Tag Archives: GD Searle Pharmaceuticals

The Glucose Ruse to Feed You Disease, Compliments of the Grain and Pharmaceutical Industries

The Glucose Ruse to Feed You Disease

This is a matter of your health being engineered without your knowledge or consent. The engineering, in this case, is not good. Actually, it’s creating pain where none should exist. Our food supply industry may be the most important industry concerned when it comes to our health. As everyone knows, ‘you are what you eat’, so it’s vital that what you eat won’t make you sick. Unfortunately, for those who still masturbate their taste buds with their addiction to sugar, this couldn’t be further from the truth. Our food supply has been hijacked by the same industry that treats you for the illness their food supplies. Granted the healthcare industry is vital to our health, but I submit that it wouldn’t be as important as it is today if we paid more attention to what we eat. Because I now watch what I eat, I can change the “we” to “you”, meaning “you” have to watch what you eat. (All that means is that you still have an addiction to break, I don’t, I broke mine three years ago.) Because of this addiction, you’ve doomed yourself unwittingly to a lifetime of medications. That is unless you’re one of the .05% who shows no ill effects from glycation. I have yet to meet one of them. If you eat at a restaurant or buy groceries at a grocery store, you’re subject to this addiction. It’s in their food everywhere you look. You actually look for it because you love to eat it. You love their advertising. What’s not to love, it’s full of attractive people selling you what appears to provide health, but in all reality provides nothing but the opposite, as it’s responsible for most all pain, most all disease, all brain damage, all atherosclerosis, all diseases affiliated with inflammation, and this is just for starters.

Monsanto has politically engineered their dominance of your food supply and subsequent health by forcing as many farmers as they can to use Monsanto’s seed companies’ GMO seed to grow their crops. Monsanto has many seed companies. Their control over the seed industry is mirrored by their control over the pharmaceutical industry because they can use the seed companies to influence the profits of their drug companies. , owns 15 crop seed companies all selling GMO seed for their contracted farmers to grow. Five of these companies sell seed for wheat crops. That’s the seed that grows the wheat that’s ground into flour for your bread and crackers. Their contracted farmers have to grow Monsanto’s GMO seed at risk of facing legal action if caught growing anything else. This is how Monsanto controls what goes on your table to eat. This is also how Monsanto forces you into purchasing the Celebrex, made by GD Searle Pharmaceuticals. Searle has been part of Monsanto since 1985. The Celebrex is what your doctor prescribes for your arthritis that’s caused by the glycation set up from the grain diet you’ve been on all your life. After you get arthritis that you will inevitably get from eating their GMO grains, you’ll be begging your doctor for that prescription for the Celebrex. Then you’ll get to deal with the side effects of the Celebrex that it inevitably has and presents to the body. That’s the damage to your body from the drug side of their industry.  The damage from the crop seed side includes crops that are not only GMO seed, they are laden with Roundup, the glyphosate herbicide that works by inhibiting enzymes from doing what they supposed to do by instructing cells how to operate. Even though Monsanto claims that these enzyme inhibitors affect only targeted enzymes, the rise in cancer alone, that the nation has seen since the mid to late 80’s, has told a completely different story. The rise in these disorders is directly caused by an increase in the glycation that occurs in the blood by the high glucose laden grains this company forces their farmers to grow. That means that the food going on your table is engineered to make you need the medications that the pharmaceutical side of Monsanto’s companies sells.

 According to Wikipedia; “In December 1997 Monsanto merged with Pharmacia and Upjohn.[14] The agricultural division became a wholly owned subsidiary of the “new” Pharmacia; Monsanto’s medical research division, which included products such as Celebrex.[61]

GD Searle and Pharmacia are the other side of Monsanto’s multinational chemical companies,  that includes now,  Pfizer and Upjohn, as well. GD Searle was purchased by Monsanto in 1985 two years after Monsanto started dabbling in GMO crops.  In 1993 GD Searle file for a patent for Celebrex, its widely used arthritis drug. I’ll bet you didn’t know that it is Monsanto’s seed companies that force their contracted farmers to grow GMO seed designed to make you need their Celebrex. Is this what you thought you were buying when you bought those corn chips last time? Was this what you thought you were buying when you purchased those pretzels? Whether it was or not, that’s what you got. You also got all the rest of the damage that glycation does to the body, which includes cataracts, atherosclerosis, cancer and dementia as well. You’re also subjecting yourself to the hunger cycle, probably the worst manifestation of a carb diet. The more carbs you eat, the hungrier your get. That’s a cycle that can’t be broken if you don’t stop the fuel that feeds it. Stopping the fuel is the only way to stop the glycation. That means that it’s the only way to stop the inflammation, which means it’s the only way to stop the illness and disorder that glycation is responsible for.

This study done on glycative effects and Alzheimer’s disease was completed in 2005. Glycation of cholesterol into amyloid plaque was researched in this study. It showed that the plaque was responsible for Alzheimer’s disease. Where were the warnings then? It’s now 15 years later and millions of people have died from Alzheimer’s disease. The question I ask is why? Why weren’t we notified of this revelation 14 years ago? It’s been in the archives of PubMed since then. Why the delay? How many more must die before this news of the glycative effects of glucose, is released to the media to inform the public of this devastating news?

5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Aβ peptide-induced inflammatory mediators in astroglia

J Biol Chem. 1985 Sep 5;260(19):10629-36.

Glycation of amino groups in protein. Studies on the specificity of modification of RNase by glucose.

Watkins NGThorpe SRBaynes JW.

This study done on the effects of glucose on glycation was done in September 1985. Have you seen or heard of any part of this report prior to today? I haven’t. I had to search for it. The question I have is why wasn’t the public notified of this revelation? Were the research results suppressed so as to hide the truth from the public? I have to wonder.

About this same time, according to Wikipedia; In 1985, Monsanto acquired G. D. Searle & Company, a life sciences company focusing on pharmaceuticals, agriculture and animal health. In 1993, its Searle division filed a patent application for Celebrex,[42][43] which in 1998 became the first selective COX‑2 inhibitor to be approved by the U.S. Food and Drug Administration (FDA).[44] Celebrex became a blockbuster drug and was often mentioned as a key reason for Pfizer‘s acquisition of Monsanto’s pharmaceutical business in 2002.[45]

What wasn’t disclosed publicly was the benefit that the stockholders retained when the merger was finalized. Stockholders of Pharmacia retained 23% of their control in the new Pfizer. You wouldn’t think that would have an influence in what they do to grow their customer base to sell more drugs, would you? Regardless of what you think, it does, and they do care. Monsanto sends this industry most of their customers just from the damage their food does to those who eat it. This industry has grown to accommodate those customers, mostly with their diabetes industry and ever expanding interests in dementia. Inflammation,  cancer and atherosclerosis, just for starters.

Was it coincidence? I have to wonder. Since then Monsanto has made moves to control all of the grain industry in America, by contracting farmers to grow no other seed than their own GMO seed. This forces the farmers who do this, to spray massive amounts of herbicide on those crops. The herbicide they spray is Monsanto’s Roundup, a glyphosate herbicide that works by inhibiting the actions of enzymes. Enzymes are important proteins in the body as they’re cell signaling proteins that instruct cells how to operate. This is important because it’s that instruction that the cells need to not become glycation. Otherwise, without that enzyme, you create inflammation. Inflammation is the foundation of all modern diseases. This is why grains are slowly killing those who eat them, cutting their lives short, to the tune of 2,684 deaths every day, that can be attributed to these killing field grains. These signaling cells are cells like hormones and cytokines that affect your body’s functions. If these aren’t working because of any enzyme inhibitor floating around in your blood, it’s going to lead to glycation and disease. This is the scary part of this story, if you eat bread, crackers, corn chips or anything flour is used in (whether it’s wheat flour or corn flour), your eating this herbicide along with your bread and cornpone.

Did you have any idea that this was being done to you without your consent or knowledge? I didn’t until I did this research. Did you have time to do your research? Why not? If you couldn’t, wouldn’t you think that we need some regulation in the field? The FDA and the USDA are supposed to provide that. With Monsanto’s control of each of those agencies, how much honest regulation do you think could take place? The regulation that does take place, takes place only for the benefit of Monsanto and Pfizer, not the consumer. We end up the lab rats in  this experiment. In my opinion, this is a failed experiment and should be shut down as soon as possible.

This study was complete in September 1985, about the same time Monsanto acquired G.D. Searle Pharmaceuticals. 8 years later they filed for a patent for Celebrex, their arthritis pain killer drug. Celebrex is a Cox 2 NSAID with the following side effects and concerns, according to Searle, and I’m listing all of them;

Contraindications

NSAIDs may be used with caution by people with the following conditions:[6]

Irritable bowel syndrome[6]

  • Persons who are over age 50, and who have a family history of GI (gastrointestinal) problems[6]
  • Persons who have had past GI problems from NSAID use[6]

NSAIDs should usually be avoided by people with the following conditions:[6]

Adverse effects

The widespread use of NSAIDs has meant that the adverse effects of these drugs have become increasingly common. Use of NSAIDs increases risk of having a range of gastrointestinal(GI) problems.[16] When NSAIDs are used for pain management after surgery they cause increased risk of kidney problems.[17]

An estimated 10–20% of NSAID patients experience dyspepsia. In the 1990s high doses of prescription NSAIDs were associated with serious upper gastrointestinal adverse events, including bleeding.[18] Over the past decade, deaths associated with gastric bleeding have declined.

NSAIDs, like all drugs, may interact with other medications. For example, concurrent use of NSAIDs and quinolones may increase the risk of quinolones’ adverse central nervous system effects, including seizure.[19][20]

There is argument over the benefits and risks of NSAIDs for treating chronic musculoskeletal pain. Each drug has a benefit-risk profile [21] and balancing the risk of no treatment with the competing potential risks of various therapies is the clinician’s responsibility.

Combinational risk

If a COX-2 inhibitor is taken, a traditional NSAID (prescription or over-the-counter) should not be taken at the same time.[22][not in citation given] In addition, people on daily aspirin therapy (e.g., for reducing cardiovascular risk) must be careful if they also use other NSAIDs, as these may inhibit the cardio protective effects of aspirin.

Rofecoxib (Vioxx) was shown to produce significantly fewer gastrointestinal adverse drug reactions (ADRs) compared with naproxen.[23] This study, the VIGOR trial, raised the issue of the cardiovascular safety of the coxibs. A statistically significant increase in the incidence of myocardial infarctions was observed in patients on rofecoxib. Further data, from the APPROVe trial, showed a statistically significant relative risk of cardiovascular events of 1.97 versus placebo[24]—which caused a worldwide withdrawal of rofecoxib in October 2004.

Use of methotrexate together with NSAIDS in rheumatoid arthritis is safe, if adequate monitoring is done.[25]

Cardiovascular

NSAIDs aside from aspirin, both newer selective COX-2 inhibitors and traditional anti-inflammatories, increase the risk of myocardial infarction and stroke.[26][27] They are not recommended in those who have had a previous heart attack as they increase the risk of death and/or recurrent MI.[28]Evidence indicates that naproxen may be the least harmful out of these.[27][29]

NSAIDs aside from (low-dose) aspirin are associated with a doubled risk of heart failure in people without a history of cardiac disease.[29] In people with such a history, use of NSAIDs (aside from low-dose aspirin) was associated with a more than 10-fold increase in heart failure.[30] If this link is proven causal, researchers estimate that NSAIDs would be responsible for up to 20 percent of hospital admissions for congestive heart failure. In people with heart failure, NSAIDs increase mortality risk (hazard ratio) by approximately 1.2–1.3 for naproxen and ibuprofen, 1.7 for rofecoxib and celecoxib, and 2.1 for diclofenac.[31]

On 9 July 2015, the FDA toughened warnings of increased heart attack and stroke risk associated with nonsteroidal anti-inflammatory drugs (NSAID). Aspirin is an NSAID but is not affected by the new warnings.[32]

Possible erectile dysfunction risk

A 2005 Finnish study linked long term (over 3 months) use of NSAIDs with an increased risk of erectile dysfunction.[33] This study was correlational only, and depended solely on self-reports (questionnaires).

A 2011 publication [34] in the Journal of Urology received widespread publicity.[35] According to this study, men who used NSAIDs regularly were at significantly increased risk of erectile dysfunction. A link between NSAID use and erectile dysfunction still existed after controlling for several conditions. However, the study was observational and not controlled, with low original participation rate, potential participation bias, and other uncontrolled factors. The authors warned against drawing any conclusion regarding cause.[36]

Gastrointestinal

The main adverse drug reactions (ADRs) associated with NSAID use relate to direct and indirect irritation of the gastrointestinal (GI) tract. NSAIDs cause a dual assault on the GI tract: the acidic molecules directly irritate the gastric mucosa, and inhibition of COX-1 and COX-2 reduces the levels of protective prostaglandins. Inhibition of prostaglandin synthesis in the GI tract causes increased gastric acid secretion, diminished bicarbonate secretion, diminished mucus secretion and diminished trophic[clarification needed] effects on epithelial mucosa.

Common gastrointestinal ADRs include:[5]

Clinical NSAID ulcers are related to the systemic effects of NSAID administration. Such damage occurs irrespective of the route of administration of the NSAID (e.g., oral, rectal, or parenteral) and can occur even in patients with achlorhydria.[38]

Ulceration risk increases with therapy duration, and with higher doses. To minimise GI ADRs, it is prudent to use the lowest effective dose for the shortest period of time—a practice that studies show is often not followed. Recent studies show that over 50% of patients who take NSAIDs have sustained some mucosal damage to their small intestine.[39]

There are also some differences in the propensity of individual agents to cause gastrointestinal ADRs. Indomethacinketoprofen and piroxicam appear to have the highest prevalence of gastric ADRs, while ibuprofen (lower doses) and diclofenac appear to have lower rates.[5]

Certain NSAIDs, such as aspirin, have been marketed in enteric-coated formulations that manufacturers claim reduce the incidence of gastrointestinal ADRs. Similarly, some believe that rectal formulations may reduce gastrointestinal ADRs. However, consistent with the systemic mechanism of such ADRs, and in clinical practice, these formulations have not demonstrated a reduced risk of GI ulceration.[5]

Commonly, gastric (but not necessarily intestinal) adverse effects can be reduced through suppressing acid production, by concomitant use of a proton pump inhibitor, e.g., omeprazoleesomeprazole; or the prostaglandin analogue misoprostol. Misoprostol is itself associated with a high incidence of gastrointestinal ADRs (diarrhea). While these techniques may be effective, they are expensive for maintenance therapy.

Inflammatory bowel disease

NSAIDs should be used with caution in individuals with inflammatory bowel disease (e.g., Crohn’s disease or ulcerative colitis) due to their tendency to cause gastric bleeding and form ulceration in the gastric lining. Pain relievers such as paracetamol (also known as acetaminophen) or drugs containing codeine (which slows down bowel activity) are safer medications for pain relief in IBD.[citation needed]

Renal

NSAIDs are also associated with a fairly high incidence of renal adverse drug reactions (ADRs). The mechanism of these renal ADRs is due to changes in renal haemodynamics (kidney blood flow), ordinarily mediated by prostaglandins, which are affected by NSAIDs. Prostaglandins normally cause vasodilation of the afferent arterioles of the glomeruli. This helps maintain normal glomerular perfusion and glomerular filtration rate (GFR), an indicator of renal function. This is particularly important in renal failure where the kidney is trying to maintain renal perfusion pressure by elevated angiotensin II levels. At these elevated levels, angiotensin II also constricts the afferent arteriole into the glomerulus in addition to the efferent arteriole it normally constricts. Prostaglandins serve to dilate the afferent arteriole; by blocking this prostaglandin-mediated effect, particularly in renal failure, NSAIDs cause unopposed constriction of the afferent arteriole and decreased RPF (renal perfusion pressure).

Common ADRs associated with altered renal function include:[5]

Salt (Sodium) and fluid retention

Hypertension(high blood pressure)

These agents may also cause renal impairment, especially in combination with other nephrotoxic agents. Renal failure is especially a risk if the patient is also concomitantly taking an ACE inhibitor (which removes angiotensin II’s vasoconstriction of the efferent arteriole) and a diuretic (which drops plasma volume, and thereby RPF)—the so-called “triple whammy” effect.[40]

In rarer instances NSAIDs may also cause more severe renal conditions:[5]

Interstitial nephritis

Nephrotic syndrome

Acute renal failure

Acute tubular necrosis

Renal papillary necrosis

NSAIDs in combination with excessive use of phenacetinand/or paracetamol (acetaminophen) may lead to analgesic nephropathy.[41]

Photosensitivity

Photosensitivity is a commonly overlooked adverse effect of many of the NSAIDs.[42] The 2-arylpropionic acids are the most likely to produce photosensitivity reactions, but other NSAIDs have also been implicated including piroxicamdiclofenac and benzydamine.

Benoxaprofen, since withdrawn due to its hepatotoxicity, was the most photoactive NSAID observed. The mechanism of photosensitivity, responsible for the high photoactivity of the 2-arylpropionic acids, is the ready decarboxylation of the carboxylic acid moiety. The specific absorbance characteristics of the different chromophoric 2-aryl substituents, affects the decarboxylation mechanism. While ibuprofen has weak absorption, it has been reported as a weak photosensitising agent.[citation needed]

During pregnancy

NSAIDs are not recommended during pregnancy, particularly during the third trimester. While NSAIDs as a class are not direct teratogens, they may cause premature closure of the fetal ductus arteriosus and renal ADRs in the fetus. Additionally, they are linked with premature birth[43] and miscarriage.[44][45] Aspirin, however, is used together with heparin in pregnant women with antiphospholipid antibodies.[46] Additionally, Indomethacin is used in pregnancy to treat polyhydramnios by reducing fetal urine production via inhibiting fetal renal blood flow.

In contrast, paracetamol (acetaminophen) is regarded as being safe and well-tolerated during pregnancy, but Leffers et al. released a study in 2010 indicating that there may be associated male infertility in the unborn.[47][48] Doses should be taken as prescribed, due to risk of hepatotoxicity with overdoses.[49]

In France, the country’s health agency contraindicates the use of NSAIDs, including aspirin, after the sixth month of pregnancy.[50]

Allergy/allergy-like hypersensitivity reactions

A variety of allergic or allergic-like NSAID hypersensitivity reactions follow the ingestion of NSAIDs. These hypersensitivity reactions differ from the other adverse reactions listed here which are toxicity reactions, i.e. unwanted reactions that result from the pharmacological action of a drug, are dose-related, and can occur in any treated individual; hypersensitivity reactions are idiosyncratic reactions to a drug.[51] Some NSAID hypersensitivity reactions are truly allergic in origin: 1) repetitive IgE-mediated urticarial skin eruptions, angioedema, and anaphylaxis following immediately to hours after ingesting one structural type of NSAID but not after ingesting structurally unrelated NSAIDs; and 2)Comparatively mild to moderately severe T cell-mediated delayed onset (usually more than 24 hour), skin reactions such as maculopapular rashfixed drug eruptionsphotosensitivity reactions, delayed urticaria, and contact dermatitis; or 3) far more severe and potentially life-threatening t-cell mediated delayed systemic reactions such as the DRESS syndromeacute generalized exanthematous pustulosis, the Stevens–Johnson syndrome, and toxic epidermal necrolysis. Other NSAID hypersensitivity reactions are allergy-like symptoms but do not involve true allergic mechanisms; rather, they appear due to the ability of NSAIDs to alter the metabolism of arachidonic acid in favor of forming metabolites that promote allergic symptoms. Afflicted individuals may be abnormally sensitive to these provocative metabolites and/or overproduce them and typically are susceptible to a wide range of structurally dissimilar NSAIDs, particularly those that inhibit COX1. Symptoms, which develop immediately to hours after ingesting any of various NSAIDs that inhibit COX-1, are: 1)exacerbations of asthmatic and rhinitis (see aspirin-induced asthma) symptoms in individuals with a history of asthma or rhinitis and 2) exacerbation or first-time development of wheals and/or angioedema in individuals with or without a history of chronic urticarial lesions or angioedema.[15]

Contraindications

NSAIDs may be used with caution by people with the following conditions:[6]

Irritable bowel syndrome[6]

Persons who are over age 50, and who have a family history of GI (gastrointestinal) problems[6]

Persons who have had past GI problems from NSAID use[6]

NSAIDs should usually be avoided by people with the following conditions:[6]

Peptic ulceror stomach bleeding[6]

Uncontrolledhypertension[6]

Kidney disease[6]

People that suffer with inflammatory bowel disease (Crohn’s disease or ulcerative colitis)[6]

Pasttransient ischemic attack (excluding ibuprofen)[6]

Paststroke (excluding ibuprofen)[6]

Pastmyocardial infarction (excluding ibuprofen)[6]

Coronary artery disease(excluding ibuprofen)[6]

Undergoingcoronary artery bypass surgery[6]

Taking ibuprofen for heart[6]

Congestive heart failure(excluding low-dose ibuprofen)[12]

In third trimester of pregnancy[6]

Persons who have undergonegastric bypass surgery[13][14]

Persons who have a history of allergic or allergic-typeNSAID hypersensitivity reactions, e.g. aspirin-induced asthma[15]

Adverse effects

The widespread use of NSAIDs has meant that the adverse effects of these drugs have become increasingly common. Use of NSAIDs increases risk of having a range of gastrointestinal(GI) problems.[16] When NSAIDs are used for pain management after surgery they cause increased risk of kidney problems.[17]

An estimated 10–20% of NSAID patients experience dyspepsia. In the 1990s high doses of prescription NSAIDs were associated with serious upper gastrointestinal adverse events, including bleeding.[18] Over the past decade, deaths associated with gastric bleeding have declined.

NSAIDs, like all drugs, may interact with other medications. For example, concurrent use of NSAIDs and quinolones may increase the risk of quinolones’ adverse central nervous system effects, including seizure.[19][20]

There is argument over the benefits and risks of NSAIDs for treating chronic musculoskeletal pain. Each drug has a benefit-risk profile [21] and balancing the risk of no treatment with the competing potential risks of various therapies is the clinician’s responsibility.

Combinational risk

If a COX-2 inhibitor is taken, a traditional NSAID (prescription or over-the-counter) should not be taken at the same time.[22][not in citation given] In addition, people on daily aspirin therapy (e.g., for reducing cardiovascular risk) must be careful if they also use other NSAIDs, as these may inhibit the cardioprotective effects of aspirin.

Rofecoxib (Vioxx) was shown to produce significantly fewer gastrointestinal adverse drug reactions (ADRs) compared with naproxen.[23] This study, the VIGOR trial, raised the issue of the cardiovascular safety of the coxibs. A statistically significant increase in the incidence of myocardial infarctions was observed in patients on rofecoxib. Further data, from the APPROVe trial, showed a statistically significant relative risk of cardiovascular events of 1.97 versus placebo[24]—which caused a worldwide withdrawal of rofecoxib in October 2004.

Use of methotrexate together with NSAIDS in rheumatoid arthritis is safe, if adequate monitoring is done.[25]

Cardiovascular

NSAIDs aside from aspirin, both newer selective COX-2 inhibitors and traditional anti-inflammatories, increase the risk of myocardial infarction and stroke.[26][27] They are not recommended in those who have had a previous heart attack as they increase the risk of death and/or recurrent MI.[28]Evidence indicates that naproxen may be the least harmful out of these.[27][29]

NSAIDs aside from (low-dose) aspirin are associated with a doubled risk of heart failure in people without a history of cardiac disease.[29] In people with such a history, use of NSAIDs (aside from low-dose aspirin) was associated with a more than 10-fold increase in heart failure.[30] If this link is proven causal, researchers estimate that NSAIDs would be responsible for up to 20 percent of hospital admissions for congestive heart failure. In people with heart failure, NSAIDs increase mortality risk (hazard ratio) by approximately 1.2–1.3 for naproxen and ibuprofen, 1.7 for rofecoxib and celecoxib, and 2.1 for diclofenac.[31]

On 9 July 2015, the FDA toughened warnings of increased heart attack and stroke risk associated with nonsteroidal anti-inflammatory drugs (NSAID). Aspirin is an NSAID but is not affected by the new warnings.[32]

Possible erectile dysfunction risk

A 2005 Finnish study linked long term (over 3 months) use of NSAIDs with an increased risk of erectile dysfunction.[33] This study was correlational only, and depended solely on self-reports (questionnaires).

A 2011 publication[34] in the Journal of Urology received widespread publicity.[35] According to this study, men who used NSAIDs regularly were at significantly increased risk of erectile dysfunction. A link between NSAID use and erectile dysfunction still existed after controlling for several conditions. However, the study was observational and not controlled, with low original participation rate, potential participation bias, and other uncontrolled factors. The authors warned against drawing any conclusion regarding cause.[36]

Gastrointestinal

The main adverse drug reactions (ADRs) associated with NSAID use relate to direct and indirect irritation of the gastrointestinal (GI) tract. NSAIDs cause a dual assault on the GI tract: the acidic molecules directly irritate the gastric mucosa, and inhibition of COX-1 and COX-2 reduces the levels of protective prostaglandins. Inhibition of prostaglandin synthesis in the GI tract causes increased gastric acid secretion, diminished bicarbonate secretion, diminished mucus secretion and diminished trophic[clarification needed] effects on epithelial mucosa.

Common gastrointestinal ADRs include:[5]

Nausea/vomiting

Dyspepsia

Gastric ulceration/bleeding[37]

Diarrhea

Clinical NSAID ulcers are related to the systemic effects of NSAID administration. Such damage occurs irrespective of the route of administration of the NSAID (e.g., oral, rectal, or parenteral) and can occur even in patients with achlorhydria.[38]

Ulceration risk increases with therapy duration, and with higher doses. To minimise GI ADRs, it is prudent to use the lowest effective dose for the shortest period of time—a practice that studies show is often not followed. Recent studies show that over 50% of patients who take NSAIDs have sustained some mucosal damage to their small intestine.[39]

There are also some differences in the propensity of individual agents to cause gastrointestinal ADRs. Indomethacinketoprofen and piroxicam appear to have the highest prevalence of gastric ADRs, while ibuprofen (lower doses) and diclofenac appear to have lower rates.[5]

Certain NSAIDs, such as aspirin, have been marketed in enteric-coated formulations that manufacturers claim reduce the incidence of gastrointestinal ADRs. Similarly, some believe that rectal formulations may reduce gastrointestinal ADRs. However, consistent with the systemic mechanism of such ADRs, and in clinical practice, these formulations have not demonstrated a reduced risk of GI ulceration.[5]

Commonly, gastric (but not necessarily intestinal) adverse effects can be reduced through suppressing acid production, by concomitant use of a proton pump inhibitor, e.g., omeprazoleesomeprazole; or the prostaglandin analogue misoprostol. Misoprostol is itself associated with a high incidence of gastrointestinal ADRs (diarrhea). While these techniques may be effective, they are expensive for maintenance therapy.

Inflammatory bowel disease

NSAIDs should be used with caution in individuals with inflammatory bowel disease (e.g., Crohn’s disease or ulcerative colitis) due to their tendency to cause gastric bleeding and form ulceration in the gastric lining. Pain relievers such as paracetamol (also known as acetaminophen) or drugs containing codeine (which slows down bowel activity) are safer medications for pain relief in IBD.[citation needed]

Renal

NSAIDs are also associated with a fairly high incidence of renal adverse drug reactions (ADRs). The mechanism of these renal ADRs is due to changes in renal haemodynamics (kidney blood flow), ordinarily mediated by prostaglandins, which are affected by NSAIDs. Prostaglandins normally cause vasodilation of the afferent arterioles of the glomeruli. This helps maintain normal glomerular perfusion and glomerular filtration rate (GFR), an indicator of renal function. This is particularly important in renal failure where the kidney is trying to maintain renal perfusion pressure by elevated angiotensin II levels. At these elevated levels, angiotensin II also constricts the afferent arteriole into the glomerulus in addition to the efferent arteriole it normally constricts. Prostaglandins serve to dilate the afferent arteriole; by blocking this prostaglandin-mediated effect, particularly in renal failure, NSAIDs cause unopposed constriction of the afferent arteriole and decreased RPF (renal perfusion pressure).

Common ADRs associated with altered renal function include:[5]

Salt (Sodium) and fluid retention

Hypertension(high blood pressure)

These agents may also cause renal impairment, especially in combination with other nephrotoxic agents. Renal failure is especially a risk if the patient is also concomitantly taking an ACE inhibitor (which removes angiotensin II’s vasoconstriction of the efferent arteriole) and a diuretic (which drops plasma volume, and thereby RPF)—the so-called “triple whammy” effect.[40]

In rarer instances NSAIDs may also cause more severe renal conditions:[5]

Interstitial nephritis

Nephrotic syndrome

Acute renal failure

Acute tubular necrosis

Renal papillary necrosis

NSAIDs in combination with excessive use of phenacetinand/or paracetamol (acetaminophen) may lead to analgesic nephropathy.[41]

Photosensitivity]

Photosensitivity is a commonly overlooked adverse effect of many of the NSAIDs.[42] The 2-arylpropionic acids are the most likely to produce photosensitivity reactions, but other NSAIDs have also been implicated including piroxicamdiclofenac and benzydamine.

Benoxaprofen, since withdrawn due to its hepatotoxicity, was the most photoactive NSAID observed. The mechanism of photosensitivity, responsible for the high photoactivity of the 2-arylpropionic acids, is the ready decarboxylation of the carboxylic acid moiety. The specific absorbance characteristics of the different chromophoric 2-aryl substituents, affects the decarboxylation mechanism. While ibuprofen has weak absorption, it has been reported as a weak photosensitising agent.[citation needed]

During pregnancy

NSAIDs are not recommended during pregnancy, particularly during the third trimester. While NSAIDs as a class are not direct teratogens, they may cause premature closure of the fetal ductus arteriosus and renal ADRs in the fetus. Additionally, they are linked with premature birth[43] and miscarriage.[44][45] Aspirin, however, is used together with heparin in pregnant women with antiphospholipid antibodies.[46] Additionally, Indomethacin is used in pregnancy to treat polyhydramnios by reducing fetal urine production via inhibiting fetal renal blood flow.

In contrast, paracetamol (acetaminophen) is regarded as being safe and well-tolerated during pregnancy, but Leffers et al. released a study in 2010 indicating that there may be associated male infertility in the unborn.[47][48] Doses should be taken as prescribed, due to risk of hepatotoxicity with overdoses.[49]

In France, the country’s health agency contraindicates the use of NSAIDs, including aspirin, after the sixth month of pregnancy.[50]

Allergy/allergy-like hypersensitivity reactions

A variety of allergic or allergic-like NSAID hypersensitivity reactions follow the ingestion of NSAIDs. These hypersensitivity reactions differ from the other adverse reactions listed here which are toxicity reactions, i.e. unwanted reactions that result from the pharmacological action of a drug, are dose-related, and can occur in any treated individual; hypersensitivity reactions are idiosyncratic reactions to a drug.[51] Some NSAID hypersensitivity reactions are truly allergic in origin: 1) repetitive IgE-mediated urticarial skin eruptions, angioedema, and anaphylaxis following immediately to hours after ingesting one structural type of NSAID but not after ingesting structurally unrelated NSAIDs; and 2)Comparatively mild to moderately severe T cell-mediated delayed onset (usually more than 24 hour), skin reactions such as maculopapular rashfixed drug eruptionsphotosensitivity reactions, delayed urticaria, and contact dermatitis; or 3) far more severe and potentially life-threatening t-cell mediated delayed systemic reactions such as the DRESS syndromeacute generalized exanthematous pustulosis, the Stevens–Johnson syndrome, and toxic epidermal necrolysis. Other NSAID hypersensitivity reactions are allergy-like symptoms but do not involve true allergic mechanisms; rather, they appear due to the ability of NSAIDs to alter the metabolism of arachidonic acid in favor of forming metabolites that promote allergic symptoms. Afflicted individuals may be abnormally sensitive to these provocative metabolites and/or overproduce them and typically are susceptible to a wide range of structurally dissimilar NSAIDs, particularly those that inhibit COX1. Symptoms, which develop immediately to hours after ingesting any of various NSAIDs that inhibit COX-1, are: 1)exacerbations of asthmatic and rhinitis (see aspirin-induced asthma) symptoms in individuals with a history of asthma or rhinitis and 2) exacerbation or first-time development of wheals and/or angioedema in individuals with or without a history of chronic urticarial lesions or angioedema.[15]

Other

Common adverse drug reactions (ADR), other than listed above, include: raised liver enzymesheadachedizziness.[5]Uncommon ADRs include: hyperkalaemia, confusion, bronchospasm, rash.[5] Rapid and severe swelling of the face and/or body. Ibuprofen may also rarely cause irritable bowel syndrome symptoms. NSAIDs are also implicated in some cases of Stevens–Johnson syndrome.

Most NSAIDs penetrate poorly into the central nervous system(CNS). However, the COX enzymes are expressed constitutively in some areas of the CNS, meaning that even limited penetration may cause adverse effects such as somnolence and dizziness.

In very rare cases, ibuprofen can cause aseptic meningitis.[52]

As with other drugs, allergies to NSAIDs might exist. While many allergies are specific to one NSAID, up to 1 in 5 people may have unpredictable cross-reactive allergic responses to other NSAIDs as well.[53]

Drug interactions

NSAIDs reduce renal blood flow and thereby decrease the efficacy of diuretics, and inhibit the elimination of lithium and methotrexate.[54]

NSAIDs cause hypocoagulability, which may be serious when combined with other drugs that also decrease blood clotting, such as warfarin.[54]

NSAIDs may aggravate hypertension (high blood pressure) and thereby antagonize the effect of antihypertensives,[54] such as ACE Inhibitors.[55]

NSAIDs may interfere and reduce efficiency of SSRIantidepressants.[56][57]

Various widely used nonsteroidal anti-inflammatory drugs (NSAIDs) enhance endocannabinoid signaling by blocking the anandamide-degrading membrane enzyme fatty acid amide hydrolase (FAAH).[58]

How’s that for a warning label?  Did it have enough side effects for you? Think you might need more meds after taking this one? That label was 4094 words long. How many of those do you read? How do you know what you’re doing to your body if you don’t know what you’re putting into it? Do you think it coincidence that Monsanto started their GMO seed about the same time that glycation started being researched? Since much of this kind of research is funded by the industry it affects, I wouldn’t doubt that Monsanto had a hand in this research. This would allow them to immediately file these studies on glycation so that doctors and other scientists couldn’t find them to review. Yet each and every one of these 17,000+ studies have been vetted and examined by the NIH and PubMed. What I want to know is, why weren’t warnings about the glycative affects of glucose revealed at that time? Did Monsanto have anything to do with it?

The above list is the warning label for the adverse effects of Celebrex. Do you take Celebrex? Have you read the above warnings? Use of this drug can only lead to the use of more and more drugs. What do you think that would do for the profits for Monsanto? Do you still think this is coincidence? From renal failure, to the increased risk of myocardial infarction and stroke,[26][27] this drug brings on more drug use, simply so people can get away from their pain, pain caused by consumption of Monsanto’s grains. To me this is completely an unsustainable cycle. It’s a cycle of death and disease, leaving only, people in pain. Where is the sense in keeping this addiction?

Celebrex isn’t the only drug that leads to this interdependent drug abuse orchestrated by Monsanto, Pfizer, Bayer and Syngenta. There is a profitable reason that this cycle continues. Boatloads of investors depend on it. Too bad they don’t know what it’s doing to the society that they have to life in and with.

I propose that we tell Monsanto how we feel about this, not with our voices, but with our mouths in what we eat. Quit eating grains. They’re responsible for nearly all the pain you experience (with the exception of physical injuries).Grains and the glycation they bring, bring also all inflammation that influences all diseases. Stop buying bread, crackers, cookies, anything that flour is used in, stop using it, forever. That’s the only way you can start to free yourself from the addiction. You have to stop buying their junk food. Their junk food is making you sick. It’s making you sicker by the day. Stop it, you have the power to stop it and by stopping it, it gives you power, far more power than what you ever could have imagined you would have.

According to the BJM (British Medical Journal) on Cox 2 inhibitors such as Celebrex,  Selective COX 2 inhibitors are associated with a moderate increase in the risk of vascular events, as are high dose regimens of ibuprofen and diclofenac, but high dose naproxen is not associated with such an excess. How often do you need to take an Advil for your headache? Were you aware of what that painkiller does to your kidneys and liver or how much it increased your odds of having a heart attack? Why weren’t you made aware of that when it was sold to you? Maybe it was. Every drug commercial is primarily a dissertation of the adverse effects and precautions and contraindications each drug has. They all have to include this in all advertising. You’d think that that would dissuade anyone from buying into what has turned out to be nothing more than a perception of health. What drug use leads to is really not relief but continued drug use. It’s called ongoing treatment. Every hospital takes part in it. This is the effect of a society on carbohydrates….a society on drugs.

In all, there were 11,833 studies on PubMed, on the effects of glucose glycating proteins, hemoglobin, and cholesterol dating back to March, 1984. {There were 17628 studies done on PMC.) Incidentally, that was one month after I was released from the hospital after spending a month in a coma and suffering two strokes while comatose. I could have never come back this far without Dr Perlmutter’s help and advice that it was the AGEs that were hindering my recovery. Again, I have to thank you, Dr Perlmutter.

With having the evidence for over 30 years, why hasn’t the public been told about glycation or the AGEs they create prior to Dr Perlmutter’s book, Grain Brain? It’s those AGEs that are at the root of all modern diseases. If this was uncovered 30+ years ago, why have we just found out about it from the bestselling books from two doctors? Was someone trying to hide something? My guess is yes.

This is Monsanto’s path to power and freedom. Their freedom is to wreak whatever havoc they can on your health by masturbating your taste buds with their glucose laden products, so you’ll be buying their pharmaceuticals in the near future. By near, I mean, it only takes a couple days before you’re indebted (addicted). If you want true power and freedom, you can have it in two weeks. That’s how long it takes to break the addiction. Or you can do it with a fast in 3 days.

THE WAY FORWARD – FASTING AND KETOSIS

For 2500 years, physicians have used fasting as a means to find the way back to health, by a simple and inexpensive manner in which one could actually heal themselves from virtually any of the modern diseases that have plagued man, since the dawn of civilization. For me, it’s easy to see the correlation of the emergence of modern diseases with the gradual increase of consumption of einkorn wheat, the precursor to our modern strains of wheat. From Emmer (one of the first domesticated strains) and Durum Semolina which is little higher in gluten yet, it’s still considered a weak wheat. (The wheat doesn’t rise as well as it holds the dough together to hold the pasta shape.) Winter Red, spelt and other bread wheats or common wheats that are higher in gluten have been used for bread for thousands of years because it rises better. Today’s forms of highly modified wheat act nothing like the strains from thousands of years ago as today’s  highly domesticated strains of wheat cannot survive in the wild. That’s according to Wikipedia and that’s due to their inability to disperse their seeds. Monsanto has made certain of that through their genetic modifying to create ender seeds that won’t pollinate so a farmer has no seed for next year’s crop forcing them to buy GMO seed from Monsanto. (GMO by itself is not dangerous. It’s what the modifying allows the farmer to do that makes it dangerous and that’s to spray it with Roundup. Their seed is genetically modified to handle applications of the glyphosate herbicide.) This is the wheat that Monsanto is forcing their farmers to grow for your cereal, bread and snacks. The same exists in the cornfields as well, contaminating every corn chip that you eat. (When was the last time you ate Mexican food?)

But we’re talking about wheat right now which was originally cultivated in the Fertile Crescent 10,000 years ago, approximately the same time that modern disease started showing up in the bones of the remains of the people. This is a clear indication of the glycation that wheat was responsible for even then, even as slow as the einkorn wheat is to digest (which slows the progression of glycation). The glycation existed then as it does now, only it took it much longer to manifest. Today, it manifests itself immediately (as soon as it touches your tongue) and this is due to the fast dissolving gluten flour that’s used for bread and pastries as well as pasta and cereal. It just glycates more now as the grain has changed immensely in the last 10,000 years. As these foods increased in prevalence in our diet, the rates of disease increased, as it’s these grains that have always generated disease. They generate it so slowly that it’s never noticed until it’s too late or you stop eating it. This is the value of fasting and why fasting is so important to the health of anyone on this type of carbohydrate diet.

This is why fasting has always cured disease. 98% of all disease is a direct result of our diet. With that being said, it’s easy to see why removing everything damaging from our diet is going to heal the damage caused by keeping those foods in the diet. Fasting produces such good results it’s been the subject of over 20,000 studies on PMC in the NLM at the NIH. (PMC has reports from across the world. Pubmed has 590 reports from studies done in the US alone.) It’s that important, yet what has your doctor shared with you about this life-saving course of intervention? Your doctor comes into your appointed meeting with his/her prescription tablet in hand ready to prescribe pharmaceuticals. (Now it’s a laptop that affords them more latitude in their diagnosis. I sometimes see a primary care physician who still carries a prescription pad with him everywhere he goes, but then he has drug reps going in and out of his office all the time, so to speak.) Their whole intent is to prescribe drugs for your ailments, which are more than likely caused by the ingestion of grain foods. Prescribing drugs is the way they’re trained to treat patients, not with recommendations for diet. (Monsanto wouldn’t allow that to take place as they have far more control over your life than what you could ever believe.)

That’s exactly why fasting is so healthy. It removes the worst of the toxins in our bodies that are built up from the diets of bread, wheat and grain-based products, and doesn’t put more toxins back in with the prescribed drugs. Those grain products also happen to be the most addictive, which is what makes them the hardest to give up. The addictive nature of sugar, at its worst, is displayed in this manner (when it drives pharmaceuticals). When one fasts, they give up the sugars that are doing all the glycating and it’s this glycation that is at the root of all disease and this is why going without food is so healthy.

It also sets your body up for future health by resetting the hormonal structure in your body. This is mostly the result of your hormones transitioning to a starvation mode of survival, where the Ghrelin your stomach releases, sends this growth hormone throughout your body allowing them to do their magic in repairing damage and extending cell life where cell death took place before. (This is directly due to the carbohydrate influence in the diet, creating glycation.) It’s the elimination of glycation that initially brings back a resemblance of health but that’s not what brings future health. It’s the breaking of an addiction. This addiction is built into our society so much, It starts in our prenatal body and continues through the first year of life and then on. (This is due to the prevalence of sugar and high fructose corn syrup in baby foods, formula and infant medicines.) The prenatal starts with mama diet before you’re born, if your mother ate carbs, you got them before you were born. But that only explains why you’re dependent. It doesn’t explain how to break the dependence. That’s with fasting and the keto diet, or ketogenic diet (the diet our ancestors were on ever since our existence). The keto involves fasting as part of the diet, making it much easier to maintain. (There’s no hunger.) Fasting does that by sending your body into ketosis.

According to Wikipedia; in the early 20th century around 1911; Bernarr Macfadden, an American exponent of physical culture, popularized the use of fasting to restore health. His disciple, the osteopathic physician Hugh Conklin, of Battle Creek, Michigan, began to treat his epilepsy patients by recommending fasting.  Conklin conjectured that epileptic seizures were caused when a toxin, secreted from the Peyer’s patches in the intestines, was discharged into the bloodstream. Conklin’s fasting therapy was adopted by neurologists in mainstream practice. In 1916, a Dr. McMurray wrote to the New York Medical Journal claiming to have successfully treated epilepsy patients with a fast, followed by a starch- and sugar-free diet, since 1912. In 1921, prominent endocrinologist H. Rawle Geyelin reported his experiences to the American Medical Association convention. He had seen Conklin’s success first-hand and had attempted to reproduce the results in 36 of his own patients. He achieved similar results despite only having studied the patients for a short time. He reported that three water-soluble compounds, β-hydroxybutyrateacetoacetate and acetone (known collectively as ketone bodies), were produced by the liver in otherwise healthy people when they were starved or if they consumed a very low-carbohydrate high-fat diet.

With fasting being able to eliminate so many disorders, a path was sought to bring this form of healing to the mainstream by creating a diet to encourage fasting. Thus the ketogenic diet was born in 1921 through the efforts of Russel Wilder. According to Wikipedia, Russel Wilder, at the Mayo Clinic, built on this research and coined the term ketogenic diet to describe a diet that produced a high level of ketone bodies in the blood (ketonemia) through an excess of fat and lack of carbohydrate.

Fasting is the quickest manner in which to allow your body to go into ketosis, yet it may not be the easiest. Although on second thought, being the quickest way may make it the easiest. I went through two weeks of withdrawal because I couldn’t give up all foods I loved to eat all at once, to allow my body to go into ketosis in a few days. I could have avoided 10 days of want by fasting and only want something to eat for a few days, as what happens when you fast for a minimum of 3 days. A longer fast is more beneficial but the three days allows your body to respond by going into ketosis which is a fat burning mode. It’s this fat burning mode that forces your body to make its own glucose, which is a much cleaner glucose than you get from the sugar you eat, as it’s a clean glucose made from your own glycogen or fat storage. Getting into ketosis quicker could allow you to start your fat burning diet, but continuing some carbs will only make the withdrawal more difficult as it may drop your body back out of ketosis. This was my problem and why my transition took so long. (Thankfully, they’ll be no next time.)

Ketosis refers to acids in the body that are derived and used while in a state of low glucose in the blood. Because my body has been in a state of ketosis for the last 3 years, I feel qualified to speak about this lifestyle. I call it a lifestyle because it really is. It’s a lifestyle completely different from the lifestyle of a carboholic. Carboholics require food every other hour or so, it’s the law of glucose consumption, appetite follows glucose levels in the blood. It’s that simple, blood sugar levels rise and satiety sets in, releasing hormones controlling feel-good emotions influencing behavior, sometimes unrecognizable behavior. But, that usually happens when the blood sugars fall again after a couple hours releasing hormones of hunger, need and want. These hormones are completely different than the satiety hormones and have a much different effect on the body.

This is where carboholics do not have the advantage that ketonemiacs have. Ketonemiacs (those who have allowed their bodies to go into a state of ketosis) aren’t controlled by their hormones, so they don’t have to follow any hunger cycle. They’re in full control of their hormones. This also means that they’re in more control of their emotions because of that. I know that it doesn’t sound like it’s that big of a deal, but it’s more important than you ever could imagine.

First, let’s look at the state of ketosis, as explained in Wikipedia;

Ketosis is a metabolic state in which most of the body’s energy supply comes from ketone bodies in the blood, in contrast to a state of glycolysis in which blood glucose provides most of the energy. Ketosis is similar to a condition called ketoacidosis, in that both cause a side effect known to laypeople as acetone breath.”

“Longer-term ketosis may result from fasting or staying on a low-carbohydrate diet, and deliberately induced ketosis serves as a medical intervention for various conditions, such as intractable epilepsy, and the various types of diabetes. In glycolysis, higher levels of insulin promote storage of body fat and block the release of fat from adipose tissues, while in ketosis, fat reserves are readily released and consumed. For this reason, ketosis is sometimes referred to as the body’s “fat burning” mode.”

Even bodybuilders have recognized ketonemia as being the most beneficial state to keep their body in as it’s in this state where they produce more growth hormones because of the amount of Ghrelin their stomachs release to enable them to grow their muscles bigger without the carbs.

It used to be one of the biggest problems, being in a state of ketosis is often confused with ketoacidosis, which has nothing to do with being in a state of nutritional ketosis. Ketoacidosis is a state of extreme ketosis that can only happen to type 1 diabetics because their pancreas is incapable of secreting enough insulin to handle even a large amount of glucose in the system. Because of this the liver of type 1 diabetics secretes more ketones than what the body needs to operate.  Again Wikipedia says on the subject of ketosis;

“Ketosis is deliberately induced by use of a ketogenic diet as a medical intervention in cases of intractable epilepsy. Other uses of low-carbohydrate diets remain controversial.[15][16] Induced ketosis or low-carbohydrate diet terms have very wide interpretation. Therefore, Stephen S. Phinney and Jeff S. Volek coined the term “nutritional ketosis” to avoid the confusion.[17]Although I appreciate ketosis as being a “fat burning mode”, it’s the other benefits that I appreciate more. Benefits like less pain, no headaches, no stomachaches, far more energy than what I’ve ever had, ability to get more work done, as I don’t have to stop all the time to eat and although I do eat at my desk, I’m usually at my desk 16-18 hours out of the day, except on therapy days. I take 3 hours, 3 days a week for therapy. My therapy is exercise. My brain needs it, but my body benefits.”

Ketoacidosis is a metabolic state associated with high concentrations of ketone bodies, formed by the breakdown of fatty acids and the deamination of amino acids. Ketoacidosis is most common in untreated type 1 diabetes mellitus, when the liver breaks down fat and proteins in response to a perceived need for respiratory substrate. Prolonged alcoholism may lead to alcoholic ketoacidosis. “

“In diabetic ketoacidosis, a high concentration of ketone bodies is usually accompanied by insulin deficiency, hyperglycemia, and dehydration. Particularly in type 1 diabetics the lack of insulin in the bloodstream prevents glucose absorption, thereby inhibiting the production of oxaloacetate (a crucial precursor to the β-oxidation of fatty acids) through reduced levels of pyruvate (a byproduct of glycolysis), and can cause unchecked ketone body production (through fatty acid metabolism) potentially leading to dangerous glucose and ketone levels in the blood. Hyperglycemia results in glucose overloading the kidneys and spilling into the urine (transport maximum for glucose is exceeded). Dehydration results following the osmotic movement of water into urine. (Osmotic diuresis), exacerbates the acidosis.”

“I bring this up to make the point that nutritional ketosis is not ketoacidosis. It’s far from it. According to Wikipedia again, “Normal serum reference ranges for ketone bodies are 0.5–3.0 mg/dL, equivalent to 0.05–0.29 mmol/L.[23]” In ketosis, the levels range from 3 – 6 mg/dL. Ketoacidosis requires a level of 15 – 25 mg/dL, more the three times needed for ketosis, making it virtually impossible for anyone to into ketoacidosis if you’re not a type 1 diabetic. Type 1 diabetics are required to make sure their bodies don’t produce many ketones because of the risk of ketoacidosis”.

According to PMC’s report on Calorie Restriction (CR) or fasting, submitted; July 2010; Nevertheless, ongoing research continues to draw a more complete picture of CR at the molecular level, which may ultimately allow for the development of therapeutics that might be able to confer at least some of the health benefits of this dietary regimen.

Remaining in a state of ketosis, on the other hand, has allowed my body to regain that which was lost 31 years ago in a car accident that left me severely disabled because of a severe closed head injury, (It was the two strokes that were the most devastating.)

It’s become evident to me since I’ve been carb free and in a state of ketonemia or ketosis, how much our society is addicted to this drug (sugar/glucose/fructose) that does little more than to lead those who eat it to further drug use. Our food industrial complex sees to that by their advertising. I’m convinced it’s because they’re associated with the pharmaceutical industry. They used to be merged into one corporation that controlled the seed supply for the farmers as well as the pharmaceuticals that treated to pain and discomfort brought on by the products grown by the crop seed sold to the farmer to supply the grains for the snack foods everyone everywhere loves to eat.

The unfortunate result of this love affair with those snack and comfort foods is what this diet brings, as its cost of this pleasure. The price to be paid is in the discomfort that this food brings to all those who eat it, regardless of how much they eat. The food industry (Monsanto in particular) has a fortune invested in keeping you eating this deadly food. They’ve built an industry just to treat diabetes, with all the glucose meters and pumps out there, just so addicts can get their next fix. The trouble this industry goes to just to keep their addicts happy. I know now. I didn’t 4 years ago when I was an addict.

The less an addict consumes at each, sitting dictates how much damage it’s going to do, but it’s going to do damage. There is no way to avoid it. That’s the way our digestion and metabolism works. That’s why this addiction is by far, the worst addiction our society has to deal with. This addiction leads to every other addiction that we’re actively fighting, including alcoholism, heroin and tobacco and even gambling. Yes, even gambling, as gambling is driven by the hunger cycle which is one of the biggest underlying influences of a carbohydrate diet. Hunger in this diet drives absolutely everything, even breathing, and because of that, eventually drugs.

This is a cycle that I don’t need. As a matter of fact, it’s the last thing I need. The biggest reason I refuse to take any of these drugs anymore is that all of them carry side effects, some major, some minor. Whether the side effects are major or minor, I don’t want to experience any of them, anymore. I’ve had my fill of side effects, especially the ones that make my health worse, which is where most of these side effects should be classified. After living for twenty years needing to take massive amounts of opioids for my chronic severe pain, diuretics for my high blood pressure, anti-depressants for the pain, and living with the side effects of not only the opioids, but every other drug they had me on, all twelve of them, I got fed up with it. I wasn’t going to take it anymore as I just couldn’t afford it. And I was only up to twelve medications. I have a friend who’s on this diet, who’s lowered his needs to thirteen daily medications from twenty-three. How many meds do you take every day? How many would you like to do without, if your health would allow? This is where fasting needs to replace doping. A change in diet will go much further than any drug and the cure lasts longer than any treatment.

I live by the theory that if the meds aren’t needed in the first place, my health is going to be that much better. That is why I removed everything from my diet that I could, that is responsible for these horrendous diseases, requiring the need for these medications. By fasting, one can reach this healing state much quicker than I did, just by cutting my bread. Where it took me two weeks to get into full ketosis, by fasting I could have jump-started the state by starving my body, then gone on from there with my ketogenic diet to keep my body in this healing state. This is the advantage of fasting, it not only starts the healing from the beginning by putting your body in a starvation mode, it allows you to stay in that mode for the rest of your life. That one little option in itself is what’s going to extend your life beyond 100 years. I can see where ultimately man will be able to extend its lifespan to over 150 years old. !00 years from now, when all mankind is on a ketogenic or paleo diet again, I can see the oldest people in the world living into their 180’s, doubling today’s average lifespan.

This can be easily obtained simply by allowing our bodies to heal themselves and not keep depending on drugs for the perception of healing, which ultimately brings nothing but more drug use, which ultimately is what ruins the liver and kidneys leading to all the cancers and disorders of the hepatic and renal systems. It’s this drug dependence that driven by another dependence that we’ve all been born into. I hope that you’re beginning to see how our drug addictions are driven by one thread that drives all modern diseases along with it.  That one thread is what ties 100% of all cancers, 98% of all heart diseases, and 99.9 % of all dementia, all arthritis, all headaches, and almost all stomachaches together is one substance that can be removed from the diet without any severe side effects. I shouldn’t need to tell you what that substance is by now. You should know. You eat it every day. You live with the effects of addiction. Pain always comes with addiction. (That’s what makes breaking the addiction rewarding, limiting the pain cycle. Oh what sweet bliss!)

The idea then is to limit to minuscule amounts, the foods that make up these addictive substances. You should know by now what these foods are, you eat them every morning, either in your coffee as creamer, in the toast you have, or the cereal you consume. You have it every lunch with your sandwich or burrito and with every dinner with your rolls. I have known several families that would just put a plate of bread on the table every evening. This is the display of addiction, a full out need to satisfy the taste buds by dumping more and more sugar in the body, usually in the form of starchy carbs. I’ve also noticed that in those houses that served bread there was always beer cans in the garbage indicating another addiction. If you remove one addiction from our society, you remove all addictions, as this addiction to sugar and carbs is the foundation of all other addictions as they are all based on a hunger cycle which is the result of an addiction to sugar. Does that make it the root of all evil?

I hope that you can see now that it’s this addiction to sugar and carbs that are driving the pharmaceutical industry, and that both industries are driven by the same people who have a major influence in the offices of the agencies that are supposed to regulate this industry, the FDA and the USDA. With that kind of influence, there’s only one way to fight it and that’s to not buy into it. To not buy into it does require a diet of grain abstinence, though. That requires breaking the addiction and moving to as, ketogenic of a diet, as possible. The easiest manner to do this is to do a strict three day, water only fast. The longer you can do it the better, but it must be at least 3 days with absolutely no food. (That’s why it’s important to check with your doctor first).

All of the consumption of the grain industry’s products is what’s driving the pharmaceutical industry today, tomorrow, next year, and for the next 500 and beyond. If we don’t put an end to this now, our society is doomed to suffer the consequences of a carbohydrate addiction that no one is responsible for. The greed of the grain industry combined with the ambition of the pharmaceutical industry has made us all carboholic slaves to the desires these industries. It’s these industries that are rewarding from the most, from this arrangement. For me, it’s scary, how much power we’ve given these industries, simply because we listen to their advertising. We’ve also let them take over the regulating agency that’s supposed to control this industry. Because our health depends on it, we can’t allow Monsanto to dictate how there are going to poison our food, so they can bolster the profits of the pharmaceutical industry.

Not knowing what you put in your body can cost you your life. It is costing you your life if you eat carbs. Those who listen to the advertising and are influenced by it, fall prey to that influence and become their slaves for life or until they quit consuming the grains. There’s very little different than that of alcoholism except that it’s pretty much forced upon us, in our baby food. Feed your babies on your own milk, if you want them to be healthy.

I know what you’re thinking right now, what are all the foods involved in this addiction? The list is enormous and that’s why this is such a dangerous addiction. This industry has virtually forced us to celebrate this addiction. It involves every one of our holidays, with the holiday season being the worst. Every celebration involves some form of sugar. From the Sugar Bowl to the Tostido’s Fiesta Bowl, our celebration is never-ending. Just after the “holiday season” comes Valentine’s Day barely a month later. Then, comes Easter and spring break. Are you beginning to understand why this addiction is our worst? With all the celebrating we need to keep this addiction, how do you change tradition without changing the world? The quickest way that I know is to organize an international health weekend, for 3 days, where everyone goes keto to heal their diseases and give their bodies a chance to go into ketosis, the ever healing state of metabolism.

The nicest advantage of this diet is the amount of control it gives you over your own emotions. You may think that you control your emotions right now, but I can tell you with full confidence, if you’re on a carb diet, you have no control over your emotions. They’re completely controlled by what you eat because what you eat controls your hunger cycle and it’s your hunger cycle that drives every other cycle your body goes through. Since your hunger cycle is controlled by your hormones (mostly leptin and ghrelin), it’s these hormones that are controlling your emotions. You know this every time you crave that bagel or biscotti. Once you bite into it, your saliva starts digesting that instantly gratifying food to give you that aww feeling, that instantly hits your brain, even before you can swallow it. This is your first sign of addiction and dependence that only gives you the perception that you have control of your own emotions. It’s this cycle that is in full control of your emotions. As much as you try to control them, too often they have a tendency to slip out of your control and back into theirs.

Anyone who can’t control their emotions entirely by themselves is a slave to their own hormones. This makes every carboholic a slave to their emotions and therefore a slave to these industries. This displays the dependence of the hunger cycle and the carb diet that drives that hunger cycle. You may not classify these as emotions, but I submit that they actually are. Satiety is defined as the state of being satisfied. If that is not an emotion, as it expresses feelings of calmness and security, I don’t know what is. Hunger, on the other hand, is defined as a strong desire. Is not that an emotion? These emotions are controlled by both leptin and ghrelin, which ultimately are controlled by the grain industry, more than anything else. This is the ruse I refuse to take part in. I can’t afford this trap anymore. The only way out for our society is to break the hold of this industry, to let them know that we’re not going to stand for this kind of abuse. To go ketogenic in your diet is the best way you can get yourself to everlasting health.

With emotions being controlled by our hormonal balance like this, it’s easy to see how carbs could influence that balance. For this to not have an effect on our behavior is beyond comprehension. It has to. When you combine the drive of an addiction (which is what we’re talking about) with the advertisements promoting that addiction, how can it not have an effect on our health and ultimately our society? That is why I make the statement that this cycle has to change. If it doesn’t cease, our health as a society will never get better. There’s never been a better time for a cure, and that cure is a ketogenic diet, not only for each and everybody to be as healthy as possible, but also to regain the health of our whole society. Can you imagine a world where everyone not only controls their own emotions but they’re in control of their emotions? (That includes reactions.)

Let’s go back to addiction, though, for you may still not consider this an addiction. I understand that few caught in an addiction can recognize that addiction when they’re feeding it because the addiction has ways of hiding itself. You can ask anyone who has to have at least one beer a day. They’re not addicted to their beer, as far as they’re concerned, yet they have to have it. And often they don’t even drink more than just one. But they still have to have that one. That is what makes it an addiction. The body can and does live much better without beer, so it’s not a substance the body requires to survive. Yet the beer drinker needs that daily beer to satisfy their addiction. To go without, many times causes more problems because of the work your hormones are doing on your emotions and worse yet your actions by controlling how receptors work in your brain. That makes it a natural thing that you need to do, and not an addiction, to appease that desire to drink the beer. This is how addiction works and it happens to carboholics too. I know I am a carboholic. The desire for sweets is still with me. It’s a last refuge of my addiction. It’s something that I get to fight for the rest of my life.

The fact of the matter is, if you were fed baby food, you’ve been fed carbs, on the premise that this food is healthy to eat. Actually, you’ve been sold that this is the only healthy food to eat. Fault has been found in every other type of nutrition except grains until recent history. For more than 60 years, we’ve been told to eat grains. Thirty years ago, they said whole grains are healthy. They still say, ”whole grains are healthy”, yet according to all the studies I’ve seen out of the hundreds I‘ve looked at, nothing about this food is safe to ingest, leaving me to wonder why do they still recommend it. Then I look at who controls the FDA, the USDA and what interest they have in their industrial farming, and it becomes pretty clear whose influence this is, controlling what we eat.

This simple little act of feeding your baby formula laced with sugars to get you to eat it has addicted you to a lifetime of dependence. It addicted me. Even though I broke the addiction, I’m still affected by what control it did have over me. That’s exactly why I’m pleading with you, don’t let it control you. I can virtually guarantee that you won’t like the end results. Whether they come late or soon, they always come.

When I think about this, my first response is to get angry, for I never asked for this nor could I ever wish for it, or wish it upon anyone else. Yet, there is an industry that is committed to not only continuing this pattern, they’re goal is to increase its scope. You can see this in all the advertising. This is your grain industry pushing this celebration of this addiction and you’re buying into it every time you feed your carb diet, by buying all your snacks, pasta, cereal, soft drinks, and beer, just for starters. I’d go on with the rest but space limits that list in this book. You can find it in both my first and second books, It’s Time for a Cure and Time for the Ultimate Cure. Your best guide is to use the glycemic index as your guide for what foods that are safe to eat or not. It’s the general consensus that you should keep your foods lower than 50 on the glycemic index. My contention is to keep carbs out of your diet completely and let your body make its own glucose. The reason you want to keep your blood glucose low is to avoid the hunger cycle. The hunger cycle is emotionally the worst manifestation of a carb diet. As it controls your emotions, it controls your actions and reactions. This is an undeniable truth. You know it as well as I do. You feel it every time you taste that divine taste when you bite into it, MMM how good it is.

This is where you need to ask yourself, what is it you crave most? If what you crave has any carbohydrate in it, then that’s your first indication that you’re addicted. What kind of carb you crave, quite often tells how bad your addiction is. One wouldn’t think that a hamburger could be a sign of addiction, when actually when you think about the taste you crave, it’s a combination of everything including the bun, which happens to be the addictive ingredient in the hamburger. Everything else in the hamburger is healthy. It’s just the gluten in the bun that’s so addictive. I wouldn’t doubt that they use extra high gluten bread dough for the buns used for these sandwiches, as it’s more addictive, due to the high gluten content. I know they use high gluten bread dough for making pizza dough because it needs to rise, and the more the gluten the better it rises. That makes it taste better, but it also makes it more addictive. That’s why when you’re at one of these restaurants, most everyone there is overweight. They’re there because they crave that high gluten bread dough. You get it in both pizzas and fast food hamburgers. This is how they make you repeat customers.

If you think my assessment is wrong, just try eating your favorite hamburger between two slices of lettuce. The taste is completely different. Most fast food restaurants offer low carb sandwiches but few order them. The only ones that I know of who order them are those who suffer from celiac disease. I believe that all of us suffer somewhat from celiac disease. I think that there are only a very few that can get through life with showing or suffering the effects of a carb diet….especially an excessive carb diet as is the case with most people worldwide today. The reason you crave the taste of the hamburger is that of the high gluten bread dough the buns are made from because it’s that bun that raises your blood glucose as soon as it hits your tongue. Therein lies the addictive nature of glucose, the constant tug on your hunger cycle. It’s caused by the foods you eat if you’re on a carb diet. When you stop to think about it, you know it, as well as I. You just need to do something about it, as I did, three years ago, and then again one year ago when I went complete keto. It took me three years to go completely keto. You can do it in one month if you’ve got the guts to do a thirty day fast. I didn’t and I may have suffered because of it. I guess I was still persuaded to eat the carbs even after I gave up the bread. If I had to do it over again, I’d fast, to go keto. The adjustment is a lot quicker. The adjustment is equivalent to breaking the addiction.

What do you think they’re advertising when they show you those commercials for pizza and their soft drinks, fruit drinks, cereals, breads, pastas, pastries, candy, etc, etc? They selling you that mmmm feeling of dependence and addiction. It’s that feeling you get as soon as your favorite food hits your tongue and makes you go “oh, I needed that”. That’s the same feeling a junkie feels when he gets his latest fix.

They’re using your emotions to control your behavior. That’s because they can. They already control your hormones and it’s your hormones that control your emotions. Is it any wonder that so many are addicted? Our food industry has done their absolute best to sell you their goods, and that means playing to your emotions in order to sell you that great taste that’s going to bring you oh so much discomfort, pain and disease. If you had known that this could and would happen to any one of your kids, you’d do everything in your power to change it. You do have the power to change it, every time you go to the store. Read the label of everything you buy. If it contains wheat, corn, soy or grains at all, don’t buy it. If you do, you’ll be buying into a lifetime of pain and discomfort for your family. Choose something else to feed your family. You’ll be much further ahead in the long run. The money it will save you in pharmaceuticals is nothing short of astounding.

In my estimation, this is criminal behavior. It’s criminal behavior being done on an industrial level. Monsanto has politically engineered their control of the FDA and USDA to ensure their compliance in their dominance of our food supply.

That is why I included my third chapter on our celebration of our addiction. Corporate does this on purpose. They do this because they know that we are addicted by our rate of consumption of their wares. They also know that with their lobbying power, they can get away with virtually anything. It’s kind of the same situation as that of the military-industrial complex. They support congressmen and senators in every state and district, securing their interests, with this influence. Monsanto has even gone to the extent of contracting every farmer that they can, even to the point of suing farmers, just to corner the market. The last corporations that got away with this kind of behavior were busted up by Teddy Roosevelt in the late 19th century. No industry in our history has had more influence on our health, either as an individual or as a society than this grain and sugar industry has with it addictive food. It’s created a multi-trillion dollar medical and pharmaceutical industry. The thing that scares them the most is the ketogenic diet as it’s the only diet that can save you and the world, from their clutches.

We allow these corporations to addict us, even worse than we’ve been any time in the history of man, for which we should be ashamed. I would be but I didn’t set up the Supreme Court to allow Monsanto to patent life in patenting GMO seeds. This may end up being the bane of mankind, as it is a very deadly path for our food industry to be taking. But then it’s only deadly to those who buy into it. That’s why I won’t.