Tag Archives: glycation of LDL particles

Carbs and Arthritis

Carbs and Arthritis

Do carbs create arthritis?
You Bet!!

Nothing else in the body creates inflammation, more than carbohydrates in our diet and arthritis is a disease of inflammation.

Carbs are the foundation of inflammation. They are the sole internal source of inflammation. Inflammation wouldn’t even exist  (except for external injuries) without carbohydrates.

Inflammation is caused by glucose and cholesterol coming together and glycating. It happens because of the massive amounts of glucose in the blood. Fat, by itself,  doesn’t cause inflammation. It needs glucose to do that. Protein, by itself, doesn’t cause inflammation. It needs glucose to do so, also.

That makes glucose, the bad actor in this drama, the drama of inflammation in the body and how it’s made. Every manifestation has an equation or a set amount of variables that make up that which is being manifested.

With that said, we’re going to look at the variables that make up the equation of arthritis, the variables that cause inflammation in the body, because after all, arthritis is a disease of inflammation.

Arthritis is the expression of inflammation in the body and it shows up mostly in the joints, first, where movement takes place. That’s because this is where the macrophages get deposited because this is where the blood flows.

There’s another expression of inflammation the body and it’s called a common cold. The funny thing about inflammation is that because it exists everywhere the blood flows, it affects every system in the body. A common cold, for example, expresses itself with inflammation in the sinuses. I know that this may be hard to believe, but if you remove the instigator of inflammation, carbohydrates, a common cold becomes much easier to endure. Actually, common colds are not experienced in people on a ketogenic diet nearly as much s much as they are in carbolic, those on a carbohydrate diet. This is because of the amount of inflammation that carbs cause. Viruses may play a part in the spread of a common cold, but without the glucose in the system, the expression of inflammation can’t take place.  Unfortunately, this can only be proven by elimination carbs from the diet, completely.

It’s basically the same with arthritis, because blood flows throughout the entire body and the inflammation exists in the blood, The inflammation is going to affect every system that blood flows through, including the joints of all limbs.

Before we can continue with arthritis, started we need to know what Wikipedia says about it;

“Arthritis (from Greek arthro-, joint + -itis, inflammation; plural: arthritides) is a form of joint disorder that involves inflammation in one or more joints.[1][2] There are over 100 different forms of arthritis.[3][4] The most common form of arthritis is osteoarthritis (degenerative joint disease), a result of trauma to the joint, infection of the joint, or age. Other arthritis forms are rheumatoid arthritis, psoriatic arthritis, and related autoimmune diseases. Septic arthritis is caused by joint infection.”

If the definition of arthritis is joint inflammation, We already know where inflammation comes from, and it comes from carbohydrates, as explained in Carbs, the New Death SentenceThat makes glucose the bad actor here because without the free glucose roaming through your blood, inflammation wouldn’t exist.

It’s glucose that glycates the unused proteins and fats, by attaching themselves to these cells. The glucose is looking for insulin to turn itself into fat so it can join one of the LDL particles in your blood. if it finds a protein particle or cholesterol particle (almost always LDL particles) to attach itself to, it’ll do so, and this is where the problem of inflammation begins. When this happens, the glucose glycates the cholesterol or protein and its these misshaped proteins and glycated cholesterol that forms plaque and creates inflammation.

This is where I think it gets really interesting, if the lipid that makes up the particle comes from carbohydrates, it attaches itself to an apolipoprotein B and forms LDL cholesterol to be used as fuel for the body.

If the lipid comes from fat, it associates with apolipoprotein A, the foundation of high-density particles or HDL cholesterol. Learn how the HDL and LDL work in your body by reading The value of balancing your cholesterol and The foundations of LDL cholesterol, apolipoprotein B.

It’s the LDL particles that cause most of the damage because of their loose form. Hence the name, low-density lipoprotein. These glycated particles are at the base of over half of all cancers, CVDs, brain damage and arthritis.

According to Wikipedia, “Arthritis is predominantly a disease of the elderly, but children can also be affected by the disease. More than 70% of individuals in North America affected by arthritis are over the age of 65″

This tells me that arthritis is going to happen to everyone on a carbohydrate diet, regardless of how many carbs they consume each day. Remember that 90% of the population is gluten sensitive. This is something that can only be reversed by the industry that feeds us. As long as we have to eat the food they provide us and encourage us to eat, this problem will not subside. It’s in the science, the science of inflammation.

That explains why our addiction to these vile substances must come to an end.
As a society, we need to change this pattern.

The problem of arthritis goes deeper than just inflammation, though, it rides on the amount of vitamin D in the system, as well. vitamin D is crucial to the transport of cholesterol into the cells, so it can be used.

Again, according to Wikipedia;

“Vitamin D refers to a group of fat-soluble secosteroids responsible for enhancing intestinal absorption of calcium, iron, magnesium, phosphate, and zinc. In humans, the most important compounds in this group are vitamin D3 (also known as cholecalciferol) and vitamin D2 (ergocalciferol).[1]

Vitamin D deficiency is more common in people with rheumatoid arthritis than in the general population.[36][37] However, whether vitamin D deficiency is a cause or a consequence of the disease remains unclear.[38] 1α,25-dihydroxyvitamin D3 (1,25D), an active metabolite of vitamin D, affects bone metabolism indirectly through control of calcium and phosphate homeostasis. Interaction between 1,25D and the vitamin D receptor (VDR) affects the production of RANKL and delays osteoclastogenesis.[39] Some trials have found a decreased risk for RA with vitamin D supplementation while others have not.[37]

If Rheumatoid arthritis sufferers have a deficiency of vitamin D in their bodies, that tells me that vitamin D helps to control the expression of Rheumatoid arthritis by allowing the cholesterol particle admittance into the cell so it can be used. (No conductor, no admittance.)

This action prevents the cholesterol from becoming glycated and turned into inflammation because with lower levels of vitamin D in the body, the arthritis is more prevalent. That tells me why lower levels of vitamin D increases Rheumatoid Arthritis. It’s the one-two punch that hits everyone with arthritis; carbs raise LDL particles, raising total cholesterol throwing up flags that cholesterol must be lowered. when that’s the worst thing you can do. Your cholesterol doesn’t need to be lowered (that leads to disease), it needs to be balanced, so you can continue to use your cholesterol to feed your cells the nutrients they need to function properly. See the value of balancing your cholesterol to learn how to balance yours.

Most vitamin D is produced in our skin by ultraviolet rays acting on cholesterol;

“Vitamin D3 is produced photochemically from 7-dehydrocholesterol in the skin of most vertebrate animals, including humans.[106] The precursor of vitamin D3, 7-dehydrocholesterol is produced in relatively large quantities. 7-Dehydrocholesterol reacts with UVB light at wavelengths between 270 and 300 nm, with peak synthesis occurring between 295 and 297 nm.[107] These wavelengths are present in sunlight, as well as in the light emitted by the UV lamps in tanning beds (which produce ultraviolet primarily in the UVA spectrum but typically produce 4% to 10% of the total UV emissions as UVB). Exposure to light through windows is insufficient because glass almost completely blocks UVB light.[108][109]

With vitamin D actually being a fat, in the body, as it comes from cholesterol and cholesterol is made up of lipids, that makes me wonder if it comes from digested fats or ingested fats. A look at 7-dehydrocholesterol revealed nothing as to where it comes from, so I have to be content just knowing it’s a lipid.

Being a lipid gives it access to the cellular structure of all organs, including the skin, bones, and most importantly, your brain. 

This places the importance of vitamin D even higher than what I thought before. Vitamin D is a fat that delivers calcium to your bones, making it that important to bone growth and structure. Yet it’s also important in your brain, where it acts as a conductor for cell signaling proteins, cytokines and adipokines and hormones.

According to Pubmed;
“Vitamin D receptor in the brain

It should be noted that 1,25(OH)2D signaling is conducted through the VDR, which shares its structural characteristics with the broader nuclear steroid receptor family.11 In 1992, Sutherland et al12 provided the first evidence that the VDR is expressed in the human brain. Using radiolabeled complementary deoxyribonucleic acid probes, the authors showed that VDR messenger ribonucleic acid is expressed in the postmortem brains of patients with AD or Huntington’s disease. In a landmark study, Eyles et al13 described that both the VDR and CYP27B1 are widespread in important regions of the human brain including the hippocampus, which is particularly affected by neurodegenerative disorders.1417 Furthermore, the VDR is also expressed in the prefrontal cortex, cingulate gyrus, basal forebrain, caudate/putamen, thalamus, substantia nigra, lateral geniculate nuclei, hypothalamus, and cerebellum.18 Importantly, VDR gene polymorphisms are associated with cognitive decline,19,20 AD,2124 Parkinson’s disease,2529 and multiple sclerosis.30

Showing how important vitamin D is in the brain, it’s become evident that it’s as important as the cell signaling can’t take place efficiently without it, as it’s the conductor. Without enough vitamin D in your system, the conduction is going to be poor, at best. Could it be that this is where cell degradation begins, and inflammation introduces its ugly face? Whether or not it is, we know that vitamin D is crucial for hormones and cell signaling proteins to get their signals through the cell membrane, as that’s what conductors do, they transmit signals.

That tells me, if the pathway is blocked, due to vitamin D deficiency, the cells can’t perform their intended function, because their fuel, lipoproteins can’t get through the cells, due to the lack of a conductor, vitamin D, so they’re left floating around in the blood waiting to be used.

This is where the problem begins because there’s also massive amounts of glucose floating in the blood, waiting to be turned into fat, This gives us the equation that nobody wants, Glucose + cholesterol =  glycation. Glycation is the start is the start of inflammation.

According to PubMed; “Vitamin D lipid-lowering effects appear limited to statin-treated patients and are likely due to decreased cholesterol absorption.” Cholesterol plays a much bigger part in this play than what seemed apparent a few minutes ago. If statin drugs lower total cholesterol and vitamin D, I can only imagine what damage that is reeking on the bodies of those who are condemned to use them. That tells me that those on statin drugs are condemned to more inflammation, more disease, and more arthritis, can this be true?

This is exactly why it’s so important to balance your cholesterol instead of just lowering it. The value of balancing cholesterol tells us that raising HDL cholesterol will help lower LDL cholesterol and control the inflammation by limiting the source of the inflammation, LDL cholesterol. Knowing that raising HDL particles can lower LDL particles help makes it easier to lower LDL particles. Fewer LDL particles in the blood lowers inflammation lessening the effects of arthritis in the body.

Now that we know that, We also know that lowering carb intake lowers LDL cholesterol as it’s carbs that create LDL cholesterol. So curbing carbs, even though it can’t restore, immediately, the damage that’s already been done, it can reverse its current effects, and in the future work to restore at least some of the damage. But it can only restore that which isn’t already too far damaged.

This forces me again to ask, why is this food even on our grocery shelves and why doesn’t it come with a warning?