Tag Archives: GHRH

Why I Stay in Ketosis.

Why I Stay in Ketosis.

Ketosis refers to acids in the body that are derived and used while in a state of low glucose in the blood. Because my body has been in a state of ketosis for the last 3 years, I feel qualified to speak about this lifestyle. I call it a lifestyle because it really is. It’s a lifestyle completely different from the lifestyle of a carboholic. Carboholics close-up-fast-food-snacks-behind-no-symbol-low-carb-diet-fattening-unhealthy-eating-concept-deep-fried-squid-rings-french-65973872require food every other hour or so, it’s the law of glucose consumption, appetite follows glucose levels in the blood. It’s that simple, blood sugar levels rise and satiety sets in, releasing hormones controlling feel-good emotions influencing behavior, sometimes unrecognizable behavior. But, that usually happens when the blood sugars fall again after a couple hours releasing hormones of hunger, need and want. These hormones are completely different than the satiety hormones and have a much different effect on the body.

According to PubMed, on the subject of ketosis;

“Hunger and satiety are two important mechanisms involved in body weight regulation. Even though humans can regulate food intake by will, there are systems within the central nervous system (CNS) that regulate food intake and energy expenditure. This complex network, whose control center is spread over different brain areas, receives information from adipose tissue, the gastrointestinal tract (GIT), and from blood and peripheral sensory receptors. The actions of the brain’s hunger/satiety centers are influenced by nutrients, hormones and other signaling molecules. Ketone bodies are the major source of energy in the periods of fasting and/or carbohydrate shortage and might play a role in food intake control.” hormones-list-ghrh-papers-tablet-words-growth-hormone-releasing-hormone-medical-concept-55856070

They go on to say; “Glucose also exerts a hormonal-like action on neurons; electrophysiological recordings demonstrated, for example, that hypoglycemia activates growth hormone-releasing hormone (GHRH) neurons, suggesting a mechanistic link between low blood glucose levels and growth hormone release (Stanley et al., 2013).”

This is where carboholics cannot have the advantages that being in a state of nutritional ketosis has. Those who chose to live in a state of ketosis) aren’t controlled by their hormones, so they don’t have to follow any hunger cycle. They’re in full control of their hormones. With hormones being the primary driver of appetite (leptin), they influence your appetite more than anything and are able to alter your ability to discern whether you need to eat or not. It’s called leptin resistance and we’ll get deeper into that later.

This also means that these hormones are in control of your emotions, because of that. I know that it doesn’t sound like it’s that big of a deal, but it’s more important than you ever could imagine. As I explained in Why the addiction is so hard to break and it has to do with how your hormones control your actions without you realizing it.

First, let’s look at the state of ketosis, as explained in Wikipedia;

Ketosis /kᵻˈtoʊsᵻs/ is a metabolic state in which most of the body’s energy supply comes from ketone bodies in the blood, in contrast to a state of glycolysis in which blood glucose provides most of the energy. Ketosis is similar to a condition called ketoacidosis, in that both cause a side effect known to laypeople as acetone breath.”

“Longer-term ketosis may result from fasting or staying on a low-carbohydrate diet, and deliberately induced ketosis serves as a medical intervention for various conditions, such as intractable epilepsy, and the various types of diabetes.[6] In glycolysis, higher levels of insulin promote storage of body fat and block release of fat from adipose tissues, while in ketosis, fat reserves are readily released and consumed.[5][7] For this reason, ketosis is sometimes referred to as the body’s “fat burning” mode.[8]

This biggest problem with being in a state of ketosis is that it is often confused with ketoacidosis, which has nothing to do with being in a state of nutritional ketosis. Ketoacidosis is a state of extreme ketosis that can only happen to type 1 diabetics because their pancreas is incapable of secreting enough insulin to handle even a small amount of glucose in the system. Because of this the liver of type 1 diabetics secretes more ketones than what the body needs to operate.  Again Wikipedia says;

“Ketosis is deliberately induced by use of a ketogenic diet as a medical intervention in cases of intractable epilepsy.[12] Other uses of low-carbohydrate diets remain controversial.[15][16] Induced ketosis or low-carbohydrate diet terms have very wide interpretation. Therefore, Stephen S. Phinney and Jeff S. Volek coined the term “nutritional ketosis” to avoid the confusion.[17]

Although I appreciate ketosis as being a “fat burning” mode, it’s the other benefits that I appreciate more. Benefits like less pain, no headaches, no stomachaches, far more energy than what I’ve ever had, ability to get more work done, as I don’t have to stop all the time to eat and although I do eat at my desk, I’m usually at my desk 16-18 hours out of the day, except on therapy days. I take 3 hours, 3 days a week for therapy. My therapy is exercise. My brain needs it, but my body benefits.

Ketoacidosis is a metabolic state associated with high concentrations of ketone bodies, formed by the breakdown of fatty acids and the deamination of amino acids. Ketoacidosis is most common in untreated type 1 diabetes mellitus, when the liver breaks down fat and proteins in response to a perceived need for respiratory substrate. Prolonged alcoholism may lead to alcoholic ketoacidosis. “

“In diabetic ketoacidosis, a high concentration of ketone bodies is usually accompanied by insulin deficiency, hyperglycemia, and dehydration. Particularly in type 1 diabetics the lack of insulin in the bloodstream prevents glucose absorption, thereby inhibiting the production of oxaloacetate (a crucial precursor to the β-oxidation of fatty acids) through reduced levels of pyruvate (a byproduct of glycolysis), and can cause unchecked ketone body production (through fatty acid metabolism) potentially leading to dangerous glucose and ketone levels in the blood. Hyperglycemia results in glucose overloading the kidneys and spilling into the urine (transport maximum for glucose is exceeded). Dehydration results following the osmotic movement of water into urine. (Osmotic diuresis), exacerbates the acidosis.”

I bring this up to make the point that nutritional ketosis is not ketoacidosis. It’s far from it. According to Wikipedia again, “Normal serum reference ranges for ketone bodies are 0.5–3.0 mg/dL, equivalent to 0.05–0.29 mmol/L.[23]

In ketosis, the levels range from 3 – 6 mg/dL. Ketoacidosis requires a level of 15 – 25 mg/dL, more the three times the levels needed for ketosis, making it virtually impossible for anyone to go into ketoacidosis if you’re not a type 1 diabetic. Type 1 diabetics are required to make sure their bodies don’t produce many ketones because of the risk of ketoacidosis.

Remaining in a state of ketosis, on the other hand, has allowed my body to regain that which was lost 31 years ago in a car accident that left me severely disabled because of a severe closed head injury, (It was the two strokes that were the most devastating.)

Probably the first and foremost reason I choose to remain on this diet is explained by my lack of need for any of these diabetes medications. I just can’t afford them or the side effects that they carry with them;

  1. insulin
  2. exenatide
  3. liraglutide
  4. pramlintide
  5. Biguanides
  6. metformin
  7. PhenforminPhenformin (DBI) was used from the 1960s through 1980s but was withdrawn due to lactic acidosis risk.[4]
  8. Buformin – also was withdrawn due to lactic acidosis risk.[5]
  9. Thiazolidinediones;
  1. Rosiglitazone – (Avandia): the European Medicines Agency recommended in September 2010 that it be suspended from the EU market due to elevated cardiovascular risks.[7]
  2. Pioglitazone
  3. Troglitazone – (Rezulin): used in 1990s, withdrawn due to hepatitis and liver damage risk[8]
  4.  Peptide analogs;

Secretagogues;          First-generation agents

  1. tolbutamide
  2. acetohexamide
  3. tolazamide
  4. chlorpropamide

Second-generation agents;

  1. glipizide
  2. glyburide or glibenclamide
  3. glimepiride
  4. gliclazide
  5. gliquidone
  6. Meglitinides
  7. repaglinide
  8. nateglinide
  1. Alpha-glucosidase inhibitors
    1. miglitol
    2. acarbose
    3. voglibose
  1. Injectable Amylin analogues
    1. Amylin
    2. pramlintide
  2. SGLT-2 inhibitors

Common generic names for many of these medicines are from Wikipedia;

Many anti-diabetes drugs are available as generics. These include:[35]

No generics are available for dipeptidyl peptidase-4 inhibitors (Januvia, Onglyza) and other combinations.
The above medications are used for diabetes alone. This small list is quite possibly the smallest list that one will need to choose from with a continued diet of carbohydrates. Larger lists exist for heart disease, cancer, high blood pressure, high cholesterol, arthritis, and dementia. That only covers the prescription medication. For OCD medication, you have to consider NSAIDs, the most used pain relievers all carrying more side effects to create more need for further medication. And don’t forget Tylenol. How many problems does that drug have with liver toxicity? It’s been responsible for a few deaths. Then we have to look at the Antacids and all the stomach medicine that’s on the shelf. There are plenty of them and I can honestly tell you right now that 90% of these medications are not necessary unless you’re on a carbohydrate diet. I haven’t used any of these medications in 3 years since I gave up the bread and carbs. I used to have two or three volumes of drug catalogs full of pharmaceuticals that are needed to treat all of the diseases that are caused by the consumption of grains, from diabetes to dementia to heart disease and cancer. My first post lists all of those.

I refuse to take any of these drugs anymore because all of them carry side effects, some major, some minor. Whether the side effects are major or minor, I don’t want to experience any of them. I’ve had my fill of side effects, especially the ones that make my health worse, which is where most of these side effects should be classified. After living for twenty years needing to take massive amounts of opioids for my chronic severe pain, diuretics for my high blood pressure, anti-depressants for the pain, and living with the side effects of not only the opioids but every other drug they had me on, all twelve of them. I’m fed up with it. I’m not going to take it anymore. And I was only up to twelve medications. I have a friend who’s on this diet, who’s lowered his needs to thirteen daily medications from twenty-three. How many meds do you take every day?

I live by the theory that if the meds aren’t needed in the first place, my health is going to be that much better. That is why I removed everything from my diet that I could, that is responsible for these horrendous diseases, requiring the need for these medications. The one thread I found that ties 90% of all cancers (even lung cancer), 90% of all heart diseases, and 99.9 % of all dementia, all arthritis, all headaches, and almost all stomachaches together is one substance that can be removed from the diet without any severe side effects. I shouldn’t need to tell you what that substance is by now. You should know. You eat it every day. You live with the effects of addiction. Pain always comes with addiction.

You eat it every morning, either in your coffee as creamer, in the toast you have, or the cereal you consume. You have it every lunch with your sandwich or burrito and with every dinner with your rolls. I have known several families that would just put a plate of bread on the table every evening. This is the display of addiction, a full out need to satisfy the taste buds by dumping more and more sugar in the body, usually in the form of starchy carbs.

The sad part of this whole argument is that I’ve only covered drugs for diabetes so far. I haven’t even touched on drugs for heart disease, cancer, arthritis, high blood pressure, high cholesterol (probably the most dangerous), chronic pain, hyperlipidemia, obesity, etc, etc. How many side effects do think all these drugs can cause? How many more avenues can this create to develop new drugs to spring upon a mindless public clamoring for the newest relief for their pain?

All of this consumption of the grain industry’s products is what’s driving the pharmaceutical industry today, tomorrow, next year, and for the next 500 and beyond. If we don’t put an end to this now, our society is doomed to suffer the consequences of their carbohydrate addiction, a diet they’re not responsible for. The greed of the grain industry combined with the ambition of the pharmaceutical industry has made us all carboholic slaves to the desires these industries. For me, it’s scary how much power we’ve given these industries, simply because we listen to their advertising. Those who listen to their advertising, and are influenced by it, fall prey to that influence and become their slaves for life or until they quit consuming the grains. There’s very little difference from that of alcoholism.

Anyone who can’t control their emotions entirely by themselves is a slave to their own hormones. Every carboholic is a slave to their emotions and therefore a slave to these industries. The emotions I’m speaking about here are hunger and satiety. You may not classify these emotions, but I submit that they actually are. Satiety is defined as the state of being satisfied. If that is not an emotion, as it expresses feelings of calmness and security, I don’t know what is. Hunger, on the other hand, is defined as a strong desire. Is not that an emotion? These emotions are control by both leptin and Ghrelin, which in turn are controlled by the grain industry, more than anything else. I refuse to take part in this trap anymore.

With emotions being controlled by our hormonal balance like this, how could the influence of anything that modifies that balance, not have an effect on our behavior? It has to. When you combine the drive of an addiction (which is what we’re talking about) with the advertisements promoting that addiction, how can it not have an effect on our health and ultimately our society? That is why I make the statement that this cycle has to change. If it doesn’t cease, our health as a society will never get better.

Let’s go back to addiction, though, for I’m sure you don’t consider this an addiction. I understand, few caught in an addiction can recognize that addiction when they’re feeding it, because the addiction has ways of hiding it. You can ask anyone who has to have at least one beer a day. They’re not addicted to their beer, as far as they’re concerned, yet they have to have it. And often they don’t even drink more than just one. But they still have to have that one. That is what makes it an addiction. The body can and does live much better without beer, so it’s not a substance the body requires to survive. Yet the beer drinker needs that daily beer to satisfy their addiction. To go without, many times causes more problems because of the work your hormones are doing on your emotions and worse yet your actions by controlling how receptors work in your brain. That makes it a natural thing that you need to do, and not an addiction, to appease that desire to drink the beer. This is how addiction works and it happens to carboholics too. I know I am a carboholic. The desire for sweets is still with me. It’s a last refuge of my addiction. It’s something that I get to fight for the rest of my life.

When I think about this I get angry, for I never asked for this nor could I ever wish for it, or wish it upon anyone else. Yet, there is an industry that is committed to not only continuing this pattern, they’re goal is to increase its scope. You can see this in all the advertising.

What do you think they’re advertising when they show you feel good commercials for their soft drinks, fruit drinks, cereals, breads, pastas, pastries, candy, etc, etc? They’re using your emotions to control your behavior. That’s because they can. They already control your hormones and it’s your hormones that control your emotions. Is it any wonder that so many are addicted?

In my estimation, this is criminal behavior. It’s criminal behavior being done on an industrial level. That is why I posted yesterday’s post on our celebration of addiction. They do this because they know that we are addicted by our rate of consumption of their wares. They also know that with their lobbying power, they can get away with virtually anything. It’s kind of the same situation as that of the military-industrial complex. They support congressmen and senators in every state and district, securing their interests, with this influence.

And we allow it to happen, for which we should be ashamed. I am.