You have to break the addiction to know this. That’s the way it is with any addiction, you can’t see it while you’re in it. Yet, almost everyone knows that sugar is addictive. I think because nobody wants to equate that sugar with carbs, they don’t want to fully grasp that the carbs they were told they need, is sugar. Carbs,something your were told you have to have, breaks down to the exact same thing as sugar, and that’s glucose. Yet, they’re still telling everyone to eat whole grains. Maybe it’s always been spoken of in that manner because it seemed to justify our need for it. That, my friends, is the definition of co-dependent and I think you know what that deals with, when co-dependency deals with a substance,  Well here’s your news flash; sugar including carbs, is addictive. That means that carbs are an addictive food to eat. It’s also deadly, deadlier than alcohol, deadlier than heroin, than cigarettes and drug addiction. Sugar addiction is responsible for ECC, Excessive Carbohydrate Consumption. ECC is the deadliest addiction a person can have. It’s responsible for over 2000 deaths every day in the US alone. That number jumps to over 50,000 worldwide (daily). I can guarantee a manifestation of disease causing AGEs to anyone who consumes a diet of grains. How much they consume will dictate how much glycation they get to deal with, but they will deal with it, guaranteed. The manner in which you cure the glycation will also cure the hunger. What it does is to wipe out the hunger cycle (and it does it altogether), it also does to the glycation cycle. That is how you cure hunger. That is also how you conquer and cure all modern diseases. You can do it in one fell swoop. This is exciting.

To me, the cure for hunger is the same cure for all the modern diseases that are responsible for over 2000 deaths every day. If you cure one, you cure the other. That will go miles to cure the problem of hunger around the world. We need to stop supplying the world with our killing field grains. It’s the hunger that proves the addictive nature of carbs. Once you break the addiction, you lose the hunger cycle and without a cycle to create your hunger, the hunger can’t exist. Hunger is then cured. You just have to solve the problem of too many people going without nutritious food and being subjected to a diet of non-nutritious food, which includes the category of grains.

It’s the cycle of hunger that’s responsible not only for growth, but also for all harm done in the name of growth  or progress, as well as advancement, or security, or improvement Those are all desires driven by the cycle of hunger. It’s this cycle of hunger that drives these emotions. Deep down inside, you know this to be true. After you eat, when you blood sugars are at their highest, you are at one of your most relaxed attitudes of the day. The only other times you feel this secure is right after you eat any meal or snack (unless you’re consciously cheating on a diet and are dealing with guilt issues). This is the high side of the cycle, this is when you feel that everything is OK, “my stomach is full and I don’t feel like I need anything except to sit here and relax for a minute. This is how you feel at the end of Thanksgiving Dinner, Christmas Dinner, New Years Day dinner, Easter Dinner, etc, etc, etc. This is also the end of every meal you eat, to some extent. This is the glucose hitting your blood stream, waiting to give you fuel for energy. This is also the start of glycation and the hunger cycle.

It’s the start of glycation because all that glucose you just put into your blood by eating your starchy grains, is now floating all through your blood after being broken down to glucose, starting with the saliva in your mouth. That means that before it hits your stomach, your blood glucose levels are reacting. This is the start of the hunger cycle to which there is no end, until you stop feeding it. When your blood glucose levels fall and your stomach starts to shrink just a little bit after the digestion of your meal, that triggers your stomach to release Ghrelin, your hunger hormone. That’s the hormone that nobody on a carbohydrate diet can resist. That’s because many of those on a carb diet, must satisfy that Ghrelin hormone. Once they get hungry they feel the need to satisfy their hunger usually with some form of carbohydrate more than anything else. This is the low side of the cycle that drives people to abhorrent behavior because of their need. This hunger and satiety cycle influences almost every other cycle our bodies go through. It’s what drives all human behavior, of those that are on a carbohydrate diet. This is the cycle that drives people into the use and abuse, of social media to slander, attack, and accuse without evidence, others they disagree with. As the Late Gwen Ifill said, “we have to guard against how we treat each other”. I noticed it was cancer that took Gwen from us.

This manner in how we treat each other is one of the reasons why I’m writing this post about what this food source that Monsanto has given us to eat is doing to everyone who eats it. Up until I watched Food, inc, (Monsanto only played a small part in my equation. I didn’t realize they were behind this to the extent that they actually are. I now see that they are a much larger part of it than I expected.)

What their grains do with their glycating destruction starts with premature aging. It does that by driving fat production and the glycation factor that influences all modern disorders. That figures into everything glycation plays a factor in. Glycation is another name for inflammation. I know this. I’ve experienced the release from the addiction. The evidence in my books prove this. I know why we behave like the society that we do. It has to do with what we eat.

Nobody will believe me until they heed my advice and kick their own addiction. Only then, can they see the true light. I can guarantee the light you’ll see is a light of freedom, true freedom. Freedom from the  cycle of hunger that drives virtually every other cycle. If you can eliminate this cycle, you can eliminate everything this cycle creates and drives, starting with obesity and diabetes and moving on to glycation. That will go far to improve not only health, but mental attitudes, and hence better emotional outcomes and less strife. That is true freedom, freedom from the cycle of hunger, freedom from the cycle of addiction. Freedom from the wild roller coaster ride of emotional swings. The freedom I experience is true freedom as this cycle does not affect anybody on a purely ketogenic diet. We’re not subject to the hunger cycle that the carb diet requires. By the same token, we’re not subject to the glycation cycle of destruction either. This cycle is also at the root of all violence and terrorism, as it subject to the same hormone changes that control your emotions, as explained above. These emotions are just slightly altered because of their influence from the glucose fluctuations in your blood.

To control the glucose fluctuations, the easiest way is to control what feeds the cycle. That means to control the cycle you need to control the introduction of glucose into your body. Controlling the flow of sugars (carbs and fructose) is the only way you can control the blood glucose fluctuations. As easy as this may sound, that may be furthest from the truth. Controlling the inflow of carbs into your body is as difficult as fighting any addiction, because that’s exactly what you’re doing, fighting an addiction. That’s also why you must break the addiction, addictions kill prematurely and you can live without this addictive food.

This brings me to the conclusion that a ketogenic diet is the optimal diet for a society to be following for the best health of the society. The ketogenic diet not only removes the hormonal control out of the equation, it removes glycation out of the equation. That makes it a truly win, win diet for everyone to follow.

The problem here is sticking to a ketogenic diet. We’ll cover that here because it’s not only important, it’s vital to convert to the ketogenic diet to save yourself and our society as a whole. This is also how curing hunger can also cure terrorism by curing abhorrent behavior by removing your emotions from the hunger cycle. This removal of your emotions from the hunger cycle has multiple other benefits for your emotional behavior. It puts those emotions back in your control and not the control of the industry that promotes them. It also return other emotional control you’d thought you’d lost years ago. The control you lost was a relinquish of control to the industry that has addicted you. This isn’t your fault. You’ve always eaten carbs and sugar. They were considered healthy at one time. That again is because of their addictive nature.

In order to be able to stick to a ketogenic diet does that does mean breaking the addiction. Once it’s broke, you’ll know it and you’ll know it firmly, distinctly. It’s a feeling I still remember clearly, three years later. It’s a feeling of freedom. It’s a feeling of freedom from dependence on a substance that is as satisfying as it as dangerous. That is what makes it so dangerous, the fact that is so satisfying, so satiating, so hormonal fluctuating. That makes it also emotionally fluctuating. That makes it prone to emotional outbursts and terrorism. If you control your emotions and not let what you eat control them, that gives you more control over your emotional reactions and the consequences of those emotional reactions. This is a small synopsis of the control that glucose has on your actions and reactions. I being on a ketogenic diet do not experience this control of my emotions or actions or reactions due to glucose influence. I’ve learned how to live without that influence. I learned that three years, two weeks ago. It may have been the best day in my life. But I have to admit that sticking to a ketogenic diet is difficult to get into. It took me over two years to transform to the diet I’ve been on since I started writing my books. One thing I know, is that I could have never accomplished this without being on this diet. It’s not only overcome severe chronic pain, but it’s also over come pre-diabetic conditions as well as high blood pressure, chronic constipation from the drugs that were prescribed, near obesity, and brain drain, more than anything else. Being on my ketogenic diet has sharpened my brain to a point I wish it could have been when I was in school.  Boy, would my life have been different.

This is why I want to help you succeed at your attempt to convert, it’s that important for our society, if we’re to end hunger and terrorism. In order to do that I recommend to stop buying everything that raises your blood glucose more than 50 pts on the glycemic index. This will keep your blood glucose levels from reaching glycating or hunger cycling proportions. This is the starting point that I used when I started three years ago. I cut out bread first. That was the hardest because that included everything that flour is used in. To do otherwise is not giving up the bread. After the magic came from giving up the bread, I switched those calories to calories from higher fiber carbs like vegetables and fresh fruit. I was still reluctant to put dairy in my diet then, as I still have some Almond Milk in my fridge, I didn’t realize it then because my knowledge hadn’t grown to the point to where I decided to go completely ketogenic, so I was still putting more sugar in my body than what I am now, where I’m experiencing the improvements in my mental functions as well as my physical abilities.  I’m actually healing my paralysis, little by little. My fight side is actually getting more functional every day that I remain on this diet,

That is why I decided to convert to a completely keto diet after two years of simply a low carb diet. That may have got me to my weight goal, but it wasn’t getting me my brain back. Quitting bread prompted me to quit all grains and starchy carbohydrates like potatoes and beans. That felt so great, I decided to go completely keto approximately one year ago. That’s when I started my website and started writing all the information that I’m packing into three books. If anyone else were doing this I would think it phenomenal. But because it’s myself doing this, I’m just driven to get this information our there where the public can see it. Killing my mother has become my driving force to get this known. My ability to accomplish this working in a state of paralysis, to me is phenomenal. for that I have to thank Dr Perlmutter, Thank you Dr Perlmutter, I couldn’t have done this without your book or advice.

For those who want something to kill? I’ve got something for you to kill. Kill your hunger cycle. Kill it before it kills you first. Monsanto may have different ideas, though. Their profits depend on your hunger cycle. Their drug industry depends on your hunger cycle. Your hunger cycle drives you to eat more and more carbs to satisfy that hunger cycle. If you want to kill something worth killing, kill your hunger cycle and do it as quick as you can. The following report from Wikipedia shows why;

The influence of funding on research and the management of conflicts of interests as explained from The New England Journal of Medicine (Aug 19, 1993)

“Conflict of interest” in the field of medical research has been defined as “a set of conditions in which professional judgment concerning a primary interest (such as a patients welfare or the validity of research) tends to be unduly influenced by a secondary interest (such as financial gain).”]

In the early 1900s private companies such as the Carbolic Smoke Ball Company,[15] Mrs. Winlow’s Soothing Syrup[16]among other snake medicine remedies were solicited around the world and were the cause of many deaths due to misinformation. Information was not readily available to consumers nor was it required of the pharmaceutical producers to inform their customers of the ingredients that they were consuming. Samuel Hopkins Adams was an investigator to uncover the wide corruption and falsehoods that existed within the American pharmaceutical industry. He is quoted saying: “Gullible America will spend this year some seventy-five millions of dollars in the purchase of patent medicines. In consideration of this sum it will swallow huge quantities of alcohol, an appalling amount of opiates and narcotics, a wide assortment of varied drugs ranging from powerful and dangerous heart depressants to insidious liver stimulants; and far in excess of all other ingredients, undiluted fraud.”[15]

Regulation on industry funded biomedical research has seen great changes since Samuel Hopkins Adams declaration. In 1906 congress passed the Pure Food and Drugs Act of 1906.[16] In 1912 Congress passed the Shirley Amendment to prohibit the wide dissemination of false information on pharmaceuticals.[16] The Food and Drug Administration was formally created in 1930 under the McNarey Mapes Amendment to oversee the regulation of Food and Drugs in the United States.[16] In 1962 the Kefauver-Harris Amendments to the Food, Drug and Cosmetics Act made it so that before a drug was marketed in the United States the FDA must first approve that the drug was safe.[16] The Kefauver-Harris amendments also mandated that more stringent clinical trials must be performed before a drug is brought to the market.[15]The Kefauver-Harris amendments were met with opposition from industry due to the requirement of lengthier clinical trial periods that would lessen the period of time in which the investor is able to see return on their money. In the pharmaceutical industry patents are typically granted for a 20-year period of time, and most patent applications are submitted during the early stages of the product development.[15]According to Ariel Katz on average after a patent application is submitted it takes an additional 8 years before the FDA approves a drug for marketing.[15] As such this would leave a company with only 12 years to market the drug to see a return on their investments. After a sharp decline of new drugs entering the US market following the 1962 Kefauver-Harris amendments economist Sam Petlzman concluded that cost of loss of innovation was greater than the savings recognized by consumers no longer purchasing ineffective drugs.[15] In 1984 the Hatch-Waxman Act or the Drug Price Competition and Patent Term Restoration Act of 1984 was passed by congress.[16] The Hatch-Waxman Act was passed with the idea that giving brand manufacturers the ability to extend their patent by an additional 5 years would create greater incentives for innovation and private sector funding for investment.[17]

The relationship that exists with industry funded biomedical research is that of which industry is the financier for academic institutions which in turn employ scientific investigators to conduct research. A fear that exists wherein a project is funded by industry is that firms might negate informing the public of negative effects to better promote their product.[15] A list of studies show that public fear of the conflicts of interest that exist when biomedical research is funded by industry can be considered valid after a 2003 publication of “Scope and Impact of Financial Conflicts of Interest in Biomedical Research” in The Journal of American Association of Medicine. This publication included 37 different studies that met specific criteria to determine whether or not an academic institution or scientific investigator funded by industry had engaged in behavior that could be deduced to be a conflict of interest in the field of biomedical research. Survey results from one study concluded that 43% of scientific investigators employed by a participating academic institution had received research related gifts and discretionary funds from industry sponsors.[11]Another participating institution surveyed showed that 7.6% of investigators were financially tied to research sponsors, including paid speaking engagements (34%), consulting arrangements (33%), advisory board positions (32%) and equity (14%).[11] A 1994 study concluded that 58% out of 210 life science companies indicated that investigators were required to withhold information pertaining to their research as to extend the life of the interested companies’ patents.[11] Rules and regulations regarding conflict of interest disclosures are being studied by experts in the biomedical research field to eliminate conflicts of interest that could possibly affect the outcomes of biomedical research.

This is almost a definition of what Monsanto has accomplished in the last 40 years and they seem to be doing their level best to increase their power. It’s their food that glycates your blood. It’s their food that addicts you to eat more and more of their food. It’s their food that creates the hunger cycle that drives your behavior. It’s this company that is forcing farmers to grow their seed to grow the crops to put on your table to eat. That means that it’s this company that is responsible for over 45,000 deaths every day from ECC, Excessive Carbohydrate Consumption. ECC is the deadliest addiction mankind has ever experienced. It’s Monsanto who’s infiltrated their execs into the offices of the USDA and the FDA the government departments that control all the agencies and offices within them.

This has given them unprecedented control over what goes in our mouths to eat. That has given them full control over the diseases and disorders all who eat their food will acquire. That is something I can virtually guarantee. Why? It lies in the science of a glucose diet, the deadliest diet now that a man can use.

Thank you Monsanto :(

USDA’s Encouragement of Current Health Crisis

USDA’s Encouragement of Current Health Crisis

With the same co-mingling of execs and offices of the USDA and Monsanto, as between the FDA and Monsanto, Monsanto has set itself up to be producer and regulator in full control over all of the food that we are forced to put on our tables. That is if you’re forced to eat at a restaurant or buy food at a grocery store. If you’re one of those people, your food is more than likely, a product of Monsanto. It’s also a product of Monsanto’s chemicals, chiefly their herbicide Roundup, a glyphosate herbicide that inhibits how enzymes work in the environment as well as your body.

That wouldn’t be so bad if Monsanto didn’t force all farmers to grow their crop seed each and every year.  That gives them full control over every muffin you sink your teeth into, even those bran muffins, the ones that are supposed to be so healthy.

What Monsanto knows that they’re not telling the USDA, is that the corn, wheat and soy beans that their farmers grow for us are at the root of most all glycation that occurs in the body. What they’re afraid of the USDA knowing, is that this glycation is at the root of all modern diseases, from atherosclerosis to hypertension, from arthritis to IBS or irritable bowel syndrome, to dementia including Alzheimer’s disease and Parkinson’s disease. All of these diseases and disorders are treated by the drug industry that Monsanto owned as well. That’s what’s scary…very scary. The company that’s responsible for your food is the same company that treats you for the ailments their food brings. To me that’s criminal. Now, Bayer wants to buy out Monsanto. What do you think that will do to your food supply? Bayer is a German company, you know.

Monsanto doesn’t want either the USDA or the FDA to be too aware of what their food does, yet all of the studies mentioned above are available through PubMed. If I have access to these studies, I know they do as well. What I don’t know is what do they refuse to look at them? They only have to look at a few. I found two or three damning studies on the first page of search returns for the term, glycation. Glycation has a nasty tendency to muck up everything in the body that blood affects. Monsanto doesn’t want the USDA or the FDA to realize this.  Their practice of striving for total control over our food source drives the profits of their crop seed companies, (of which they’re dozens). Having that control over our food gives them control over our drug use, as it’s their food that makes us sick. That makes us require their medications to treat the disease their food gives those who eat it.

They’ve tried denying that their food is as dangerous as it is by publishing their own research reports showing different results that “prove” their food is healthy, when it’s not. It’s obvious that they don’t want this information known by either the USDA or the FDA. Fortunately for Monsanto, they already have they own retired execs running the FDA and the USDA. Apparently it’s not in their best interest to make this information known to the public. I’m sure they fear the consequences of their actions, for producing a food this dangerous. I would be if I were them.

With all the agencies the USDA has control over, it’s no wonder that they can’t see that the food they recommend we eat, has had more studies done on the glycation of it, than any other food. We’ve learned that glycation is the real poisoning of America, and with glycation being involved in every modern disease known to man (simply because of the glycation is causes), glycation is something that our food industry should be working to stem as it’s this glycation that’s at the root of all “modern” diseases.

FYI fact: There were 50,000 food safety inspections in 1972. That was reduced to just over 9,000 in 2008.

If there were only 9000 in 2008, reduced from 50,000 in 1972, when the threat level was much lower, the FDA is only succeeding at failing us on a unprecedented basis. I’m sure this is due to funding cutbacks from the government but I’m also sure it involves something related to departmental offices being run by corporate management brought in from corporations they’re supposed to regulate, proving once again that money talks and (unfortunately) the bottom line is what wins here and the bottom line is greed. If the USDA and the FDA can allow a food this dangerous through its monitoring, I’m afraid to even think about what else has snuck through?  The beef industry has already displayed their contempt for regulation through the mass production of beef that their industry is responsible for, especially in the last 30 years. (Including that beef that’s imported from Paraguay, the most GMO soy loaded feed made for feed lots.) That’s a whole other story about how this industry is ruining the lives in our South American neighbor by poisoning their crops and the lives of their farmers. This is just so you can have cheap beef.

According to their Website, USDA.gov their agencies and offices include the following (I’m listing all of them so you’ll know the enormity of this agency). It has to be enormous, 19 agencies and 17 offices, all designed to protect you. You health is at stake and a majority of this Departments’ agencies and offices are failing to keep your food safe for consumption.

AGENCIES:

 

Agricultural Marketing Service (AMS)

AMS facilitates the strategic marketing of agricultural products in domestic and international markets while ensuring fair trading practices and promoting a competitive and efficient marketplace. AMS constantly works to develop new marketing services to increase customer satisfaction. It’s responsible for developing quality grade standards for agricultural commodities, administering marketing regulatory programs, marketing agreements and orders, and making food purchases for USDA food assistance programs.

Program and Service Highlights:

Agricultural Transportation

Country of Origin Labeling

Farmers Market

Farmers Market Promotion Program

Federal-State Marketing Improvement Program

Food Purchases

Grade Standards

Local Food Marketing

Market News Reports

National Organic Program

 

I have to wonder if they check the quality and safety of the grain they’re approving for consumption, whether it’s for livestock feed or human consumption. Are they aware that what they’re approving is contaminated? I’m curious as to how they grade this substandard grain that’s putting so many people in the hospital? Evidently they not detecting the Roundup that’s it’s laden with.

Agricultural Research Service (ARS)

 

ARS is USDA’s principal in-house research agency. ARS leads America towards a better future through agricultural research and information.

(ARS) works to ensure that Americans have reliable, adequate supplies of high-quality food and other agricultural products. ARS accomplishes its goals through scientific discoveries that help solve problems in crop and livestock production and protection, human nutrition, and the interaction of agriculture and the environment.

Programs and service highlights:

National Research

International Research

Research Partnerships and Technology

Research Locations

National Agricultural Library

 

The question I’d like to ask this department is how much research do you pay attention to when you recommend what food to eat. Does your research cover the effects of grains after they’ve been consumed? They claim to be interested in nutrition. Are they? Or are they interested in their own bottom line with their stock options with Monsanto?

Animal and Plant Health Inspection Service (APHIS)

APHIS provides leadership in ensuring the health and care of animals and plants. The agency improves agricultural productivity and competitiveness and contributes to the national economy and the public health.

(APHIS) is responsible for protecting and promoting U.S. agricultural health, administering the Animal Welfare Act, and carrying out wildlife damage management activities.

Programs and service highlights:

Cattle Disease Information

Plant Health Import Permits

Plant Export Certificates and Forms

Animal Health Permits

Animal and Animal Product Export Information

Wood Packaging Material

 

Center for Nutrition Policy and Promotion (CNPP)

 

CNPP works to improve the health and well-being of Americans by developing and promoting dietary guidance that links scientific research to the nutrition needs of consumers.

(CNPP) works to improve the health and well-being of Americans by developing and promoting dietary guidance that links scientific research to the nutrition needs of consumers.

Programs and service highlights:

ChooseMyPlate

MyPlate Blast Off Game and Information for Children

SuperTracker and Other Tools

Dietary Guidelines for Americans

Healthy Eating Index

Nutrition Insights

These are the offices that are supposed to ensure that the food you eat on a daily basis, no matter where it comes from or where you buy it (grocery store or restaurant), is going to keep you healthy. Have you ever considered the value of their work or the quality of the food they approve for your table? With the high rates of Atherosclerosis, cancer, inflammatory diseases and dementia, it appears that they are failing on a massive scale.

(Unless you were looking at it from a corporate point of view where this is an investors dream, this is a consumer’s nightmare.) Regardless of how unscrupulous this is, it’s going to continue to happen as long as this agency recommends the consumption of these foods.

Myplate.gov, which is administered by the CNPP, has replaced the food pyramid for our dietary guidelines. Myplate.gov is now our dietary guidelines and it still insists that grains remain a part of our diet. I’ve asked them about this and have received one reply from someone who didn’t even know what glycation is or what it is responsible for. I’m still waiting for my reply for that and another email I’ve not so recently sent them.

 

 

Economic Research Service (ERS)

ERS is USDA’s principal social science research agency. Each year, ERS communicates research results and socioeconomic indicators via briefings, analyses for policymakers and their staffs, market analysis updates, and major reports. (ERS) provides economic research and information to inform public and private decision making on economic and policy issues related to agriculture, food, natural resources, and rural America. Through a broad range of products, ERS research provides not only facts, but also expert economic analysis of many critical issues facing farmers, agribusiness, consumers, and policymakers. ERS expertise helps these stakeholders conduct business, formulate policy, or just learn about agriculture, food, natural resources, and rural America.

Programs and service highlights:

Food and Nutrition Assistance

Food Safety

Farm Sector Income & Finances

Food Markets and Prices

Natural Resources and Environment

Agricultural Markets and Trade

Rural Communities and Development

Farm and Commodity Policy

Agricultural R&D and Productivity

Amber Waves Magazine

State Fact Sheets

Commodity Outlook Reports

 

These are the offices regulate the safety of our food. I wonder if they are aware of the dangers of grains in the food supply. One would think that they are, but with 109 people dying every hour, I have to wonder.

 

Farm Service Agency (FSA)

The Farm Service Agency implements agricultural policy, administers credit and loan programs, and manages conservation, commodity, disaster and farm marketing programs through a national network of offices. (FSA) administers farm commodity, crop insurance, credit, environmental, conservation, and emergency assistance programs for farmers and ranchers.

Programs and service highlights:

Farm Loan Programs

Disaster Assistance

Price Support

Conservation Programs

Daily Market Prices

Commodity Procurement

This is the agency that watches over the farmer and their needs and concerns. Their interest doesn’t concern the safety of the food we eat or how nutritious it is. They’re simply concerned about the farmer’s ability to grow it. They offer the assistance programs that help fund the industry.

 

Food and Nutrition Service (FNS) 

 

FNS increases food security and reduces hunger in partnership with cooperating organizations by providing children and low-income people access to food, a healthy diet, and nutrition education in a manner that supports American agriculture and inspires public confidence. (FNS) administers the food and nutrition assistance programs in the U.S. Department of Agriculture. FNS provides children and needy families with better access to food and a more healthful diet through its programs and nutrition education efforts.

Programs and service highlights:

Women, Infant, and Children (WIC) Program

Supplemental Nutrition Assistance Program

School Meals

Food Distribution Programs

Disaster Assistance

Child and Adult Care Food Program

Summer Food Service Program

Farmers Markets Nutrition Programs

Nutrition Education

 

This is the agency that makes sure the disadvantaged have an adequate food supply. One of their major concerns is to distribute the grains that are used in our food supply to those who don’t have the ability to purchase their own. This ensures that everyone who lives in this disadvantaged lifestyle doesn’t get the proper nutrition they need to sustain healthy living and in turn, makes them dependant on the pharmaceutical industry for their future health. Don’t forget that pharmaceuticals only lead to more and ultimately more pharmaceuticals. This is the never-ending cycle if dependence that this industry wants to keep the public in. This cycle is at the government expense though, and that means that we, the taxpayer get to foot the bill.

It’s too bad that they don’t realize to conquer hunger you must first conquer the hunger cycle. If the USDA read any of the reports in the PubMed or PMC archives, they’d know that it’s the grains and sugar in the diet that create hunger cycle more than anything else. If you were on a ketogenic diet, you could see the logic in this statement, to stop hunger you have to stop the hunger cycle.

This is where their logic is flawed; they think that feeding hungry people grains to fill their bellies will take care of the hunger. It won’t, it will only make them hungrier; it’s the law of carbohydrate consumption, it a continuous hunger cycle that you’re really condemning them to.  You’re also condemning them to a lifetime of medication need.

 

Food Safety and Inspection Service (FSIS)

FSIS enhances public health and well-being by protecting the public from food borne illness and ensuring that the nation’s meat, poultry and egg products are safe, wholesome, and correctly packaged. (FSIS) is the public health agency in the U.S. Department of Agriculture responsible for ensuring that the nation’s commercial supply of meat, poultry, and egg products is safe, wholesome, and correctly labeled and packaged, as required by the Federal Meat Inspection Act, the Poultry Products Inspection Act, and the Egg Products Inspection Act.

Program and Service Highlights;

Food Safety Education

Science

Regulations and Policies

Food Recalls

Food Defense and Emergency Response

Fact Sheets

Ask Karen

If this agency had anything to do with the production of sugar and grains, I’d be in contact with them. But they don’t.

It appears that this following agency ensures that the poison we grow in the US makes its way around the world to infect as many people as possible.

 

Foreign Agricultural Service (FAS)

FAS works to improve foreign market access for U.S. products. This USDA agency operates programs designed to build new markets and improve the competitive position of U.S. agriculture in the global marketplace. (FAS) is responsible for collecting, analyzing, and disseminating information about global supply and demand, trade trends, and market opportunities. FAS seeks improved market access for U.S. products; administers export financing and market development programs; provides export services; carries out food aid and market-related technical assistance programs; and provides linkages to world resources and international organizations.

Program and Service Highlights;

Trade News

Trade Policy

Commodity Information

Country Information

Export Programs

Food Aid Programs

Attache Reports

Export Sales Reports

North American Free Trade Agreement (NAFTA) Information

U.S.-Central America-Dominican Republic Free Trade Agreement (CAFTA-DR)

This may be done to ensure the viability of the pharmaceutical industry, as all of those grains foods can only lead to more pharmaceutical needs. If you can spread this problem around the world, what do you think that would do for your profit margin, if you’re a pharmaceutical company? (Evidently Monsanto thinks the same way.) Maybe that’s why we shouldn’t allow anyone with corporate ties in any way, to work in any of our regulatory agencies. That would mean that government employees couldn’t own any corporate stock. I wonder how many do today. Do you think that could constitute any conflicts in interest?

 

Forest Service (FS)

FS sustains the health, diversity and productivity of the Nation’s forests and grasslands to meet the needs of present and future generations. (FS) administers programs for applying sound conservation and utilization practices to natural resources of the national forests and national grasslands, for promoting these practices on all forest lands through cooperation with states and private landowners, and for carrying out extensive forest and range research.

Program and Service Highlights;

Fire Information

Maps and Brochures

Passes and Permits

Forest Inventory and Analysis

Forest Health Protection

Recreational Activities

Research & Development

 

This agency protects undeveloped land and has no control over what goes on your table. It’s the following agency that I have issues with as they inspect the grain that’s responsible for all this damage.

 

Grain Inspection, Packers and Stockyards Administration (GIPSA)

 

GIPSA facilitates the marketing of livestock, poultry, meat, cereals, oilseeds, and related agricultural products. It also promotes fair and competitive trading practices for the overall benefit of consumers and American agriculture. GIPSA ensures open and competitive markets for livestock, poultry, and meat by investigating and monitoring industry trade practices.

Programs and service highlights;

Federal Grain Inspection and Weighing Services

International Service Programs

Regulated Entities under the Packers and Stockyards Act

Packers and Stockyards Program (P&SP) Enforcement Actions

Federal Grain Inspection Service (FGIS) Providers

FGIS Handbooks and Publications

FGIS Forms

P&SP Forms

Directives and Notices

GIPSA Violation Hotline

Official U.S. Standards for Grain

Contact GIPSA

 

I doubt this agency even knows what they’re approving when they approve this grain for consumption. If they did, they wouldn’t allow this to slip right past their noses without smelling anything rotten?

 

National Agricultural Library (NAL)

NAL ensures and enhances access to agricultural information for a better quality of life. (NAL) provides technical information on agricultural research and related subjects to scientists, educators and farmers using computer databases; coordinates and is primary resource for national network of state land grant university and field libraries; and serves as the U.S. center for the international agriculture information system.

Program and Service Highlights;

Agricultural Online Access (AGRICOLA)

Agriculture Network Information Center (AgNIC)

Alternative Farming Systems Information Center (AFSIC)

Animal Welfare Information Center (AWIC)

Digital Desktop (DigiTop) for Employees

Food and Nutrition Information Center (FNIC)

Food Safety Research Information Office

Healthy Meals Resource System

National Invasive Species Information Center (NISIC)

Nutrition.gov

Rural Information Center

SNAP-Ed Connection (formerly Food Stamp Nutrition Connection)

Water Quality Information Center

WIC Works Resource System

 

One would think with all the departments in this agency, at least one would understand the dangers of grains. It may not be a problem of whether or not any one knows about it, it may be a problem of anybody caring enough to do anything about it.

 

National Agricultural Statistics Service (NASS)

NASS serves the basic agricultural and rural data needs of the country by providing objective, important and accurate statistical information and services to farmers, ranchers, agribusinesses and public officials. This data is vital to monitoring the ever-changing agricultural sector and carrying out farm policy. (NASS) is responsible for conducting monthly and annual surveys and preparing official USDA data and estimates of production, supply, prices, and other information necessary to maintain orderly agricultural operations. NASS also conducts the census of agriculture which is currently conducted every 5 years.

Program and Service Highlights

Today’s Reports

Quick Stats – Query Database by Commodity, State, and Year

Census of Agriculture

Crop Weather by State

Agricultural Charts and Maps

Agricultural Statistics by Year

Statistics by Subject

Calendar of NASS Reports

 

I wonder if any of their statistics show the impact that this food has had on our society as a whole, in the way it’s influenced the health and medical industries with the boom of business it’s created for the pharmaceutical industry. Does the government understand that the more they support the industrial GMO farming in this case, the more it’s costing them having to treat people for the disorders that this industry is imposing upon those who buy into it? How many people do you know that didn’t have their toast or bagel this morning? How many of those do you think will go without a sandwich at lunch?

This is not a small problem. It exists everywhere. This is the result of politically engineering your food supply by the industry that supplies it. This is the result of self policing. Our problem is, it’s created a land of sugar junkies clamoring for their next hit, wherever they can find it. (It’ll probably be the next drive through.) You unwittingly buy right into this with every Big Mac you buy. That comfort you’re buying now leads only to huge amounts of discomfort in the very near future. I’ll start with headaches and stomach aches. It’ll end with your body’s choice of disease starting with atherosclerosis and Alzheimer’s, and ending with cancer or cardiovascular disease. This is a cycle that must change.

I add my name to the list of many trying to get the FDA and the USDA to act on this concern. Spearheading this list were Dr William Davis and Dr David Perlmutter in 2010 and 2012, with their books Wheat Belly  and Grain Brain.  They are still trying to right this wrong. After being on both sides of this argument and experiencing all the pain that the other side has to offer, I know for a fact that the only avenue out of this dilemma, is to go to a paleo or ketogenic diet. I just wish the FDA and the USDA could understand this.

 

National Institute of Food and Agriculture (NIFA)

NIFA’s unique mission is to advance knowledge for agriculture, the environment, human health and well-being, and communities by supporting research, education, and extension programs in the Land-Grant University System and other partner organizations. NIFA doesn’t perform actual research, education, and extension but rather helps fund it at the state and local level and provides program leadership in these areas. (NIFA) is an agency within the U.S. Department of Agriculture (USDA), part of the executive branch of the Federal Government. Congress created NIFA through the Food, Conservation, and Energy Act of 2008. NIFA replaced the former Cooperative State Research, Education, and Extension Service (CSREES), which had been in existence since 1994.

I clicked on the research Link to find that they’re pretty proud of their involvement in peanut research, claiming that; North Carolina A&T research makes peanuts safer to eat.

Maybe if they were to stop and realize that peanuts, like all legumes are grains, they would understand that like grains, peanuts ultimately break down to glucose. They’re just not cereal grains, so they inflict the harm slower, but they still have the capacity to inflict harm. Because they’re harder to digest and do have more fiber than the starchy cereal grains, they impact the glycemic load much less, which is what keeps the blood glucose more even over time. Any doctor will tell you that will make you healthier. The problem is, healthier in this case, is still unhealthy.

 

I submit that it’s not peanuts that create the allergic reaction, It’s the glucose. Like celiac disease with wheat, peanut allergies operate the same way because they ultimately break down to glucose and then to methylglyoxal, the most glycating substance the body creates from carbs. I contend that it’s in this substance that causes the allergic reaction. (If it weren’t for glucose, the lac operon in your genome could recognize all lactose that you consume, but because of this lac operon, your gut bacteria can’t recognize the lactose because it sees the glucose. It rejects the lactose making people allergic to lactose, when in all actuality; it’s the glucose that’s creating the problem.) Where is the warning for glucose? And where’s the warning fructose as well for that matter? It glycates, almost as much, as glucose.

 

Natural Resources Conservation Service (NRCS)

 

NRCS provides leadership in a partnership effort to help people conserve, maintain and improve our natural resources and environment. (NRCS) is the primary federal agency that works with private landowners to help them conserve, maintain and improve their natural resources. The Agency emphasizes voluntary, science-based conservation; technical assistance; partnerships; incentive-based programs; and cooperative problem solving at the community level.

 

This is the agency responsible for the treatment of our environment including the lands and waters that create it. I found that their concern is mostly with conservation and soil health. My concern is in the growing of non essential grains and feeding them to an unsuspecting society. I included this agency only because it is a small part in this whole complex algorithm. I haven’t checked on their relationship with the EPA is though. I’m sure that they would be happy not having to check toxin levels in the soil with the loss of spraying Roundup. I can only imagine the headaches this herbicide has given them (those not owned by Monsanto).

Risk Management Agency (RMA)

RMA helps to ensure that farmers have the financial tools necessary to manage their agricultural risks. RMA provides coverage through the Federal Crop Insurance Corporation which promotes national welfare by improving the economic stability of agriculture. (RMA) promotes, supports, and regulates sound risk management solutions to preserve and strengthen the economic stability of America’s agricultural producers by providing crop insurance to American producers, developing and the premium rate, administering premium and expense subsidy, approving and supporting products, and reinsuring companies.

 

It’s a shame crop insurance doesn’t cover the damage the crops do to the consumer. Where’s that kind of crop insurance? In a keto diet!

Rural Development (RD)

RD helps rural areas to develop and grow by offering Federal assistance that improves quality of life. RD targets communities in need and then empowers them with financial and technical resources. USDA Rural Development is committed to the future of rural communities. Our role is to increase rural residents’ economic opportunities and improve their quality of life. Rural Development forges partnerships with rural communities, funding projects that bring housing, community facilities, utilities and other services. We also provide technical assistance and financial backing for rural businesses and cooperatives to create quality jobs in rural areas. Rural Development promotes the President’s National Energy Policy and ultimately the nation’s energy security by engaging the entrepreneurial spirit of rural America in the development of renewable energy and energy efficiency improvements. Rural Development works with low-income individuals, State, local and Indian tribal governments, as well as private and nonprofit organizations and user-owned cooperatives.

Program and Service Highlights

Business Programs

Community Development Programs

Cooperative Programs

Housing and Community Facilities Programs

Renewable Energy and Energy Efficiency Improvements Program

Rural Utilities Service

Water and Waste Disposal Loan and Grant Program

 

This agency’s concern is the viability of rural communities, probably in an attempt not to allow rural towns to become ghost towns, which is already beginning to happen where industrial farming is taking place. With the new industrial farming that’s done today, fewer farmers are living in rural areas to support these rural communities. This is industrial farming according to the Monsanto creed. I shouldn’t need to ask you why this is allowed to happen. What I will ask is, what would happen if the grain industry transformed into a healthier industry? It would have to be one that didn’t involve polluting the environment with herbicides and pesticides and creating food that is responsible for all modern disease imposed upon modern man. It would have to include a withdrawal from industrial farming, A lack of the need for all the grain we consume would curtail this problem immensely. We need to bring back the small farmer.

Departmental Management (DM)

DM provides central administrative management support to Department officials and coordinates administrative programs and services. Departmental Management is USDA’s central administrative management organization. Departmental Management provides budget and fiscal management, human resource, procurement and information technology support to mission areas so that they can serve customers more effectively and efficiently. Departmental Management manages the Headquarters Complex and provides direct customer service to Washington, D.C. employees.

Program and Service Highlights

Be Prepared – USDA Employee Information Center

Sustainable Operations – USDA Sustainability Efforts

Office of Small and Disadvantaged Business Utilization

TARGET Center

USDA Vendor Outreach Program

Judicial Decisions

Contract Appeal Decisions

Alternative Fuel Vehicle (AFV) Program

Workplace Violence Prevention

 

If this department’s job is to coordinate interdepartmental management and cooperation, is it their responsibility to disseminate the information from the reports in PubMed, PMC, and the FDA with their agency that recommends what should be in our diet? Have they educated the people at MyPlate.gov about the warnings that have been coming from PubMed and PMC about the dangers of what they’re recommending everyone to consume on a regular basis? Whole grains are still recommended in every agency and association that has a diet recommendation. Even Myplate.gov and the American Dietary Association and, believe it or not, the American Diabetic Association still recommend whole grains should be a part of a healthy diet. What health grains bring is, by far, counterbalanced by the harm they inflict.

National Appeals Division (NAD)

NAD conducts impartial administrative appeal hearings of adverse program decisions made by USDA and reviews of determinations issued by NAD hearing officers when requested by a party to the appeal. (NAD) is responsible for all administrative appeals arising from program activities of the Farm Service Agency, Risk Management Agency, Natural Resources Conservation Service, Rural Business-Cooperative Development Service, Rural Housing Service, and the Rural Utilities Service.

Program and Service Highlights

Appeal Process

E-Guide to Filing an Appeal

How to Make a FOIA Request

Statutes and Regulations

Search for Decisions

 

The appeal that I’d like to file would be to appeal the decision to approve grains for human consumption. They’re inadequate as animal feed due to all the herbicides and pesticides in them, yet they still recommend them as human food. This is unconscionable.

OFFICES

Office of Advocacy and Outreach (OAO)

The Office of Advocacy and Outreach (OAO) was established by the 2008 Farm bill to improve access to USDA programs and to improve the viability and profitability of small farms and ranches; beginning farmers and ranchers and socially disadvantaged farmers or ranchers. OAO develops and implements plans to coordinate outreach activities and services provided by the Department through working collaboratively with the field base agencies and continually assessing the effectiveness of its outreach programs.

Improving the viability and profitability of small and beginning farmers and ranchers Improving access to USDA programs for historically underserved communities Improving agricultural opportunities for farm workers

Closing the professional achievement gap by providing opportunities to talented and diverse young people to support the agricultural industry in the 21st century

 

If it’s this department’s responsibility to ensure the small farmer’s growth, why are they allowing Monsanto to take over all farming in the USA? A healthy food supply cannot be supplied by a monopoly as big as Monsanto. Are they familiar with the contracts Monsanto requires their contracted farmers to sign? Are they familiar with to movement Monsanto is making to control 100% or our food supply? Are they aware of the holdings of the Monsanto execs in the drug industry that used to be owned by Monsanto? I’m sure their breakup did not leave anybody without stock options.

 

Office of the Assistant Secretary for Civil Rights (OASCR)

OASCR’s mission is to facilitate the fair and equitable treatment of USDA customers and employees, while ensuring the delivery and enforcement of civil rights programs and activities. ASCR ensures compliance with applicable laws, regulations, and policies for USDA customers and employees regardless of race, color, national origin, sex (including gender identity and expression), religion, age, disability, sexual orientation, marital or familial status, political beliefs, parental status, protected genetic information, or because all or part of an individual’s income is derived from any public assistance program. (Not all bases apply to all programs.)

 

Office of Budget and Program Analysis (OBPA)

OBPA provides centralized coordination and direction for the Department’s budget, legislative and regulatory functions. It also provides analysis and evaluation to support the implementation of critical policies. OBPA administers the Department’s budgetary functions and develops and presents budget-related matters to Congress, the news media, and the public.
Office of the Assistant Secretary for Civil Rights ensures compliance with applicable laws, regulations, and policies for USDA customers and employees regardless of race, color, national origin, sex (including gender identity and expression), religion, age, disability, sexual orientation, marital or familial status, political beliefs, parental status, protected genetic information, or because all or part of an individual’s income is derived from any public assistance program. (Not all bases apply to all programs.)

Program and Service Highlights

Program Discrimination Complaints

Office of the Assistant Secretary for Civil Rights

Early Resolution and Conciliation

 

If this department is interested in civil rights, then I have a complaint for them right now. My rights have been violated, by this food being imposed upon me, by making sure it’s in my baby food, and anything I want to drink (except for plain water), and everything I want to eat. I didn’t ask for this but it causes a lot of discomfort for me and everyone else who eats it. All of our rights were violated in serving this food to us without our consent or approval.

Office of the Chief Economist (OCE)

OCE advises the Secretary on the economic situation in agricultural markets and the economic implications of policies and programs affecting American agriculture and rural communities. OCE serves as the focal point for economic intelligence and analysis related to agricultural markets and for risk assessment and cost-benefit analysis related to Departmental regulations affecting food and agriculture. (OCE) advises the Secretary on the economic implications of policies and programs affecting the U.S. food and fiber system and rural areas as well as coordinates, reviews, and approves the Department’s commodity and farm sector forecasts.

Program and Service Highlights

World Agricultural Outlook Board (WAOB)

Office of Risk Assessment and Cost Benefit Analysis

Climate Change Program Office

Sustainable Development

Agricultural Labor Affairs

Office of Energy Policy and New Uses

Weather and Climate

Office of Environmental Markets

If this office is to oversee the offices affecting the food and fiber system, what’s happened to the regulation regarding the use of pesticides and herbicides on crops? Is there none?

Office of the Chief Financial Officer (OCFO)

OCFO shapes an environment for USDA officials eliciting the high-quality financial performance needed to make and implement effective policy, management, stewardship, and program decisions. (OCFO) provides financial leadership for USDA, which administers $100 billion of loans as well as significant guarantees and insurance in support of America’s farmers and ranchers.

Program and Service Highlights

USDA Budget

USDA Performance and Accountability Report

USDA Strategic Plan

National Finance Center (NFC)

Employee Personal Page

Financial Management Modernization Initiative (FMMI)

 

I wonder how many loans they’ve given that have benefited the industrial farming side of this equation. Are they helping to promote this huge industrial farming that’s detrimental not only to the environment, but to our food supply? How can that be to our benefit?

Office of the Chief Information Officer (OCIO

OCIO has the primary responsibility for the supervision and coordination of the design, acquisition, maintenance, use, and disposal of information technology by USDA agencies. OCIO’s strategically acquires and uses information technology resources to improve the quality, timeliness and cost-effectiveness of USDA services.

Program and Service Highlights

Directives

Enterprise Architecture

Enterprise IT Solutions

Enterprise Network Services

Forms Management

Governance and Strategic Investment (GSI)

Information Collection

IT Capital Planning & Investment Control

IT Security

Quality of Information Guidelines

Records Management

Section 508

This is the IT dept of the USDA. My question for this dept, does their information collection include reports from PubMed and PMC for educational purposes for recommending diets through Myplate.gov?

Office of the Chief Scientist (OCS)

OCS provides scientific leadership to the Department by ensuring that research supported by and scientific advice provided to the Department and its stakeholders is held to the highest standards of intellectual rigor and scientific integrity. It also identifies and prioritizes Department-wide agricultural research, education, and extension needs. (OCS) was established in accordance with the Food, Conservation, and Energy Act of 2008 to provide strategic coordination of the science that informs the Department’s and the Federal government’s decisions, policies and regulations that impact all aspects of U.S. food and agriculture and related landscapes and communities.

OCS advises USDA’s Chief Scientist and the Secretary of Agriculture in the following areas of science:

Agricultural Systems and Technology

Animal Health and Production, and Animal Products

Plant Health and Production, and Plant Products

Renewable Energy, Natural Resources, and Environment

Food Safety, Nutrition, and Health

Agricultural Economics and Rural Communities

 

Our work supports larger goals of scientific prioritization and coordination across the entire Department through which federal agencies provide Senior Advisors to serve in a detail capacity within OCS. We identify, prioritize and evaluate Department-wide agricultural research, education, and extension needs. In addition, the Office of the Chief Scientist regularly convenes a USDA Science Council to further facilitate cross-Departmental scientific coordination and collaboration.

 

That is directly from their website. To me that says that they ensure information gets from one department to another department, yet they seemed to have missed the reports from PubMed and PMC pointing to the damage grains do, especially wheat.

From a PDF document on nutrition, Executive Summary: National Nutrition Research Roadmap (2016-2021) I found this paragraph;

For Q3T1 (Assessing Dietary Exposures), ARS scientists recognize there is a strong need for biomarkers of intake, nutrient status, and health, and are working in multiple areas related to this. For example, ARS scientists are studying the association of vitamin K with reduced cardiovascular disease and the amounts and types of dietary fatty acids that influence immunity and inflammation. There is also a need for development of more objective measures of food intake and physical activity. To that end, scientists are testing electronic capture devices that require no input from the user and can download to databases. I can tell them right now, that fatty acids are very important for immune functions. I’ve found those studies in my research. If that’s what I found, I’m sure that’s what they’ll find. I also found that all inflammation that exists is because of glucose in the blood. I wonder how long it will be until they realize that all inflammation is influenced by one thing more than anything else? I can tell them with full confidence that glucose influences inflammation more than anything else. I know because I limit my inflammation by limiting my carb intake and nothing else has worked as well. I can also tell them through experience that exercise and dietary reduction of starches, (which they still recommend to be 25% of the diet) will go further than any vitamin. I wonder how long it will take this chief scientist to realize that glycation is at the root of all inflammation and that glucose is at the root of all glycation. It doesn’t take any kind of a scientist to see that if you removed the glucose from the equation, the product of the equation couldn’t exist. The product in this equation is all the diseases created by inflammation.

 

Office of Communications (OC)

OC is USDA’s central source of public information. The office provides centralized information services using the latest, most effective and efficient technology and standards for communication. It also provides the leadership, coordination, expertise, and counsel needed to develop the strategies, products, and services that are used to describe USDA initiatives, programs, and functions to the public. (OC) provides leadership, expertise, counsel, and coordination for the development of communications strategies which are vital to the overall formulation, awareness and acceptance of USDA programs and policies, and serves as the principal USDA contact point for the dissemination of consistent, timely information.

Program and Service Highlights

Creative Media and Broadcast Center

Brand, Events, Exhibits, and Editorial Review

Digital Communications

Photography Services

Printing Services

Radio News

The dissemination of consistent, timely information, is what this office’s responsibility is, yet I’ve not heard anything from them about the information from over 11,750 studies recording the dangers of glycation, which is the result of glucose interference with  your body’s normal processes. With studies showing this glycation going back over 30 years (about as old as GMO seeds), why hasn’t any of this “timely information” been disseminated for 30 years? Is this due to the Monsanto influence? If any agency is not fulfilling their responsibilities to keep the public safe from their own food, it’s this one. They have access to the same studies that I and thousands of others do, yet they still choose to ignore them. They still choose to recommend that this poisonous food be a part of your diet. Why?

Office of Congressional Relations (OCR)

OCR serves as the USDA’s liaison with Congress. OCR works closely with members and staffs of various House and Senate Committees to communicate the USDA’s legislative agenda and budget proposals. (OCR) serves as the Department’s liaison with Members of Congress and their staffs. OCR works closely with members and staffs of various House and Senate Committees including the House Agriculture Committee and the Senate Committee on Agriculture, Nutrition, and Forestry to communicate USDA’s legislative agenda and budget proposals. Within OCR is the Office of External and Intergovernmental Affairs (EIA) which serves as the liaison to elected and appointed officials of State, county, local, and Tribal governments. The office also serves as a liaison to USDA stakeholders.

 

My question to this office, have your alerted Congress of the dangers of these grains and the consequences they bring to the human physiology when consumed? Are you afraid of laws being passed that might outlaw some of this insanity? The insanity that I refer to is the insanity of buying into this glucose ruse, orchestrated by one of the most unscrupulous companies to ever conduct business. Is this the office responsible for keeping this information hidden from our lawmakers’ eyes? Is this the office that should be held accountable for our current state of public health? The state of our current public health is obese and diabetic, leading to carcinogenic and atherosclerotic, all because of the inflammatory nature of glycation.

If I can learn this myself and I have a good deal of brain damage inhibiting my learning ability, why can’t this office learn this to alert our Congress of this problem? The problem exists only for the consumer, as it’s a boom for Monsanto and its industries. Why would they want to control this? For them, this is good business. This is what attracts stockholders.

Office of Ethics (OE)

The Office of Ethics (OE) is the centralized office responsible for coordinating and implementing USDA’s Ethics program throughout the Department. OE provides ethics services to employees at all levels of USDA concerning advice and training about compliance with ethics laws and regulations, including the conflict of interest and impartiality rules, as well as the rules governing political activity by Federal employees.

 

A visit to this office’s site brought me to a page that showed me;

 

THE STOCK ACT

On April 4, 2012, the President signed the Stop Trading on Congressional Knowledge Act or STOCK Act (S. 2038), which amended the Ethics in Government Act of 1978 (5 U.S.C. App. § 101 et seq.) The Act has several different provisions, some of which are effective immediately, some which become effective 90 days after enactment, some which become effective on August 31, 2012, and some which do not become effective until 18 months after enactment. The following compendium of ethics laws, regulations and guidelines govern Executive Branch employees’ conduct, including USDA employees. The Department promulgated its own supplemental ethics regulation (5 CFR Part 8301) in 2006 to augment the Office of Government Ethics’ Standards of Ethical Conduct. The Department’s ethics regulation and other selected ethics laws and regulations are accessible from this page for ready reference (click on “General Ethics Laws and Regulations” below).

Overviews

Ethics Issuances

General Ethics Laws and Regulations

USDA Supplemental Ethics Regulations

 

Financial Disclosure

Fundraising & the CFC

Gifts

Holiday Guidance for Federal Personnel

Letters of Support, Recommendation, Collaboration, etc.

Lobbying

Non-Federal Organizations

Outside Employment

Political Activity

Post Employment and Seeking Employment

Procurement Integrity

Special Government Employees (SGEs)

STOCK Act

Travel & Non-Federal Assistance

 

I wonder what their ethic regulations say about recommending poisonous food to remain in our diet, when there is proof of this food’s glycative effects in over 10,000 studies in PubMed and PMC. What do their ethics say about falsifying information disseminated to the public? The still claim that whole grains are safe to eat.

 

Office of Environmental Markets (OEM)

OEM supports the development of emerging markets for carbon, water quality, wetlands, and biodiversity. (OEM) provides leadership in the development of emerging markets for carbon, water quality, wetlands, and biodiversity. OEM is building national environmental market infrastructure, supporting regional market innovation, and fostering collaboration around market-based conservation within USDA and across the federal government.

 

I wonder if this environmental market infrastructure includes more fields of these killing field grains? If so, they may want to re-assess their goals, if they intent to protect the public and the environment.

Office of the Executive Secretariat (OES)

OES ensures that all Department officials are included in the correspondence drafting and policy-making process through a managed clearance and control system. Keeping policy officials informed of executive documents enhances the Secretary’s ability to review sound and thought out policy recommendations before making final decisions. (OES) ensures that all Department officials are included in the correspondence drafting and policy making process through a managed clearance and control system. Keeping policy officials informed of executive documents enhances the Secretary’s ability to review sound and thought out policy recommendations before making final decisions. Did this office miss the memo on glycation; its causes and effects? Do they need another one? Is it their responsibility that so few know about this? Are these the people we should hold accountable?

 

Faith-Based and Neighborhood Partnerships (FBNP)

USDA has a long history of working with faith-based and community organizations to help those in need, by providing federal assistance through domestic nutrition assistance programs, international food aid, rural development opportunities, and natural resource conservation.

 

This is the office that coordinates churches food banks to assist the needy. Every church I’ve been to has had one, and they all give out plenty of bread, the deadliest of foods that we can give anyone. This condemns these poor unsuspecting souls to lives of poor health and continued medication. Our food supply is inundated with this vile product, only because it’s the primary bringer of people to medication, medication for pain.

Office of the Inspector General (OIG)

OIG investigates allegations of crime against the Department’s program, and promotes the economy and efficiency of its operations. (OGC) is an independent legal agency that provides legal advice and services to the Secretary of Agriculture and to all other officials and agencies of the Department with respect to all USDA programs and activities.

 

There were 50,000 food safety inspections in 1972. That was reduced to just over 9,000 in 2008. If there were only 9000 in 2008, reduced from 50,000 in 1972, when the threat level was much lower, the FDA is only succeeding at failing us on an unprecedented basis. I’m sure this is due to funding cutbacks from the government but I’m also sure it involves something related to departmental offices being run by corporate management brought in from corporations they’re supposed to regulate, proving once again (unfortunately) the bottom line is what wins here and the bottom line is greed.

If the USDA and the FDA can allow a food this dangerous through its monitoring, I’m afraid to even think about what else has snuck through?  The beef industry has already displayed their contempt for regulation through the mass production of beef that their industry is responsible for, especially in the last 30 years.

Office of the General Counsel (OGC)

The Office of the General Counsel (OGC) is an independent legal agency that provides legal advice and services to the Secretary of Agriculture and to all other officials and agencies of the Department with respect to all USDA programs and activities.

 

I wonder how many lawsuits this agency is going to have to fight for advising the public to eat food that’s as dangerous as whole grains. Myplate.gov still has them at 25% of our diet. Why?

Office of Tribal Relations (OTR)

The Office of Tribal Relations is located in the Office of the Secretary, and is responsible for government-to-government relations between USDA and tribal governments.

 

I can only empathize with this office as they have to see that this garbage is provided to tribal governments as well as the public in general.

I listed all of their offices and agencies for a reason. I wanted to show you the vastness of this department. It’s huge. It has to be huge to protect our food supply. As big as it is, it’s not doing that. It’s not doing its job. It’s been hijacked by the industry that it’s supposed to control. The proof lies in the extent of which disease exists today.

With all of these agencies and offices, I’m sure it’s quite difficult to keep all this information straight for the public to fully understand what this agency is allowing to “fall through the cracks”, as in allowing grains and sugar to be recommended food for everyone to eat, sometimes even those who have celiac disease. What this agency doesn’t understand is that everyone has an intolerance to the gluten than comes in grains. It’s estimated that 95% of the population have some sort of intolerance to the gliadin and gluten found in most cereal grains, especially wheat, barley and rye.

I’ve already contacted the Center for Nutrition Policy and Promotion0 (CNPP) to ask them why they still recommend including grains in the diet. They’ve come to their senses when it comes to sugar, why can’t they, with grains, they’re just as deadly as sugar, if not more so? The agency above is responsible for recommending our diet at My Plate and I’ve already asked them why they still recommend a food that can cause as much damage is this food does. I’m waiting for their reply.

There is absolutely no reason for these foods to still be recommended except for the fact that to decrease the consumption of these food would irreparably harm Monsanto and the farming industry that they control. And they control a huge portion of it.

The infiltration of their old execs and lobbyists into the offices of the FDA and the USDA is evidence indicating their complicity in the matter. With their old personnel working the offices and agencies of the USDA and the FDA, they’ve cleared a pathway to their full control over what goes on your table. This in return gives them control over the meds you’ll be buying from them in the near future.

I noticed that there is no agency or office to review and disseminate the information in these research studies showing the damaging effects of the food they’re recommending for us to eat. There’s supposed to be one, but there isn’t.

How do they make recommendations on what foods are good for you to eat, when you’re ignoring all the studies that say otherwise? They rely on Monsanto to tell them what’s healthy and what isn’t. Is that a source you would trust? I hope so because you trust them with every bagel you put in your mouth.

Monsanto’s Field of disease and discomfort

GARBAGE IN GARBAGE OUT

 IT’S WHAT YOU EAT THAT GIVES YOU GOUT

EAT THE STUFF THAT CAN’T SUSTAIN

ALL YOU GET IS ALL YOUR PAIN

LIVING WITH ADDICTION BRINGS

ALL DISORDER WITH WHICH WRINGS

AGEs TO FORCE THAT MEDICATION

THAT WILL DEFINITELY END YOUR VACATION

WITH ALL THAT’S WROUGHT BY INFLAMMATION

ALL BROUGHT ON WITH THE GLYCATION

ALL AMPLIFIED BY GLYPHOSATION

AND NAUGHT FOR ANY OF OUR SALVATION

Glycation – The Real Poisoning of America

The Real Poisoning of America – Glycation

Of the causes of death below from Wikipedia, Ischaemic heart disease @ 7.4 million ranks right at the top. This is the result of glycation, 5 of the following 8 are also caused by non-enzymatic glycation. Hence my proposal, control the glycation and you control all modern diseases.

According to Wikipedia;

It is estimated that of the roughly 150,000 people who die each day across the globe, about two thirds—100,000 per day—die of age-related causes because they have aged prematurely. Glycation is responsible for aging and the more of that, that you allow to happen in your body, the quicker your age. That is why keeping glycation to a minimum is what’s going to help you live longer and healthier. Even though aging may not be able to be reversed completely, it can be slowed dramatically by eating the right diet.  (Deep down you know that to be true. It’s just so hard to stick to when you have to.)

Leading causes of preventable death worldwide as of the year 2001, according to researchers working with the Disease Control Priorities Network (DCPN) and the World Health Organization (WHO). (The WHO’s 2008 statistics show very similar trends.) Imagine what they are right now, 8 years later and what they will be eight years from now, if nothing is done about it. Think it might be time for a cure?

The top 10 causes of preventable death, ones influenced by glycation are in red. Although it may me difficult to stop all glycation in the body, due to its commonality, you can control a major portion of it. Excessive Carbohydrate Consumption, the primary cause of glycation is controllable. Failure to control your consumption leads directly to any of the following disorders in red ;

  1. Ischaemic heart disease @ 7.4 mil
  2. Stroke@ 6.7 mil
  3. COPD @ 3.1 mil
  4. Lower Respiratory infection @ 3.1mil
  5. Trachea bronchus, lung infection@1.6 mil
  6. HIV/AIDS@1.5 mil
  7. Diarrheal diseases@1.5 mil
  8. Diabetes mellitus@1.5 mil
  9. Road injury@1.3 mil
  10. Hypertension@1.1 mil

40% of these deaths or 16.7 million are directly linked to ECC, Excessive Carbohydrate Consumption, making them the most preventable causes of death. 16.7 million deaths each and every year amounts to over 45,750 people each and every day. That includes approximately 1830 Americans each and every day. We have full control of this. All it would take is to say no to the sugar and grain industries. This one response would allow over 1830 more Americans to stay alive, every day. The cessation of carb consumption could add an additional 10-20 years to their lives, simply by eliminating the primary cause of inflammation, glucose. The continuation of carb consumption will, by contrast, prove the destructive power of sugar, by eventually killing its hosts.

Glycation is a common everyday experience that you accelerate with a carbohydrate diet. The more carbs you eat, the more glycation you’ll get to deal with. Glycation is controllable by controlling what you put in your mouth to eat. Although not totally responsible for some of these cancers, they would not exist if the glycation didn’t exist. This is the basis of my contention that if you eliminate the reason for the glycation, you eliminate the reason for inflammation, which in turn will eliminate the reason for these diseases, thereby eliminating the disease. It’s really not hard to see, once you take a good look at it; carb consumption is responsible for the inflammation that builds in the blood that is responsible for 90% of all modern diseases. Remove the inflammation by removing the sugar, which means removing the carbs. A simpler solution doesn’t exist and this cure can be yours.

These Are the Smoking Gun Articles Of

Evidence That The FDA Are Ignoring.

They’re Putting Your Health and Life at Risk.

48 of the 11667 studies done on glycation are below. These research studies were chosen from 231 studies that I examined for evidence of what glycation does to the body. By going through only 7% of these studies, I was able to find enough damning evidence to condemn this food 31 times over. By this ratio, I’ll end up finding at the least 850 more studies showing damage that glycation does.

I chose to search glycation because I know that it’s at the root of all modern diseases from cancer to CVDs to arthritis to dementia including Alzheimer disease. The following studies are the proof of what glycation does, and with sugar being the primary instigator of glycation, removal of sugar from the diet will eliminate everything it’s responsible for. These AGEs are responsible for all modern diseases and thus, are the reason for this book. When you eat carbs, you need to know what those carbs do to your body.

Foundation of Glycation

The study that piqued my interest initially was the report on RAGEs,

This report can be found on PubMed at Receptor for advanced glycation endproductsmediated inflammation and diabetic vascular complications. It explains how glycation turns your body’s fuel (cholesterol) and proteins (hemoglobin) into AGEs before they can be used for fuel and body repair.

“Exposure of amino residue of proteins to reducing sugars, such as glucose, glucose 6‐phosphate, fructose, ribose and intermediate aldehydes, results in non‐enzymatic glycation, which forms reversible Schiff bases and Amadori compounds. A series of further complex molecular rearrangements then yield irreversible advanced glycation end‐products (AGE). The aldehydes, highly reactive AGE precursors, are produced by both enzymatic and non‐enzymatic pathways. The enzymatic pathways include a route of myeloperoxidase in inflammatory cells, such as activated macrophages, which produces hypochlorite, then reacting with serine to generate glycolaldehyde.” Study Link

I’d be willing to bet that you had no idea that carb consumption is behind Amyotrophic Lateral Sclerosis (ALS). Guess what? it is. Here is your proof that MCT fats are beneficial in combating ALS;

  • Metabolic Therapy with Deanna Protocol Supplementation Delays Disease Progression and Extends Survival in Amyotrophic Lateral Sclerosis (ALS) Mouse Model

also known as Lou Gehrig’s disease, is a neurodegenerative disorder of motor neurons causing progressive muscle weakness, paralysis, and eventual death from respiratory failure. There is currently no cure or effective treatment for ALS. Besides motor neuron degeneration, ALS is associated with impaired energy metabolism, which is pathophysiologically linked to mitochondrial dysfunction and glutamate excitotoxicity. The Deanna Protocol (DP) is a metabolic therapy that has been reported to alleviate symptoms in patients with ALS. In this study we hypothesized that alternative fuels in the form of TCA cycle intermediates, specifically arginine-alpha-ketoglutarate (AAKG), the main ingredient of the DP, and the ketogenic diet (KD), would increase motor function and survival in a mouse model of ALS (SOD1-G93A). ALS mice were fed standard rodent diet (SD), KD, or either diets containing a metabolic therapy of the primary ingredients of the DP consisting of AAKG, gamma-aminobutyric acid, Coenzyme Q10, and medium chain triglyceride high in caprylic triglyceride. Assessment of ALS-like pathology was performed using a pre-defined criteria for neurological score, accelerated rotarod test, paw grip endurance test, and grip strength test. Blood glucose, blood beta-hydroxybutyrate, and body weight were also monitored. SD+DP-fed mice exhibited improved neurological score from age 116 to 136 days compared to control mice. KD-fed mice exhibited better motor performance on all motor function tests at 15 and 16 weeks of age compared to controls. SD+DP and KD+DP therapies significantly extended survival time of SOD1-G93A mice by 7.5% (p = 0.001) and 4.2% (p = 0.006), respectively. Sixty-three percent of mice in the KD+DP and 72.7% of the SD+DP group lived past 125 days, while only 9% of the control animals survived past that point. Targeting energy metabolism with metabolic therapy produces a therapeutic effect in ALS mice which may prolong survival and quality of life in ALS patients.

 What does that say about what the grain industry has told you about milk fat? They’ve condemned milk fats when they’re the healthiest fats you can eat. What the industry doesn’t like is that milk fats keep you from needing drugs, something the industry doesn’t want you to know.
Arthritis is a Result of Glycation From Inflammation

The following report is the evidence of glucose’s involvement in arthritis. By being responsible for glycation, the glucose from broken carbs, again, is directly responsible for arthritis, just like if was in the 4,000 yr old ice mummy recovered from a receding glacier.

 “Glycated, oxidized and nitrated proteins and amino acids were detected in synovial fluid and plasma of arthritic patients with characteristic patterns found in early and advanced OA and RA, and non-RA, with respect to healthy controls. In early-stage disease, two algorithms for consecutive use in diagnosis were developed: (1) disease versus healthy control, and (2) classification as OA, RA and non-RA. “  Study Link

Alzheimer’s and Parkinson’s – a Result of Glycation

The following report shows the effects that AGEs have on the body in the diseases it promotes.

“Vast evidence supports the view that glycation of proteins is one of the main factors contributing to aging and is an important element of etiopathology of age-related diseases, especially type 2 diabetes mellitus, cataract and neurodegenerative diseases. Counteracting glycation  can therefore be a means of increasing both the lifespan and health span. In this review, accumulation of glycation products during aging is presented, pathophysiological effects of glycation are discussed and ways of attenuation of the effects of glycation are described, concentrating on prevention of glycation. The effects of glycation and glycation inhibitors on the course of selected age-related diseases, such as Alzheimer’s disease, Parkinson’s disease and cataract are also reviewed.”   Study Link

This study looks at the damaging effects of glycation along with the protective effects of certain phytochemicals (anti-oxidant producing agents).

“Reducing sugars can react non-enzymatically with amino groups of proteins and lipids to form irreversibly cross-linked macroprotein derivatives called as advanced glycation end products (AGEs). Cross-linking modification of extracellular matrix proteins by AGEs deteriorate their tertiary structural integrity and function, contributing to aging-related organ damage and diabetes-associated complications, such as cardiovascular disease (CVD). Moreover, engagement of receptor for AGEs, RAGE with the ligands evoke oxidative stress generation and inflammatory, thrombotic and fibrotic reactions in various kinds of tissues, further exacerbating the deleterious effects of AGEs on multiple organ systems. So the AGE-RAGE axis is a novel therapeutic target for numerous devastating disorders. Several observational studies have shown the association of dietary consumption of fruits and vegetables with the reduced risk of CVD in a general population. Although beneficial effects of fruits and vegetables against CVD could mainly be ascribed to its anti-oxidative properties, blockade of the AGE-RAGE axis by phytochemicals may also contribute to cardiovascular event protection. Therefore, in this review, we focus on 4 phytochemicals (quercetin, sulforaphane, iridoids, and curcumin) and summarize their effects on AGE formation as well as RAGE-mediated signaling pathway in various cell types and organs, including endothelial cells, vessels, and heart.”

Glycation, Amyloid Plaque and Neurodegenerative Disorders

This report examines the nature of amyloid plaque and glyoxal (Glyoxal is an inflammatory compound formed when cooking oils and fats are heated to high temperatures). It’s also made in your body when you body breaks down glucose.

“Glyoxal, a highly reactive α-oxoaldehyde, increases in diabetic condition and reacts with proteins to form advanced glycation end products (AGEs). In the present study, we have investigated the effect of glyoxal on experimental rat hemoglobin in vivo after external administration of the α-dicarbonyl compound in animals. Gel electrophoretic profile of hemolysate collected from glyoxal-treated rats (32mg/kg body wt. dose) after one week exhibited the presence of some high molecular weight protein bands that were found to be absent for control, untreated rats. Mass spectrometric and absorption studies indicated that the bands represented hemoglobin. Further studies revealed that the fraction exhibited the presence of intermolecular cross β-sheet structure. Thus glyoxal administration induces formation of high molecular weight aggregates of hemoglobin with amyloid characteristics in rats. Aggregated hemoglobin fraction was found to exhibit higher stability compared to glyoxal-untreated hemoglobin. As evident from mass spectrometric studies, glyoxal was found to modify Arg-30β and Arg-31α of rat hemoglobin to hydroimidazolone adducts. The modifications thus appear to induce amyloid-like aggregation of hemoglobin in rats. Considering the increased level of glyoxal in diabetes mellitus as well as its high reactivity, the above findings may be physiologically significant.

In view of its inflammatory function in innate immunity and its ability to detect a class of ligands through a common structural motif, rage is often referred to as a pattern recognition receptor.”     Study link

This report examines the relationship of high mobility group box 1 (HMGB1) and the effects it has on the body. HMGB1 is one of the most prevalent RAGE’s, as near as I can tell. It comes up in more studies…

RAGE and Inflammation
·        HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia.

Infectious and sterile inflammatory diseases are correlated with increased levels of high mobility group box 1 (HMGB1) in tissues and serum. Extracellular HMGB1 is known to activate Toll-like receptors (TLRs) 2 and 4 and RAGE (receptor for advanced glycation end products) in inflammatory conditions. Here, we find that TLR5 is also an HMGB1 receptor that was previously overlooked due to lack of functional expression in the cell lines usually used for studying TLR signaling. HMGB1 binding to TLR5 initiates the activation of NF-κB signaling pathway in a MyD88-dependent manner, resulting in pro-inflammatory cytokine production and pain enhancement in vivo. Biophysical and in vitro results highlight an essential role for the C-terminal tail region of HMGB1 in facilitating interactions with TLR5. These results suggest that HMGB1-modulated TLR5 signaling is responsible for pain hypersensitivity.” Study Link

I see HMGB1 come up in almost all modern diseases. This must be the most popular RAGEs.

COPD, Lung Cancer and RAGE

The proof that carb consumption also contributes to lung cancer is in the following report. The underlying cause is inflammation.

·        The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro.”

Abstract

INTRODUCTION:

Genome-Wide Association Studies have identified associations between lung function measures and Chronic Obstructive Pulmonary Disease (COPD) and chromosome region 6p21 containing the gene for the Advanced Glycation End Product Receptor (AGER, encoding RAGE). We aimed to (i) characterize RAGE expression in the lung, (ii) identify AGER transcripts, (iii) ascertain if SNP rs2070600 (Gly82Ser C/T) is associated with lung function and serum sRAGE levels and (iv) identify whether the Gly82Ser variant is functionally important in altering sRAGE levels in an airway epithelial cell model.

METHODS:

Immunohistochemistry was used to identify RAGE protein expression in 26 human tissues and qPCR was used to quantify AGER mRNA in lung cells. Gene expression array data was used to identify AGER expression during lung development in 38 fetal lung samples. RNA-Seq was used to identify AGER transcripts in lung cells. sRAGE levels were assessed in cells and patient serum by ELISA. BEAS2B-R1 cells were transfected to over express RAGE protein with either the Gly82 or Ser82 variant and sRAGE levels identified.

RESULTS:

Immunohistochemical assessment of 6 adult lung samples identified high RAGE expression in the alveoli of healthy adults and individuals with COPD. AGER/RAGE expression increased across developmental stages in human fetal lung at both the mRNA (38 samples) and protein levels (20 samples). Extensive AGER splicing was identified. The rs2070600T (Ser82) allele is associated with higher FEV1, FEV1/FVC and lower serum sRAGE levels in UK smokers. Using an airway epithelium model overexpressing the Gly82 or Ser82 variants we found that HMGB1 activation of the RAGE-Ser82 receptor results in lower sRAGE production.

CONCLUSIONS:

This study provides new information regarding the expression profile and potential role of RAGE in the human lung and shows a functional role of the Gly82Ser variant. These findings advance our understanding of the potential mechanisms underlying COPD particularly for carriers of this AGER polymorphism.  Study Link

I wonder if the ACS, American Cancer Society will take this information and realize what foods are responsible for this report showing how RAGEs have a role in COPD and ultimately lung cancer? Will it provoke a response from the ACS on the consumption of the foods responsible for this RAGE? Will they issue a warning or are they more concerned with an industry that depends on this disorder, the pharmaceutical industry, or maybe an industry that provokes this disorder, the grain industry?

You may ask though, shouldn’t smoking play a larger role in this equation? I submit that if the glycation never existed in the first place, the smoking wouldn’t play as large of a role as it does with the inflammation in the body. It takes the glycation to create the RAGE responsible for lung cancer, yet no one knows of glycation or its effects from the FDA, the USDA or the CDC. Who are they trying to protect? Why isn’t glycation considered a disease?

Skin Cancer and Glycation

In the following study the emergence of the HMGB1 RAGE in head and the skin cancer, neck squamous cell carcinoma;

·        “Clinical Value of High Mobility Group Box 1 and the Receptor for Advanced Glycation End-products in Head and Neck Cancer: A Systematic Review.”

Introduction High mobility group box 1 is a versatile protein involved in gene transcription, extracellular signaling, and response to inflammation. Extracellularly, high mobility group box 1 binds to several receptors, notably the receptor for advanced glycation end-products. Expression of high mobility group box 1 and the receptor for advanced glycation end-products has been described in many cancers. 

Objectives To systematically review the available literature using PubMed and Web of Science to evaluate the clinical value of high mobility group box 1 and the receptor for advanced glycation end-products in head and neck squamous cell carcinomas. 

Data synthesis A total of eleven studies were included in this review. High mobility group box 1 overexpression is associated with poor prognosis and many clinical and pathological characteristics of head and neck squamous cell carcinomas patients. Additionally, the receptor for advanced glycation end-products demonstrates potential value as a clinical indicator of tumor angiogenesis and advanced staging. In diagnosis, high mobility group box 1 demonstrates low sensitivity. 

Conclusion High mobility group box 1 and the receptor for advanced glycation end-products are associated with clinical and pathological characteristics of head and neck squamous cell carcinomas. Further investigation of the prognostic and diagnostic value of these molecules is warranted.” Study Link

Cataracts and Glycation

Although the study above was published in Oct 2016, this kind of evidence has been around for over 20 years. These reports started showing up in 1984;

We have examined the nonenzymatic glycation of human lens crystallin, an extremely long-lived protein, from 16 normal human ocular lenses 0.2-99 yr of age, and from 11 diabetic lenses 52-82-yr-old…the nonenzymatic glycation of nondiabetic lens crystallin may be regarded as a biological clock…The glucitol-lysine (Glc-Lys) content of soluble and insoluble crystallin was determined after reduction with H-borohydride followed by acid hydrolysis, boronic acid affinity chromatography, and high pressure cation exchange chromatography…Over an age range comparable to that of the control samples, the diabetic crystallin samples contained about twice as much Glc-Lys.

Cardiovascular Disease and RAGE

This study shows glycations implication in cardiovascular disease;

·        Therapeutic interventions for Advanced Glycation-End Products and its Receptor-Mediated Cardiovascular Disease.

“Advanced glycation end products (AGEs) are heterogeneous group of molecules formed from non-enzymatic reaction of reducing sugars with amino group of proteins, lipids, and nucleic acid. Interaction of AGEs with its cell-bound receptor (RAGE) results in generation of oxygen radicals, nuclear factor kappa-β, pro-inflammatory cytokines and cell adhesion molecules, and is involved in the pathophysiology of cardiovascular diseases (CVD). Circulating soluble forms of RAGE (sRAGE) and endo-secretory RAGE (esRAGE) compete with RAGE for ligand binding and function as a decoy. This paper describes the endogenous and exogenous (high dietary AGEs, cooking food under high dry heat, elevated pH, and long period) sources of AGEs. AGE-RAGE-mediated CVD includes atherosclerosis, coronary artery disease, carotid artery disease, hypertension, peripheral vascular diseases, heart failure, cardiomyopathy, and microangiopathy. The therapeutic intervention with reduction in AGEs and RAGE, and elevation in sRAGE has been reported for the treatment of AGE-RAGE-mediated CVD. Reduction in levels of AGEs can be achieved by reduction in consumption of food containing or creating low amount of AGEs, cooking food at low temperature, moist heat, and shorter duration. AGE formation can be reduced with drugs, vitamins and stoppage of cigarette smoking. Statins, telmisartan, and curcumin have been used for suppression of RAGE. Statins, ACE-inhibitors, Rosiglitazone and vitamin D have been used to increase levels of sRAGE. Finally exogenous administration of sRAGE can be helpful in amelioration of CVD. In conclusion, AGE-RAGE-mediated CVD could be attenuated with reduction in consumption of AGEs, suppression of RAGE and elevation of sRAGE.”

Dangers of Statins

Statins are the most dangerous in the above equation as they unbalance your cholesterol which puts everything in your body out of balance. It’s your cholesterol that regulates a good portion of your hormones. You should already know how much your hormones affect your emotions, energy, intelligence, aging, and basic proper functioning of your body, right down to digesting carbs (insulin). Granted insulin is made in the pancreas, although other more influential hormones are made in your fat which is what statins reduce. Side effects of statins include; Common statin-related side effects (headaches, stomach upset, abnormal liver function tests and muscle cramps) were similar to other statins. Side effects of statins include muscle pain, increased risk of diabetes mellitus, and abnormalities in liver enzyme tests. Additionally, they have rare but severe adverse effects, particularly muscle damage. As of 2010, a number of statins are on the market: atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin. Several combination preparations of a statin and another agent, such as ezetimibe/simvastatin, are also available. In 2005 sales were estimated at $18.7 billion in the United States.

Side effects ultimately lead to other drugs down the road. It’s inevitable. This is how the pharmaceutical corporations make as much money as they do. And you gladly give it to them, simply to keep up your addiction and later to fight your CVD or cancer. How much sense this make to you?

What concerns me more than anything else is the fact the atorvastatin in the best selling pharmaceutical in history, with sales of $12.4 billion in 2008. With all of the side effects listed above, how many patients taking these drugs will not ever have to use any more pharmaceuticals. This is the way they guarantee a return consumer. I know. (I was one of them. I won’t be any more due to my keto diet.)

The best-selling statin is atorvastatin, which in 2003 became the best-selling pharmaceutical in history. The manufacturer Pfizer reported sales of US$12.4 billion in 2008. Pfizer and Monsanto were under one roof at in 2003. That was the year Pfizer started their divesture of Monsanto. (Maybe it was the lawsuits that were starting to pile up, that they didn’t appreciate.) I wonder how many law suits Pfizer has against itself for its pharmaceutical statins. Below are the contraindications for atorvastatin (Lipitor);

Contraindications

The side effects of Lipitor are even longer and include diarrhea, dyspepsia, myalgia and nausea. Are you on statins? Did you read over your drug disclosure? Were you told that you could cure this without drugs? Were you ever told that this disorder started in your diet of carbs? The earliest report in the PMC I found was dated Jan, 1974 and simply stated that weight reduction was important to controlling hyperlipoproteinemia, a fancy word for high amounts of apolipoproteins in the body which indicate levels of cholesterol.

According to a study completed in 1995;

Population studies linking low cholesterol to noncoronary mortalities do not demonstrate cause-and-effect relations. In fact, based on current studies, the opposite is more likely to be the case. Drug intervention, however, should be used conservatively, particularly in young adults and the elderly. Drugs should be used only after diet and lifestyle interventions have failed. The evidence linking high blood cholesterol to coronary atherosclerosis and cholesterol lowering to its prevention is broad-based and definitive. Concerns about cholesterol lowering and spontaneously low cholesterols should be pursued but should not interfere with the implementation of current public policies to reduce the still heavy burden of atherosclerosis in Western society.

Another study from 1994 showed the rethinking of the low-fat hi-carb diet that has been pushed for over 40 years (probably at the insistence of Monsanto). Since they owned GD Searle at the time it makes me wonder, was their intent to hook us on more drugs? Even as recent Dec 31, 2016 the dept of research at Kaiser Permanente Southern California, Pasadena came to the conclusion; Statin use rather than cholesterol level was associated with lower mortality risk in patients with pancreatic cancer. Statins appear to improve survival through a lipid-independent mechanism. Apparently they’re rethinking their strategies. I have a strategy, don’t eat carbs. I go keto and let the fasting take care of the illnesses. If it can work for me it can work for you.

Our medical industry has had research for over 20 years on the benefits of cholesterol and the dangers of lowering it, yet because of our dependence on grains and sugar and Monsanto’s influence in the FDA and USDA, the recommendations from the USDA’s agency for food labeling to food safety to Myplate, the CCNP and at least 3 other agencies in the USDA alone, the CDC, the ADA, the ACS still recommend that you keep whole grains in your diet, regardless of the studies completed that show their danger. Why? Monsanto is in the crop seed industry owning over 15 crop seed companies, all wanting to sell GMO seed ready to handle Roundup herbicide to farmers contracted by Monsanto waiting to plant their next crop. They’ll spray their crops according to their contract with Monsanto. It then goes on your table.

This article appeared 22 years ago in PubMed in Aug, 1994. Even then low cholesterol was being questioned, yet in some corners, it’s still promoted today;

Although hypercholesterolemia is associated with increased liability to death from heart disease, it is as frequently associated with increased overall life expectancy as with decreased life expectancy. These findings are incompatible with labeling hypercholesterolemia an overall health hazard. Moreover, it is questionable if the cardiovascular liability associated with hypercholesterolemia is either causal or reversible. The complex relationships between diet, serum cholesterol, atherosclerosis and mortality and their interactions with genetic and environmental factors suggest that the effects of simple dietary prescriptions are unlikely to be predictable, let alone beneficial. These cautions are borne out by numerous studies which have shown that multifactorial primary intervention to lower cholesterol levels is as likely to increase death from cardiovascular causes as to decrease it. Importantly, the only significant overall effect of cholesterol-lowering intervention that has ever been shown is increased mortality.

With Monsanto’s influence in the FDA, the USDA, the EPA and who knows what else, who’s to protect our food supply? You have to protect yourself. Monsanto has proven they can’t self regulate their industry and keep us safe. The best way to start being safe is to not eat their food, which happens to include all grains. If you don’t buy them, that may send the message.

Direct Influence of Glycation in Cancer

More evidence of its influence in cancer is when this HMGB1 RAGE rears its ugly head again, influencing cancer;

·        Blockade of High Mobility Group Box 1 (HMGB1) augments anti-tumor T-cell response induced by peptide vaccination as a co-adjuvant.

“High Mobility Group Box 1 (HMGB1) is a member of the damage-associated molecular patterns (DAMPs), which cause inflammation and trigger innate immunity through Toll-like receptors (TLRs) 2/4 and the receptor for advanced glycation end products (RAGE). We examined the effect of glycyrrhizin, a selective inhibitor of HMGB1, on the induction of cytotoxic T-lymphocytes (CTLs) in mice. B6 mice, either OT-1 spleen cell-transferred or untransferred, were immunized with an s.c. injection of OVA257-264 peptide with topical imiquimod, and glycyrrhizin was mixed with the antigen peptide. Proliferation of OT-1 cells after immunization was enhanced by glycyrrhizin. The effect of glycyrrhizin was confirmed in other adjuvant systems, such as CpG oligonucleotide and monophosphoryl lipid A (MPL), but glycyrrhizin was not effective in Freund’s incomplete adjuvant system. The augmenting effects of glycyrrhizin were also observed in other synthetic HMGB1 inhibitors, i.e., gabexate mesilate, nafamostat, and sivelstat. Thus the effects are common to the HMGB1 inhibitors. Induction of CTLs detected by IFN-γ ELISPOT assay was similarly augmented by glycyrrhizin. In a therapeutic vaccine model, glycyrrhizin inhibited the growth of s.c. transplanted EG.7 tumors. Expression of inflammatory cytokines in the skin inoculation site was downregulated by glycyrrhizin. These results suggest that HMGB1 inhibitors might be useful as a co-adjuvant for peptide vaccination with an innate immunity receptor-related adjuvant. This article is protected by copyright. All rights reserved.” Study Link

Were you ever told that this could happen if you continued your diet of bread, corn, soy and other carbs? (Neither was I.)

This is evidence of glycation’s effect on the kidneys:

·        AGEs/sRAGE, a novel risk factor in the pathogenesis of end-stage renal disease.

“Interaction of advanced glycation end products (AGEs) with its cell-bound receptor (RAGE) results in cell dysfunction through activation of nuclear factor kappa-B, increase in expression and release of inflammatory cytokines, and generation of oxygen radicals. Circulating soluble receptors, soluble receptor (sRAGE), endogenous secretory receptor (esRAGE) and cleaved receptor (cRGAE) act as decoy for RAGE ligands and thus have cytoprotective effects. Low levels of sRAGE and esRAGE have been proposed as biomarkers for many diseases. However sRAGE and esRAGE levels are elevated in diabetes and chronic renal diseases and still tissue injury occurs. It is possible that increases in levels of AGEs are greater than increases in the levels of soluble receptors in these two diseases. Some new parameters have to be used which could be an universal biomarkers for cell dysfunction. It is hypothesized that increases in serum levels of AGEs are greater than the increases in the soluble receptors, and that the levels of AGEs is correlated with soluble receptors and that the ratios of AGEs/sRAGE, AGEs/esRAGE and AGEs/cRAGE are elevated in patients with end-stage renal disease (ESRD) and would serve as an universal risk marker for ESRD. The study subject comprised of 88 patients with ESRD and 20 healthy controls. AGEs, sRAGE and esRAGE were measured using commercially available enzyme linked immune assay kits. cRAGE was calculated by subtracting esRAGE from sRAGE. The data show that the serum levels of AGEs, sRAGE, cRAGE are elevated and that the elevation of AGEs was greater than those of soluble receptors. The ratios of AGEs/sRAGE, AGEs/esRAGE and AGEs/cRAGE were elevated and the elevation was similar in AGEs/sRAGE and AGEs/cRAGE but greater than AGEs/esRAGE. The sensitivity, specificity, accuracy, and positive and negative predictive value of AGEs/sRAGE and AGEs/cRAGE were 86.36 and 84.88 %, 86.36 and 80.95 %, 0.98 and 0.905, 96.2 and 94.8 %, and 61.29 and 56.67 % respectively. There was a positive correlation of sRAGE with esRAGE and cRAGE, and AGEs with esRAGE; and negative correlation between sRAGE and AGEs/sRAGE, esRAGE and AGES/esRAGE, and cRAGE and AGES/cRAGE. In conclusion, AGEs/sRAGE, AGEs/cRAGE and AGEs/esRAGE may serve as universal risk biomarkers for ESRD and that AGEs/sRAGE and AGEs/cRAGE are better risk biomarkers than AGEs/esRAGE.” Study Link

Breast Cancer and RAGE

This is the evidence that breast cancer is influenced by glycation;

·        Increased Expression of the Receptor for AdvancedGlycation End-Products (RAGE) Is Associated with Advanced Breast Cancer Stage.

“Abstract

BACKGROUND:

The receptor for advanced glycation end-products (RAGE) is a multiligand transmembrane receptor that is overexpressed in various pathological conditions including cancers. However, the expression pattern of RAGE in breast cancer tumors is still not completely clear.

METHODS:

In this study, we investigated the expression levels of RAGE in 25 fresh-frozen breast cancer samples and corresponding noncancerous tissue samples collected from breast cancer patients, by real-time polymerase chain reaction (PCR). Additionally, we performed immunohistochemistry on breast cancer specimens.

RESULTS:

The results indicate a high expression of the RAGE-encoding gene in the cancerous tissues. RAGE expression at the mRNA and protein levels was statistically significantly up-regulated in advanced-stage and triple-negative breast tumors and node-positive tissues compared with other tissues (p < 0.001). A significant association between RAGE expression and tumor size was observed (p = 0.029).

CONCLUSIONS:

Overexpression of RAGE in advanced-stage tumors may be a useful biomarker for diagnosis and the prediction of breast cancer progression.” Study Link

I’m only sorry that I could include studies and reports for all forms of cancer, but with they’re being so many of them, that’s a virtually impossible task.

Evidence of bone density decline from glycation;

·        AdvancedGlycationEnd Products, Diabetes, and Bone Strength.

“Diabetic patients have a higher fracture risk than expected by their bone mineral density (BMD). Poor bone quality is the most suitable and explainable cause for the elevated fracture risk in this population. Advanced glycation end products (AGEs), which are diverse compounds generated via a non-enzymatic reaction between reducing sugars and amine residues, physically affect the properties of the bone material, one of a component of bone quality, through their accumulation in the bone collagen fibers. On the other hand, these compounds biologically act as agonists for these receptors for AGEs (RAGE) and suppress bone metabolism. The concentrations of AGEs and endogenous secretory RAGE, which acts as a “decoy receptor” that inhibits the AGEs-RAGE signaling axis, are associated with fracture risk in a BMD-independent manner. AGEs are closely associated with the pathogenesis of this unique clinical manifestation through physical and biological mechanisms in patients with diabetes mellitus.” Study link

Evidence of Alzheimer’s disease from glycation;

Genetic association between RAGE polymorphisms and Alzheimer’s disease and Lewy body dementias in a Japanese cohort: a case-control study.

“Abstract

BACKGROUND/AIMS:

Interaction of receptor for advanced glycation end products (RAGE) with amyloid-β increases amplification of oxidative stress and plays pathological roles in Alzheimer’s disease (AD). Oxidative stress leads to α-synuclein aggregation and is also a major contributing factor in the pathogenesis of Lewy body dementias (LBDs). Therefore, we aimed to investigate whether RAGE gene polymorphisms were associated with AD and LBDs.

METHODS:

Four single nucleotide polymorphisms (SNPs)-rs1800624, rs1800625, rs184003, and rs2070600-of the gene were analyzed using a case-control study design comprising 288 AD patients, 76 LBDs patients, and 105 age-matched controls.

RESULTS:

Linkage disequilibrium (LD) examination showed strong LD from rs1800624 to rs2070600 on the gene (1.1 kb) in our cases in Japan. Rs184003 was associated with an increased risk of AD. Although there were no statistical associations for the other three SNPs, haplotypic analyses detected genetic associations between AD and the RAGE gene. Although relatively few cases were studied, results from the SNPs showed that they did not modify the risk of developing LBDs in the Japanese population.

CONCLUSION:

Our findings suggested that polymorphisms in the RAGE gene are involved in genetic susceptibility to AD. Copyright © 2016 John Wiley & Sons, Ltd.”  Study Link

With the above evidence showing its involvement in brain diseases, how does this information get hidden? Doesn’t anyone of authority examine these reports?  More evidence below of cancer causing agents from glycation leaving me to wonder; is anyone looking out for our benefit?

·        M2 macrophages do not fly into a “RAGE”.

“Tumor-associated macrophages (TAMs) are key elements in orchestrating host responses inside tumor stroma. This population may undergo a polarized activation process, thus rendering a heterogeneous spectrum of phenotypes, where the classically activated type 1 macrophages (M1) and the alternative activated type 2 macrophages (M2) represent two extreme phenotypes. In this commentary, based on very recent research findings, we intend to highlight how complex could be the crosstalk among all components of tumor stroma, where the coexistence of non-natural partners may even skew the canonical responses that we can expect.”  Study Link

This is where your addiction starts with this evidence of glycation causing agents in baby food. This is indicative of the glucose in the formula. Ask yourself why this is done, if glucose is capable of doing this much harm;

·        “Protein breakdown and release of β-casomorphins during in vitro gastro-intestinal digestion of sterilized model systems of liquid infant formula.”

“Protein modifications occurring during sterilization of infant formulas can affect protein digestibility and release of bioactive peptides. The effect of glycation and cross-linking on protein breakdown and release of β-casomorphins was evaluated during in vitro gastro-intestinal digestion (GID) of six sterilized model systems of infant formula. Protein degradation during in vitro GID was evaluated by SDS-PAGE and by measuring the nitrogen content of ultrafiltration (3kDa) permeates before and after in vitro GID of model IFs. Glycation strongly hindered protein breakdown, whereas cross-linking resulting from β-elimination reactions had a negligible effect. Only β-casomorphin 7 (β-CM7) was detected (0.187-0.858mgL(-1)) at the end of the intestinal digestion in all untreated IF model systems. The level of β-CM7 in the sterilized model systems prepared without addition of sugars ranged from 0.256 to 0.655mgL(-1). The release of this peptide during GID was hindered by protein glycation.” Study Link

This study explains that it’s the glycative results are what drives inflammation and  in type 1 diabetics, this was just released Oct15, 2016. Watch to see if you’ll hear anything about it. If you don’t, it’s probably because Big Pharma has something to say about it;

·        The Receptor for AdvancedGlycationEndproducts Drives T Cell Survival and Inflammation in Type 1 Diabetes Mellitus.

“The ways in which environmental factors participate in the progression of autoimmune diseases are not known. After initiation, it takes years before hyperglycemia develops in patients at risk for type 1 diabetes (T1D). The receptor for advanced glycation endproducts (RAGE) is a scavenger receptor of the Ig family that binds damage-associated molecular patterns and advanced glycated endproducts and can trigger cell activation. We previously found constitutive intracellular RAGE expression in lymphocytes from patients with T1D. In this article, we show that there is increased RAGE expression in T cells from at-risk euglycemic relatives who progress to T1D compared with healthy control subjects, and in the CD8+ T cells in the at-risk relatives who do versus those who do not progress to T1D. Detectable levels of the RAGE ligand high mobility group box 1 were present in serum from at-risk subjects and patients with T1D. Transcriptome analysis of RAGE+ versus RAGE T cells from patients with T1D showed differences in signaling pathways associated with increased cell activation and survival. Additional markers for effector memory cells and inflammatory function were elevated in the RAGE+ CD8+ cells of T1D patients and at-risk relatives of patients before disease onset. These studies suggest that expression of RAGE in T cells of subjects progressing to disease predates dysglycemia. These findings imply that RAGE expression enhances the inflammatory function of T cells, and its increased levels observed in T1D patients may account for the chronic autoimmune response when damage-associated molecular patterns are released after cell injury and killing.”

Study Link

Evidence of the role of AGEs in the process of neurodegenerative diseases;

·        “Impact of Non-Enzymatic Glycation in Neurodegenerative Diseases: Role of Natural Products in Prevention.”

“Non-enzymatic protein glycosylation is the addition of free carbonyls to the free amino groups of proteins, amino acids, lipoproteins and nucleic acids resulting in the formation of early glycation products. The early glycation products are also known as Maillard reaction which undergoes dehydration, cyclization and rearrangement to form advanced glycation end-products (AGEs). By and large the researchers in the past have also established that glycation and the AGEs are responsible for most type of metabolic disorders, including diabetes mellitus, cancer, neurological disorders and aging. The amassing of AGEs in the tissues of neurodegenerative diseases shows its involvement in diseases. Therefore, it is likely that inhibition of glycation reaction may extend the lifespan of an individual. The hunt for inhibitors of glycation, mainly using in vitro models, has identified natural compounds able to prevent glycation, especially polyphenols and other natural antioxidants. Extrapolation of results of in vitro studies on the in vivo situation is not straightforward due to differences in the conditions and mechanism of glycation, and bioavailability problems. Nevertheless, existing data allow postulating that enrichment of diet in natural anti-glycating agents may attenuate glycation and, in consequence may halt the aging and neurological problems.” Study Link

The following is evidence of glycations role in cardiovascular disease;

·        “Advanced Glycation End-Products Induce Apoptosis of Vascular Smooth Muscle Cells: A Mechanism for Vascular Calcification.”

“Vascular calcification, especially medial artery calcification, is associated with cardiovascular death in patients with diabetes mellitus and chronic kidney disease (CKD). To determine the underlying mechanism of vascular calcification, we have demonstrated in our previous report that advanced glycation end-products (AGEs) stimulated calcium deposition in vascular smooth muscle cells (VSMCs) through excessive oxidative stress and phenotypic transition into osteoblastic cells. Since AGEs can induce apoptosis, in this study we investigated its role on VSMC apoptosis, focusing mainly on the underlying mechanisms. A rat VSMC line (A7r5) was cultured, and treated with glycolaldehyde-derived AGE-bovine serum albumin (AGE3-BSA). Apoptotic cells were identified by Terminal deoxynucleotidyl transferased UTP nick end labeling (TUNEL) staining. To quantify apoptosis, an enzyme-linked immunosorbent assay (ELISA) for histone-complexed DNA fragments was employed. Real-time PCR was performed to determine the mRNA levels. Treatment of A7r5 cells with AGE3-BSA from 100 µg/mL concentration markedly increased apoptosis, which was suppressed by Nox inhibitors. AGE3-BSA significantly increased the mRNA expression of NAD (P)H oxidase components including Nox4 and p22(phox), and these findings were confirmed by protein levels using immunofluorescence. Dihydroethidisum assay showed that compared with cBSA, AGE3-BSA increased reactive oxygen species level in A7r5 cells. Furthermore, AGE3-induced apoptosis was significantly inhibited by siRNA-mediated knockdown of Nox4 or p22 (phox). Double knockdown of Nox4 and p22 (phox) showed a similar inhibitory effect on apoptosis as single gene silencing. Thus, our results demonstrated that NAD (P)H oxidase-derived oxidative stress are involved in AGEs-induced apoptosis of VSMCs. These findings might be important to understand the pathogenesis of vascular calcification in diabetes and CKD.”

Evidence of glycation in mental disorders like schizophrenia;

·        “The regulation of soluble receptor for AGEs contributes to carbonyl stress in schizophrenia.

“Our previous study showed that enhanced carbonyl stress is closely related to schizophrenia. The endogenous secretory receptor for advanced glycation end-products (esRAGE) is a splice variant of the AGER gene and is one of the soluble forms of RAGE. esRAGE is considered to be a key molecule for alleviating the burden of carbonyl stress by entrapping advanced glycation end-products (AGEs). In the current study, we conducted genetic association analyses focusing on AGER, in which we compared 212 schizophrenic patients to 214 control subjects. We also compared esRAGE levels among a subgroup of 104 patients and 89 controls and further carried out measurements of total circulating soluble RAGE (sRAGE) in 25 patients and 49 healthy subjects. Although the genetic association study yielded inconclusive results, multiple regression analysis indicated that a specific haplotype composed of rs17846798, rs2071288, and a 63 bp deletion, which were in perfect linkage disequilibrium (r2 = 1), and rs2070600 (Gly82Ser) were significantly associated with a marked decrease in serum esRAGE levels. Furthermore, compared to healthy subjects, schizophrenia showed significantly lower esRAGE (p = 0.007) and sRAGE (p = 0.03) levels, respectively. This is the first study to show that serum esRAGE levels are regulated by a newly identified specific haplotype in AGER and that a subpopulation of schizophrenic patients are more vulnerable to carbonyl stress. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.” Study Link

Evidence of glycation in renal disease and kidney cancer;

·        Growth arrest specific 2-like protein 1 expression is upregulated in podocytes through advanced  glycation end-products.

“BACKGROUND:

Growth arrest specific 2-like protein 1 (GAS2L1) protein is a member of the GAS2 family of proteins, known to regulate apoptosis and cellular cytoskeleton reorganization in different cells. Recently we identified that Gas2l1 gene expression in podocytes is influenced by advanced glycation end product-bovine serum albumin(AGE-BSA).

METHODS:

The study was performed employing cultured podocytes and diabetic (db/db) mice, a model of type 2 diabetes. Akbuminuria as well as urinary neutrophil gelatinase-associated lipocalin (NGAL) excretion as measured with specific ELISAs. Gene expression was analyzed via semiquantitative and real-time polymerase chain reaction. The protein levels were determined by western blotting and immunostaining.

RESULTS:

We found that the Gas2l1α isoform is expressed in podocytes. Treatment with AGE-BSA induced Gas2l1α and Gas2 mRNA levels compared with controls incubated with non-glycated control BSA (Co-BSA). Moreover, application of the recombinant soluble receptor of AGEs (sRAGE), a competitor of cellular RAGE, reversed the AGE-BSA effect. Interestingly, AGE-BSA also increased the protein levels of GAS2L1α in a RAGE-dependent manner, but did not affect the GAS2 expression. Periodic acid-Schiff staining and albuminuria as well as urinary NGAL excretion revealed that db/db mice progressively developed diabetic nephropathy with renal accumulation of Nε-carboxy-methyl-lysine (immunohistochemistry, western blots). Analyses of GAS2L1α and GAS2 proteins in diabetic mice revealed that both were significantly elevated relative to their non-diabetic littermates. In addition, GAS2L1α and GAS2 proteins positively correlated with the accumulation of AGEs in the blood plasma of diabetic mice and the administration of sRAGE in diabetic mice reduced the glomerular expression of both proteins.

CONCLUSIONS:

We show for the first time that the protein expression of GAS2L1α in vitro and in vivo is regulated by the AGE-RAGE axis. The suppression of AGE ligation with their RAGE in diabetic mice with progressive nephropathy reversed the GAS2L1α expression, thus suggesting a role of GAS2L1α in the development of diabetic disease, which needs to be further elucidated. © The Author 2016. Published by Oxford University Press on behalf of ERA-EDTA.” Study Link

Methylglyoxal is what makes up pyruvic acid which is a foundation for energy expenditure. It comes from glycogen which comes from glucose and can be made into lipids to be used for cholesterol or glucose to be used by your brain when it the ketones aren’t enough to power all lobes in the brain. This the link from glucose to disease through its conversion to AGEs, advanced glycation endproducts as explained by this study published Sep, 2016;

“Glucose and fructose metabolism originates the highly reactive by product methylglyoxal (MG), which is a strong precursor of advanced glycation end products (AGE). The MG has been implicated in classical diabetic complications such as retinopathy, nephropathy, and neuropathy, but has also been recently associated with cardiovascular diseases and central nervous system disorders such as cerebrovascular diseases and dementia. Recent studies even suggested its involvement in insulin resistance and beta-cell dysfunction, contributing to the early development of type 2 diabetes and creating a vicious circle between glycation and hyperglycemia. Despite several drugs and natural compounds have been identified in the last years in order to scavenge MG and inhibit AGE formation, we are still far from having an effective strategy to prevent MG-induced mechanisms. This review summarizes the endogenous and exogenous sources of MG, also addressing the current controversy about the importance of exogenous MG sources. The mechanisms by which MG changes cell behavior and its involvement in type 2 diabetes development and complications and the pathophysiological implication are also summarized. Particular emphasis will be given to pathophysiological relevance of studies using higher MG doses, which may have produced biased results. Finally, we also overview the current knowledge about detoxification strategies, including modulation of endogenous enzymatic systems and exogenous compounds able to inhibit MG effects on biological systems.”  Study Link

Evidence of glycations influence in pancreatic cancer;

·        AdvancedGlycationEnd Products Impair Glucose-Stimulated Insulin Secretion of a Pancreatic β-Cell Line INS-1-3 by Disturbance of Microtubule Cytoskeleton via p38/MAPK Activation.

Advanced glycation end products (AGEs) are believed to be involved in diverse complications of diabetes mellitus. Overexposure to AGEs of pancreatic β-cells leads to decreased insulin secretion and cell apoptosis. Here, to understand the cytotoxicity of AGEs to pancreatic β-cells, we used INS-1-3 cells as a β-cell model to address this question, which was a subclone of INS-1 cells and exhibited high level of insulin expression and high sensitivity to glucose stimulation. Exposed to large dose of AGEs, even though more insulin was synthesized, its secretion was significantly reduced from INS-1-3 cells. Further, AGEs treatment led to a time-dependent increase of depolymerized microtubules, which was accompanied by an increase of activated p38/MAPK in INS-1-3 cells. Pharmacological inhibition of p38/MAPK by SB202190 reversed microtubule depolymerization to a stabilized polymerization status but could not rescue the reduction of insulin release caused by AGEs. Taken together, these results suggest a novel role of AGEs-induced impairment of insulin secretion, which is partially due to a disturbance of microtubule dynamics that resulted from an activation of the p38/MAPK pathway.” Study Link

In my estimation this is the worst manifestation of bread in the diet. Amyloid plaque is at the root of most modern diseases, ranging from cancer to heart disease to arthritis to Alzheimer’s disease and Parkinson’s disease;

·        Glycationinduced generation of amyloid fibril structures by glucose metabolites.

“The non-enzymatic reaction (glycation) of reducing sugars with proteins has received increased interest in dietary and therapeutic research lately. In the present work, the impact of glycation on structural alterations of camel serum albumin (CSA) by different glucose metabolites was studied. Glycation of CSA was evaluated by specific fluorescence of advanced glycation end-products (AGEs) and determination of available amino groups. Further, conformational changes in CSA during glycation were also studied using 8-analino 1-nephthlene sulfonic acid (ANS) binding assay, circular dichroism (CD) and thermal analysis. Intrinsic fluorescence measurement of CSA showed a 22 nm red shift after methylglyoxal treatment, suggesting glycation induced denaturation of CSA. Rayleigh scattering analysis showed glycation induced turbidity and aggregation in CSA. Furthermore, ANS binding to native and glycated-CSA reflected perturbation in the environment of hydrophobic residues. However, CD spectra did not reveal any significant modifications in the secondary structure of the glycated-CSA. Thioflavin T (ThT) fluorescence of CSA increased after glycation, illustrated cross β-structure and amyloid formation. Transmission electron microscopy (TEM) analysis further reaffirms the formation of aggregate and amyloid. In summary, glucose metabolites induced conformational changes in CSA and produced aggregate and amyloid structures.”

This is more evidence of glycation’s involvement in Alzheimer’s disease. This report was submitted on Aug 24 2016, have you heard anything about this yet? Who doesn’t want you to know? Who has interests in selling your medication for memory loss? How would you learn this information if you didn’t see it here? Do you know where to look for it? Do you even know to look for it? Am I fishing or can this be a conspiracy?

·        HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer’s disease.

“BACKGROUND:

The blood-brain barrier (BBB) dysfunction represents an early feature of Alzheimer’s disease (AD) that precedes the hallmarks of amyloid beta (amyloid β) plaque deposition and neuronal neurofibrillary tangle (NFT) formation. A damaged BBB correlates directly with neuroinflammation involving microglial activation and reactive astrogliosis, which is associated with increased expression and/or release of high-mobility group box protein 1 (HMGB1) and thrombin. However, the link between the presence of these molecules, BBB damage, and progression to neurodegeneration in AD is still elusive. Therefore, we aimed to profile and validate non-invasive clinical biomarkers of BBB dysfunction and neuroinflammation to assess the progression to neurodegeneration in mild cognitive impairment (MCI) and AD patients.

METHODS:

We determined the serum levels of various proinflammatory damage-associated molecules in aged control subjects and patients with MCI or AD using validated ELISA kits. We then assessed the specific and direct effects of such molecules on BBB integrity in vitro using human primary brain microvascular endothelial cells or a cell line.

RESULTS:

We observed a significant increase in serum HMGB1 and soluble receptor for advanced glycation end products (sRAGE) that correlated well with amyloid beta levels in AD patients (vs. control subjects). Interestingly, serum HMGB1 levels were significantly elevated in MCI patients compared to controls or AD patients. In addition, as a marker of BBB damage, soluble thrombomodulin (sTM) antigen, and activity were significantly (and distinctly) increased in MCI and AD patients. Direct in vitro BBB integrity assessment further revealed a significant and concentration-dependent increase in paracellular permeability to dextrans by HMGB1 or α-thrombin, possibly through disruption of zona occludins-1 bands. Pre-treatment with anti-HMGB1 monoclonal antibody blocked HMGB1 effects and leaving BBB integrity intact.

CONCLUSIONS:

Our current studies indicate that thrombin and HMGB1 are causal proximate proinflammatory mediators of BBB dysfunction, while sTM levels may indicate BBB endothelial damage; HMGB1 and sRAGE might serve as clinical biomarkers for progression and/or therapeutic efficacy along the AD spectrum.” Study Link

More evidence of the damaging effects of glycation was submitted July15, 2016. Have you heard anything about this report yet?

“The incidence of food allergy has increased dramatically in the last few decades in westernized developed countries. We propose that the Western lifestyle and diet promote innate danger signals and immune responses through production of “alarmins. Alarmins are endogenous molecules secreted from cells undergoing nonprogrammed cell death that signal tissue and cell damage. High molecular group S (HMGB1) is a major alarmin that binds to the receptor for advanced glycation end-products (RAGE). Advanced glycation end-products (AGEs) are also present in foods. We propose the “false alarm” hypothesis, in which AGEs that are present in or formed from the food in our diet are predisposing to food allergy. The Western diet is high in AGEs, which are derived from cooked meat, oils, and cheese. AGEs are also formed in the presence of a high concentration of sugars. We propose that a diet high in AGEs and AGE-forming sugars results in misinterpretation of a threat from dietary allergens, promoting the development of food allergy. AGEs and other alarmins inadvertently prime innate signaling through multiple mechanisms, resulting in the development of allergic phenotypes. Current hypotheses and models of food allergy do not adequately explain the dramatic increase in food allergy in Western countries. Dietary AGEs and AGE-forming sugars might be the missing link, a hypothesis supported by a number of convincing epidemiologic and experimental observations, as discussed in this article.” Study Link

The author  of this report isn’t fully aware of what causes glycation. He still thinks that protein and fat are important as they are what gets glycated, but they’re not the important factor in this equation. It’s the glucose that’s important, as it’s the glucose that does the glycating. If one were to remove the glucose, they’d remove the glycation.

Again no alert about this evidence of the influence of glycation in dementia submitted in Aug 2016 from the Oxford Journal of Gerontology;

·        Inflammatory Biomarkers Predict Domain-Specific Cognitive Decline in Older Adults.

“BACKGROUND:

Vascular risk factors, including inflammation, may contribute to dementia development. We investigated the associations between peripheral inflammatory biomarkers and cognitive decline in five domains (memory, construction, language, psychomotor speed, and executive function).

METHODS:

Community-dwelling older adults from the Ginkgo Evaluation of Memory Study (n = 1,159, aged 75 or older) free of dementia at baseline were included and followed for up to 7 years. Ten biomarkers were measured at baseline representing different sources of inflammation: vascular inflammation (pentraxin 3 and serum amyloid P), endothelial function (endothelin-1), metabolic function (adiponectin, resistin, and plasminogen activating inhibitor-1), oxidative stress (receptor for advanced glycation end products), and general inflammation (interleukin-6, interleukin-2, and interleukin-10). A combined z-score was created from these biomarkers to represent total inflammation across these sources. We utilized generalized estimating equations that included an interaction term between z-scores and time to assess effect of inflammation on cognitive decline, adjusting for demographics (such as age, race/ethnicity, and sex), cardiovascular risk factors, and apolipoprotein E ε4 carrier status. A Bonferroni-adjusted significance level of .01 was used. We explored associations between individual biomarkers and cognitive decline without adjustment for multiplicity.

RESULTS:

The combined inflammation z-score was significantly associated with memory and psychomotor speed (p < .01). Pentraxin 3, serum amyloid P, endothelin-1, and interleukin-2 were associated with change in at least one cognitive domain (p < .05).

CONCLUSION:

Our results suggest that total inflammation is associated with memory and psychomotor speed. In particular, systemic inflammation, vascular inflammation, and altered endothelial function may play roles in domain-specific cognitive decline of nondemented individuals. © The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.”        Study Link

Are you beginning to wonder why we’ve never been informed of these dangers? Evidence below of glycation in lung cancer was submitted on Aug9, 2016. I’ve not heard anything about this. Doesn’t the ACS care? They’re still recommending carbs in the diet, so they must not;

“Effects of carboxymethyllysine (CML) and pentosidine, two advanced glycation end-products (AGEs), upon invasion and migration in A549 and Calu-6 cells, two non-small cell lung cancer (NSCLC) cell lines were examined. CML or pentosidine at 1, 2, 4, 8 or 16 μmol/L were added into cells. Proliferation, invasion and migration were measured. CML or pentosidine at 4-16 μmol/L promoted invasion and migration in both cell lines, and increased the production of reactive oxygen species, tumor necrosis factor-α, interleukin-6 and transforming growth factor-β1. CML or pentosidine at 2-16 μmol/L up-regulated the protein expression of AGE receptor, p47(phox), intercellular adhesion molecule-1 and fibronectin in test NSCLC cells. Matrix metalloproteinase-2 protein expression in A549 and Calu-6 cells was increased by CML or pentosidine at 4-16 μmol/L. These two AGEs at 2-16 μmol/L enhanced nuclear factor κ-B (NF-κ B) p65 protein expression and p38 phosphorylation in A549 cells. However, CML or pentosidine at 4-16 μmol/L up-regulated NF-κB p65 and p-p38 protein expression in Calu-6 cells. These findings suggest that CML and pentosidine, by promoting the invasion, migration and production of associated factors, benefit NSCLC metastasis.” Study Link

This is the evidence of your back problems being caused by glycation. This study shows how the inflammatory responses to glycation causing vertebral disk degeneration;

“Inflammation and cytokines have been recognized to correlate with intervertebral disc (IVD) degeneration (IDD), via mediating the development of clinical signs and symptoms. However, the regulation mechanism remains unclear. We aimed at investigating the regulatory role of interleukin (IL)β and high mobility group box 1 (HMGB1) in the inflammatory response in human IVD cells, and then explored the signaling pathways mediating such regulatory effect. Firstly, the promotion to inflammatory cytokines in IVD cells was examined with ELISA method. And then western blot and real time quantitative PCR were performed to analyze the expression of toll-like receptors (TLRs), receptors for advanced glycation endproducts (RAGE) and NF-κB signaling markers in the IL-1β- or (and) HMGB1-treated IVD cells. Results demonstrated that either IL-1β or HMGB1 promoted the release of the inflammatory cytokines such as prostaglandin E2 (PGE2), TNF-α, IL-6 and IL-8 in human IVD cells. And the expression of matrix metalloproteinases (MMPs) such as MMP-1, -3 and -9 was also additively up-regulated by IL-1β and HMGB1. We also found such additive promotion to the expression of TLR-2, TLR-4 and RAGE, and the NF-κB signaling in intervertebral disc cells. In summary, our study demonstrated that IL-1β and HMGB1 additively promotes the release of inflammatory cytokines and the expression of MMPs in human IVD cells. The TLRs and RAGE and the NF-κB signaling were also additively promoted by IL-1β and HMGB1. Our study implied that the additive promotion by IL-1β and HMGB1 to inflammatory cytokines and MMPs might aggravate the progression of IDD.”  Study Link

Even unborn babies are not immune to the effects if glycation;

·        Accumulation of AdvancedGlycationEnd Products Involved in Inflammation and Contributing to Severe Preeclampsia, in Maternal Blood, Umbilical Blood and Placental Tissues.

 

Ovarian cancer is a consequence of glycation;

S100B is one of the members of the S100 protein family and is involved in the progression of a variety of cancers. Ovarian cancer is driven by cancer stem-like cells (CSLCs) that are involved in tumor genesis, metastasis, chemo-resistance and relapse. We then hypothesized that S100B might exert pro-tumor effects by regulating ovarian CSLCs stemness, a key characteristic of CSLCs. First, we observed the high expression of S100B in ovarian cancer specimens when compared to that in normal ovary. The S100B upregulation associated with more advanced tumor stages, poorer differentiation and poorer survival. In addition, elevated S100B expression correlated with increased expression of stem cell markers including CD133, Nanog and Oct4. Then, we found that S100B was preferentially expressed in CD133+ ovarian CSLCs derived from both ovarian cancer cell lines and primary tumors of patients. More importantly, we revealed that S100B knockdown suppressed the in vitro self-renewal and in vivo tumorigenicity of ovarian CSLCs and decreased their expression of stem cell markers. S100B ectopic expression endowed non-CSLCs with stemness, which has been demonstrated with both in vitro and in vivo experiments. Mechanically, we demonstrated that the underlying mechanism of S100B-mediated effects on CSLCs stemness was not dependent on its binding with a receptor for advanced glycation end products (RAGE), but might be through intracellular regulation, through the inhibition of p53 expression and phosphorylation. In conclusion, our results elucidate the importance of S100B in maintenance of ovarian CSLCs stemness, which might provide a promising therapeutic target for ovarian cancer. Stem Cells 2016.”  Study Link

This study looks at the AGEs responsible for inflammatory bowel disease and Rheumatoid arthritis;

Neutrophils and monocytes belong to the first line of immune defence cells and are recruited to sites of inflammation during infection or sterile injury. Both cells contain huge amounts of the heterodimeric protein S100A8/A9 in their cytoplasm. S100A8/A9 belongs to the Ca2+ binding S100 protein family and has recently gained a lot of interest as a critical alarmin modulating the inflammatory response after its release (extracellular S100A8/A9) from neutrophils and monocytes. Extracellular S100A8/A9 interacts with the pattern recognition receptors Toll-like receptor 4 (TLR4) and Receptor for Advanced Glycation Endproducts (RAGE) promoting cell activation and recruitment. Besides its biological function, S100A8/A9 (also known as myeloid related protein 8/14, MRP8/14) was identified as interesting biomarker to monitor disease activity in chronic inflammatory disorders including inflammatory bowel disease and rheumatoid arthritis. Furthermore, S100A8/A9 has been tested successfully in pre-clinical imaging studies to localize sites of infection or sterile injury. Finally, recent evidence using small molecule inhibitors for S100A8/A9 also suggests that blocking S100A8/A9 activity exerts beneficial effects on disease activity in animal models of autoimmune diseases including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel disease. This review will provide a comprehensive and detailed overview into the structure and biological function of S100A8/A9 and also will give an outlook in terms of diagnostic and therapeutic applications targeting S100A8/A9.        Study Link

HMGB1 is a label that’s been assigned to a type of AGE or RAGE. It’s importance lies in its ability to create pain in your body. This is one of over 4976 warnings and notices of what glycation does to the body that available for your perusal on the effects of glycation on PubMed;

Neuropathic pain (NPP) is intolerable, persistent, and specific type of long-term pain. It is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients. Despite recent progress and growing interest in understanding the pathogenesis of the disease, NPP still presents a major diagnostic and therapeutic challenge. High mobility group box 1 (HMGB1) mediates inflammatory and immune reactions in nervous system and emerging evidence reveals that HMGB1 plays an essential role in neuroinflammation through receptors such as Toll-like receptors (TLR), receptor for advanced glycation end products (RAGE), C-X-X motif chemokines receptor 4 (CXCR4), and N-methyl-D-aspartate (NMDA) receptor. In this review, we present evidence from studies that address the role of HMGB1 in NPP. First, we review studies aimed at determining the role of HMGB1 in NPP and discuss the possible mechanisms underlying HMGB1-mediated NPP progression where receptors for HMGB1 are involved. Then we review studies that address HMGB1 as a potential therapeutic target for NPP.             Study Link

The following study was completed in July 2010, explaining the health benefits of calorie restriction. This is what was being researched over 120 years ago, as ketonuria was noticed in the urine of fasting patients, giving them ketonemia. This is a condition that best serves healing in the body for multiple reasons and has been shown to heal many diseases, simply from fasting. Since 500BC fasting has been used to cure many diseases with astonishing success. This is what’s known as ketosis today and is what your body goes through as a healing, fat burning type of metabolism. It uses your own fat to provide everything from hormones to glucose, through gluconeogenesis, the perfect glucose for the body as it made from your fat, making it a clean glucose source;

The societal impact of obesity, diabetes, and other metabolic disorders continues to rise despite increasing evidence of their negative long-term consequences on health span, longevity, and aging. Unfortunately, dietary management and exercise frequently fail as remedies, underscoring the need for the development of alternative interventions to successfully treat metabolic disorders and enhance life span and health span. Using calorie restriction (CR)—which is well known to improve both health and longevity in controlled studies—as their benchmark, gerontologists are coming closer to identifying dietary and pharmacological therapies that may be applicable to aging humans. This review covers some of the more promising interventions targeted to affect pathways implicated in the aging process as well as variations on classical CR that may be better suited to human adaptation.

Another report submitted Nov, 08 to the Official Journal of the International League Against Epilepsy, basically said the same thing while they were looking for the best way to approach putting the body into ketosis;

The ketogenic diet (KD) is a 90% fat diet that is an effective treatment for intractable epilepsy. Rapid initiation of the KD requires hospital admission because of the complexity of the protocol and frequent mild and moderate adverse events. The purpose of the study was to compare the efficacy of a gradual KD initiation with the standard KD initiation preceded by a 24- to 48-h fast.

Perhaps the most damning report against aging was issued in January of 1984, yet nothing was mentioned about this report; it was one of the first indications of what glycation does to the body and with a major cause of glycation being glucose or sugar, I have to wonder why the FDA didn’t say anything about it then. Why weren’t we, at least, informed about this study? Industry concerns?

·       Collagen aging in vitro by nonenzymatic glycosylation and browning.

Aging and diabetes mellitus are associated with cross-linking and nonenzymatic glycosylation of collagen. Incubation of tendon fibers with reducing sugars results in increased breaking time in urea similar to that seen in aging, and in nonenzymatic glycosylation and browning. Effect of a sugar is proportional to the amount of sugar available in the open chain form. The increase in breaking time correlates with the appearance of chromophores characteristic of crosslinked browning products. Collagen altered by nonenzymatic browning may play a role in some age-like major complications of diabetes.   Study Link

This evidence of glycation’s role in atherosclerosis was in this study submitted in May 1988. Was this publicized? Did you hear about this? Did the FDA know?

Adhesion of bovine endothelial cells on fibronectin and collagen before and after nonenzymatic glycation in vitro has been studied. Nonenzymatic glycation of these proteins reduced their ability to bind endothelial cells. Furthermore, nonenzymatically glycated fibronectin failed to bind to normal and nonenzymatically glycated gelatin and to fibrin. So gelatin and fibrin Sepharoses can be used to separate highly glycated fibronectins from fibronectins with a low degree of nonenzymatic glucose substitution. Sodium dodecylsulfate polyacrylamide gel electrophoresis did not demonstrate a covalent cross-link between nonenzymatically glycated fibronectins. These results present further evidences for the role of nonenzymatic glycation of proteins in the development of vascular complications in long-term diabetes and of atherosclerosis.              Study Link

This shows the damage done by glycation on the blood. I posted this study because I wanted to note what the first sentence states, that this damage, at the time of publication, had been known for 20 years. The date on this study is marked as July 29, 1988. That means that his damage was discovered in 1968, 48 years ago.

The association between elevated levels of glycated haemoglobins and diabetes mellitus has been known for twenty years [92]. Since then the determination of glycated haemoglobins has become a valuable tool for the objective assessment of long-term glycaemia in diabetic patients. The marked clinical interest in reliable measurements of glycated haemoglobins has stimulated the development and perfection of the necessary methodology. Limitations of the techniques have led to investigation of the underlying causes. Some of them led to the recognition of processes that were not known to occur in vivo before, such as glycation at sites other than the amino terminus of the beta-chains, modification of haemoglobin by reactants other than glucose or the existence of labile haemoglobin adducts. With ideal methodology these features would have gone unnoticed. Furthermore, the determination of glycated haemoglobin in large populations of diabetic patients has lead to the discovery of new, clinically silent mutant haemoglobins. Today, the routine determination of glycated haemoglobins in diabetic patients probably represents the broadest screening for mutant haemoglobins. The experience with glycated haemoglobins shows that overcoming difficulties in their determination, and progress in biomedical research, are closely intertwined.

This study shows how proteins exposed to glucose undergoes oxidative stress, the basis of aging;

Studies have shown that glycation in vitro is complicated by the ability of glucose to oxidise, in the presence of trace amounts of transition metal, generating protein-reactive ketoaldehydes, hydrogen peroxide and diverse free radicals. Protein exposed to glucose undergoes fragmentational and conformational alterations, and these, as well as thiol oxidation, appear to be caused by hydroxyl radicals. Glycofluorophore formation is dependent upon ketoaldehyde formation. It is suggested that glucose autoxidation contributes to oxidative stress in pathophysiology associated with diabetes and ageing via this newly described process of “autoxidative glycosylation”.

The following report from Oct 30 1981 shows the effects of glycation on cholesterol, LDL particles particularly and how it leads to atherosclerosis ;

Atherosclerosis occurs at an accelerated rate in patients with diabetes mellitus. Since some proteins undergo nonenzymatic glycosylation in diabetic patients and because certain chemical modifications of low density lipoproteins produced alterations in their interactions with certain cultured cells, a fact that may be relevant to atherogenesis, we investigated the effect of in vitro glycosylation on cell-related properties of low density lipoproteins. Glycosylation was carried out by incubating LDL (1-10 mg LDL-protein/ml) with glucose (0-100 mM) in 0.5 M phosphate buffer, pH 8.0, at 37 degrees C. The amount of glucose incorporated into LDL after 1-2 wk of incubation was estimated to be in the range of 1-10 mol/mol LDL-protein. Amino acid analysis of glycosylated LDL showed that glucose was covalently bound to lysine residues. In studies with cultured human fibroblasts, glycosylated LDL was internalized and degraded significantly less than control LDL, in proportion to the estimated degree of glycosylation (12% of control for the most extensively glycosylated LDL). Glycosylation of LDL also impaired significantly its ability to stimulate cholesteryl ester synthesis by cultured fibroblasts. Glycosylated LDL did not stimulate cholesteryl ester synthesis in rat peritoneal macrophages. If glycosylation of LDL occurs in diabetic patients, some pathophysiologic consequences related to the increased incidence of atherosclerosis in these patients may result.

Study Link

In 1981 this was discovered, yet it’s been 35 years since then and yet few people are aware of this. My question is, why?  Maybe I should ask the sugar industry.

The following study shows the how the adhesive qualities of glucose creates fibrinogen, which becomes a target for glycation;

·        Polymerisation and crosslinking of fibrin monomers in diabetes mellitus

Polymerisation and crosslinking of fibrin monomers was studied in 35 healthy volunteers and in 42 poorly controlled diabetic patients. Polymerisation did not show any difference between control subjects (n = 10) and diabetic patients (n = 11) (p greater than 0.1), although fibrinogen was 35% more glycated in the diabetic patients (p less than 0.001). Alpha chain crosslinking in the diabetic patients, however, was impaired as is shown from an increase in intermediate alpha polymers with a concomitant decrease in alpha monomer disappearance. A significant positive correlation was found between the degree of glycation of fibrinogen and the defective alpha chain polymerisation (r = 0.86, p less than 0.005). These results were consistent with the results of thrombin and reptilase experiments. The reaction rate with reptilase did not show any difference between the two groups (p greater than 0.1), whereas the reaction rate with thrombin was significantly slower in the diabetic group compared to the control subjects (p less than 0.001). Purified fibrin clots obtained from the diabetic patients were more susceptible to plasmin than clots obtained from control subjects. It is concluded that in poorly controlled diabetic patients polymerisation of fibrin monomers is normal, but crosslinking of the alpha chains is impaired, leading to a higher susceptibility of the clots to plasmin degradation.

From Wikipedia on Fibrinogen;

Fibrinogen (factor I) is a glycoprotein in vertebrates that helps in the formation of blood clots. It consists of a linear array of three nodules held together by a very thin thread which is estimated to have a diameter between 8 and 15 Angstrom (Å). The two end nodules are alike but the center one is slightly smaller. Measurements of shadow lengths indicate that nodule diameters are in the range 50 to 70 Å. The length of the dried molecule is 475 ± 25 Å.[2]

·        Effect of  of low-density lipoprotein on the immunological determination glycation of apolipoprotein B.

Non-enzymatic glycation of low-density lipoprotein (LDL) may contribute to the premature atherogenesis of patients with diabetes mellitus. To assess whether  glycation of apolipoprotein B, the predominant protein of LDL, interferes with the ability to immunologically quantify this protein, we prepared and purified glycated LDL by incubating normal plasma samples with high concentrations of glucose. Although both the plasma and the LDL specimens incubated with glucose contained significantly more glycated protein than control specimens, the quantitative interaction of an apolipoprotein B-specific antibody with glycated vs nonglycated LDL was not significantly different. We conclude that apolipoprotein B can be accurately quantified immunologically despite the presence of clinically excessive degrees of LDL glycation.

Study Link

I included the following study from November 1989 because of its explanation of how glycation is responsible for inflammation;

·        Changes in concanavalin A-reactive proteins in inflammatory disorders.

Quantitative changes of concanavalin A (Con A)-reactive proteins in serum samples obtained from rats with induced inflammation and from patients with inflammatory and autoimmune diseases were examined by use of lectin blots. Treatment of rats with a single dose of fermented yeast to induce inflammation caused an extensive increase in Con A-reactivity. These changes were time dependent and were similar in both sexes of the animals. When we examined serum samples obtained from patients with various inflammatory disorders for their Con A-reactive proteins as compared with normal donors, we noted that the Con A-reactivity increased in patients with rheumatoid arthritis and systemic lupus erythematosus. Among all the glycoproteins examined by lectin blots with use of Con A, a set of five proteins was selected for detailed analysis by densitometric scanning. These included alpha 2-macroglobulin, P-150, P-95, P-40, and P-35, of Mr 180,000, 150,000, 95,000, 40,000, and 35,000, respectively, by sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions. Densitometric scanning analysis of the lectin blots revealed that the Con A-reactivity of these proteins increased during inflammation. Because alpha 2-macroglobulin is not an acute-phase protein in humans, an increase in Con A staining of this protein suggested that altered glycation is associated with autoimmune diseases. Thus, study of changes in Con A-reactive proteins in human sera may facilitate our understanding of the etiology and pathophysiology of autoimmune diseases.                  Study Link

·        Clinical Value of High Mobility Group Box 1 and the Receptor for Advanced Glycation End-products in Head and Neck Cancer: A Systematic Review.

Abstract Introduction High mobility group box 1 is a versatile protein involved in gene transcription, extracellular signaling, and response to inflammation. Extracellularly, high mobility group box 1 binds to several receptors, notably the receptor for advanced glycation end-products. Expression of high mobility group box 1 and the receptor for advanced glycation end-products has been described in many cancers. Objectives To systematically review the available literature using PubMed and Web of Science to evaluate the clinical value of high mobility group box 1 and the receptor for advanced glycation end-products in head and neck squamous cell carcinomas. Data synthesis A total of eleven studies were included in this review. High mobility group box 1 overexpression is associated with poor prognosis and many clinical and pathological characteristics of head and neck squamous cell carcinomas patients. Additionally, the receptor for advanced glycation end-products demonstrates potential value as a clinical indicator of tumor angiogenesis and advanced staging. In diagnosis, high mobility group box 1 demonstrates low sensitivity. Conclusion High mobility group box 1 and the receptor for advanced glycation end-products are associated with clinical and pathological characteristics of head and neck squamous cell carcinomas. Further investigation of the prognostic and diagnostic value of these molecules is warranted.”

“Diabetes is frequently associated with cardiovascular diseases (coronary heart disease, cerebrovascular disease, peripheral vascular disease), and several risk factors have been proposed. Recent studies have strengthened the importance of chronic hyperglycemia because this modifies a variety of circulating substances including lipoproteins, and the glycosylated ones can be involved in the process of accelerating atherosclerosis. In this review, previous studies indicating the significance of glycosylated lipoproteins in the progression of atherosclerosis were overviewed. We also discussed AGE (advanced glycation end products) which may play an important role of atherogenesis in diabetes.”The most recent study, submitted in October 2016 reveals some of the known damage that glycation is responsible for;

·        Relationship between plasma glycation with membrane modification, oxidative stress and expression of glucose trasporter-1 in type 2 diabetes patients with vascular complications.

BACKGROUND OF STUDY:

Enhanced protein glycation in diabetes causes irreversible cellular damage through membrane modifications. Erythrocytes are persistently exposed to plasma glycated proteins; however, little are known about its consequences on membrane. Aim of this study was to examine the relationship between plasma protein glycation with erythrocyte membrane modifications in type 2 diabetes patients with and without vascular complications.

METHOD:

We recruited 60 healthy controls, 85 type 2 diabetic mellitus (DM) and 75 type 2 diabetic patients with complications (DMC). Levels of plasma glycation adduct with antioxidants (fructosamine, protein carbonyl, β-amyloids, thiol groups, total antioxidant status), erythrocyte membrane modifications (protein carbonyls, β-amyloids, free amino groups, erythrocyte fragility), antioxidant profile (GSH, catalase, lipid peroxidation) and Glut-1 expression were quantified.

RESULT:

Compared with controls, DM and DMC patients had significantly higher level of glycation adducts, erythrocyte fragility, lipid peroxidation and Glut-1 expression whereas declined levels of plasma and cellular antioxidants. Correlation studies revealed positive association of membrane modifications with erythrocyte sedimentation rate, fragility, peroxidation whereas negative association with free amino groups, glutathione and catalase.

CONCLUSION:

Our data suggest that plasma glycation is associated with oxidative stress, Glut-1 expression and erythrocyte fragility in DM patients. This may further contribute to progression of vascular complications.

More evidence of the role glucose plays in brain degradation;

Protein glycation is an age-dependent posttranslational modification associated with several neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. By modifying amino-groups, glycation  interferes with folding of proteins, increasing their aggregation potential. Here, we studied the effect of pharmacological and genetic manipulation of glycation on huntingtin (HTT), the causative protein in Huntington’s disease (HD). We observed that glycation increased the aggregation of mutant HTT exon 1 fragments associated with HD (HTT72Q and HTT103Q) in yeast and mammalian cell models. We found that glycation impairs HTT clearance thereby promoting its intracellular accumulation and aggregation. Interestingly, under these conditions autophagy increased and the levels of mutant HTT released to the culture medium decreased. Furthermore, increased  glycation enhanced HTT toxicity in human cells and neurodegeneration in fruit flies, impairing eclosion and decreasing life span. Overall, our study provides evidence that glycation modulates HTT exon-1 aggregation and toxicity, and suggests it may constitute a novel target for therapeutic intervention in HD.

Evidence of the glycative effects in Cataracts was know in the fall of 1974, yet nothing was said that I can remember, but then I was just getting out of Jr College then;

J Clin Invest. 1984 Nov;74(5):1742-9.

Garlick RLMazer JSChylack LT JrTung WHBunn HF.

We have examined the nonenzymatic glycation of human lens crystallin, an extremely long-lived protein, from 16 normal human ocular lenses 0.2-99 yr of age, and from 11 diabetic lenses 52-82-yr-old. The glucitol-lysine (Glc-Lys) content of soluble and insoluble crystallin was determined after reduction with H-borohydride followed by acid hydrolysis, boronic acid affinity chromatography, and high pressure cation exchange chromatography. Normal lens crystallin, soluble and insoluble, had 0.028 +/- 0.011 nanomoles Glc-Lys per nanomole crystallin monomer. Soluble and insoluble crystallins had equivalent levels of glycation. The content of Glc-Lys in normal lens crystallin increased with age in a linear fashion. Thus, the nonenzymatic glycation of nondiabetic lens crystallin may be regarded as a biological clock. The diabetic lens crystallin samples (n = 11) had a higher content of Glc-Lys (0.070 +/- 0.034 nmol/nmol monomer). Over an age range comparable to that of the control samples, the diabetic crystallin samples contained about twice as much Glc-Lys. The Glc-Lys content of the diabetic lens crystallin samples did not increase with lens age.

This study look at the effects of glycation on your eyes and the cataracts is responsible for. Yes glycation and a glucose diet will buy you cataracts. My mother had two of them. A good who loved to eat her bread had cataracts in both of her eyes as well. What’s interesting, this person was always complaining of headaches and stomach aches, both manifestations of an ECC diet. Again, here is more evidence of the glycative and addictive effects of a grain diet.

The following report provides evidence of glycation’s role in Leukemia.

Extracellular HMGB1 promotes differentiation of nurse-like cells in chronic lymphocytic leukemia.

“Chronic lymphocytic leukemia (CLL) is a disease of an accumulation of mature B cells that are highly dependent on the microenvironment for maintenance and expansion. However, little is known regarding the mechanisms whereby CLL cells create their favorable microenvironment for survival. High-mobility group protein B-1 (HMGB1) is a highly conserved nuclear protein that can be actively secreted by innate immune cells and passively released by injured or dying cells. We found significantly increased HMGB1 levels in the plasma of CLL patients compared with healthy controls, and HMGB1 concentration is associated with absolute lymphocyte count. We therefore sought to determine potential roles of HMGB1 in modulating the CLL microenvironment. CLL cells passively released HMGB1, and the timing and concentrations of HMGB1 in the medium were associated with differentiation of nurse-like cells (NLCs). Higher CD68 expression in CLL lymph nodes, one of the markers for NLCs, was associated with shorter overall survival of CLL patients. HMGB1-mediated NLC differentiation involved internalization of both receptor for advanced  glycation end products (RAGE) and Toll-like receptor-9 (TLR9). Differentiation of NLCs can be prevented by blocking the HMGB1-RAGE-TLR9 pathway. In conclusion, this study demonstrates for the first time that CLL cells might modulate their microenvironment by releasing HMGB1.”         Free PMC Article

J Clin Invest. 1984 Nov;74(5):1742-9.

After searching these last few disorders I got a yen to search any disorder & glycation, and glycation turned up in everything except halitosis. The following report shows its involvement in stomach ulcers. I originally searched just ulcers and got back 30 studies showing involvement. The first few studies in the list were reports on foot ulcers, so I search stomach ulcers and found 3 studies, the following report was the first;

High-mobility group box 1 (HMGB1) was initially discovered as a nuclear protein that interacts with DNA as a chromatin-associated non-histone protein to stabilize nucleosomes and to regulate the transcription of many genes in the nucleus. Once leaked or actively secreted into the extracellular environment, HMGB1 activates inflammatory pathways by stimulating multiple receptors, including Toll-like receptor (TLR) 2, TLR4, and receptor for advanced glycation end products (RAGE), leading to tissue injury. Although HMGB1’s ability to induce inflammation has been well documented, no studies have examined the role of HMGB1 in wound healing in the gastrointestinal field. The aim of this study was to evaluate the role of HMGB1 and its receptors in the healing of gastric ulcers. We also investigated which receptor among TLR2, TLR4, or RAGE mediates HMGB1’s effects on ulcer healing. Gastric ulcers were induced by serosal application of acetic acid in mice, and gastric tissues were processed for further evaluation. The induction of ulcer increased the immunohistochemical staining of cytoplasmic HMGB1 and elevated serum HMGB1 levels. Ulcer size, myeloperoxidase (MPO) activity, and the expression of tumor necrosis factor α (TNFα) mRNA peaked on day 4. Intraperitoneal administration of HMGB1 delayed ulcer healing and elevated MPO activity and TNFα expression. In contrast, administration of anti-HMGB1 antibody promoted ulcer healing and reduced MPO activity and TNFα expression. TLR4 and RAGE deficiency enhanced ulcer healing and reduced the level of TNFα, whereas ulcer healing in TLR2 knockout (KO) mice was similar to that in wild-type mice. In TLR4 KO and RAGE KO mice, exogenous HMGB1 did not affect ulcer healing and TNFα expression. Thus, we showed that HMGB1 is a complicating factor in the gastric ulcer healing process, which acts through TLR4 and RAGE to induce excessive inflammatory responses.                                  Free PMC Article

 

  • Nonenzymatic glycation of human lens crystallin. Effect of aging and diabetes mellitus.

Garlick RLMazer JSChylack LT JrTung WHBunn HF.

This study looked at the effects of glycation on your eyes and the cataracts it’s responsible for. Yes glycation and a glucose diet will buy you cataracts. My mother had two of them. A good friend who loved to eat her bread had cataracts in both of her eyes as well. What’s interesting, this person was always complaining of headaches and stomach aches. Both of those manifestations are from an ECC diet. Again, here is more evidence of the glycative and addictive effects of a grain diet. In all, there were 3,629 studies on the effects of glucose glycating proteins, hemoglobin, and cholesterol dating back to March, 1984. Incidentally, that was one month after I was released from the hospital after spending a month in a coma and suffering two strokes while comatose. I could have never come back this far without Dr Perlmutter’s help. Again, I have to thank you, Dr Perlmutter.

I found this study done Sep 5, 2014 on autism and environmental factors. The only factor that mirrored the rise in autism was the use of glyphosate herbicides. Note the similarity.  For me, this is enough to shut down the use of Roundup and all generic versions. Will the USDA recommend this? Knowing who runs the USDA, I seriously doubt it. Although it has little to do with glycation, it expresses the danger of the herbicide that’s used on virtually all grains today.

An external file that holds a picture, illustration, etc. Object name is 12940_2014_781_Fig6_HTML.jpg
Temporal trend in autism compared to temporal trend in U.S. application of glyphosate to genetically-modified corn and soy crops, as estimated from US Department of Agriculture data (see Additional file 1 ).
 The author of this last report tries to dance around the issue of the glyphosate herbicide’s relationship to autism, but the evidence is clear.

They’ve had some of this evidence for over 30 years, why hasn’t the public been told about glycation or the AGEs they create? It’s those AGEs that are at the root of all modern diseases. If this was uncovered starting 30+ years ago, why have we just found out about it from the bestselling books from two doctors? Is someone trying to hide something? My guess is yes. This is Monsanto’s path to power and freedom. They’ve politically engineered their freedom to wreak whatever havoc they can on your health by masturbating your taste buds with their glucose laden products, to grant them power by buying into their pharmaceutical cycle in the very near future. By near, I mean, it only takes a couple days before you’re indebted. (That means addicted.) If you want true power and freedom, you can have it in two weeks to two months. That’s how long it takes to break the addiction.

Each and every one of these 11,000+ studies have been vetted and examined by the NIH and PubMed for whom I thank.

You have two choices;

  1. Continue to masturbate your taste buds and collect these diseases and disorders in return.
  2. Cut out as much as possible the starchy carbohydrates, (grains) and live free from dependence.

You need to realize that the comfort in comfort food, brings massive discomfort in the future, starting immediately, with a process called glycation. This is the real poisoning of America and we can correct it. It lies within our power, each and every one of us can correct this. I offer a cure, not a therapy or treatment, My cure simply involves removal of all glycating substances from the diet to eliminate this problem of glycation so that it never affects the body The glycating substances = carbs, sugar, glucose, fructose.

The above reports on the effects of glycation appeared in many cases, over 30 years ago in PubMed. I’ve only showed you 47 reports out of 11,750 studies to date detailing the damaging effects of Excessive Carbohydrate Consumption, the primary cause of glycation, why doesn’t the FDA or the USDA say anything about that? The 42nd   study, submitted in November, 1989 shows how it causes inflammation, and with inflammation a factor in so many diseases, it truly is a wonder that the FDA and USDA never even issued anything so simple as a warning. The FDA’s involvement in this issue is mostly explained by their influence from the one industry, where they get most of their execs from, Monsanto.

From every form of cancer to Alzheimer’s disease to heart disease and cardiovascular disease to arthritis to hypertension to high cholesterol these food sources (sugar and grains) are responsible for each and every one of these disorders. These studies are proof of exactly what sugar does to the body. To cure the glycation factor in these diseases, the best way is to eliminate it as much as possible. To do that you must eliminate its source and to eliminate the source, you have to eliminate the grains and sugar. Thank you Dr Davis and Dr Perlmutter for bringing this to my attention.

In all, there were 3,629 studies in the FDA’s database on the effects of glucose glycating proteins, hemoglobin, and cholesterol dating back to march, 1984. Incidentally, that was one month after i was released from the hospital after spending a month in a coma and suffering two strokes while comatose. I could have never come back this far without Dr Perlmutter’s help. Again, i have to thank you, Dr Perlmutter. The above, reports on the effects of glycation, appeared, in many cases over 30 years ago in PubMed. With 11,667 studies to date detailing the damaging effects of Excessive Carbohydrate Consumption, the primary cause of glycation, why doesn’t the FDA say anything? The last study, submitted in November, 1989 shows how it causes inflammation and with inflammation a factor in so many diseases, it truly is a wonder that the FDA never even issued anything as simple as a warning. The FDA’s involvement in this issue is largely explained by the influence they receive from the one industry where they get a good portion of their execs from, Monsanto.

With having the evidence for over 30 years, why hasn’t the public been told about glycation or the AGEs they create? It’s those AGEs that are at the root of all modern diseases. If this was uncovered 30+ years ago, why have we just found out about it from the bestselling books from two doctors? They weren’t published in 2010 and 2012 and they had to dig this information our of the archives. Is someone trying to hide something? In who’s best interest would it be to hide this information? The grain industry? My guess is yes.

From every for of cancer (with the possible exception of brain cancer, which I suspect is influenced by glycation simply because of the inflammation factor) to Alzheimer’s disease to heart disease and cardiovascular disease to arthritis to hypertension to high cholesterol these food sources (sugar and grains) are responsible for each and every one of these disorders. These studies are proof of exactly what sugar does to the body. To cure the glycation factor in these diseases, the best way is to eliminate it as much as possible. To do that you must eliminate its source and to eliminate the source, you have to eliminate the grains and sugar. Thank you Dr Davis and Dr Perlmutter for bringing this to my attention. It would have been nice if someone could have done it 20 or 30 years ago. For that, I thank the FDA, the USDA and Monsanto. Don’t allow them to be in your driver’s seat. As long as you remain on your carbohydrate diet, they’re in the driver’s seat for your health. Give up the carbs and put yourself back in the driver’s seat. You are the only one who can change yourself. Enable yourself to do so.

 

 

 

Documentaries worth watching;

  1. Food, Inc
  2. Food Matters
  3. Food Beware (French)
  4. Genetically Modified Foods
  5. David vs Monsanto
  6. Of the Land
  7. Hungry for Change
  8. That Sugar Film
  9. Fathead
  10. Love Paleo
  11. Heal Yourself
  12. Fresh
  13. Who Wants to Live Forever
  14. Overfed and Undernourished
  15. My Big Fat Body
  16. Facing the Fat
  17. Fat
  18. Just Eat It; A Food Waste Story