Tag Archives: neurotoxic

The Quickest Path to All the Diseases of Modern Man

Monsanto’s Clandestine Chemical Terrorism

Would you drink Roundup if you could? Probably not, I least, I wouldn’t. Would you eat something that it’s been doused in? If you knew what it was, you probably wouldn’t touch that either.

Do you realize that every bite of bread you take you’re eating Roundup and massive amounts of it. Every corn chip you eat, you’re eating massive amounts of glyphosate with it. It’s in the nature of how this herbicide is used.

Who knew that our greatest terrorism threat would be a clandestine threat from inside our country and it doesn’t carry a gun or bomb, or any kind of explosives, for that fact. This threat is a completely hidden threat, making it the worst threat we’ve ever faced. This threat is in your diet. It’s in something you eat multiple times a day. In all actuality, your hunger cycle is the instrument of your destruction, with this threat. It’s your hunger cycle that’s locks you into the cycle of destruction that glycation is responsible for as its the glucose that’s responsible for all inflammation, which in turn, is responsible for all modern disease.

All this damage from the enzyme inhibitors in the glyphosate, that’s done to your hormones, is no small matter. These hormones are important hormones affecting digestion, hunger and sleep. (Those are the very same things affected by your diet. also.) Where’s the similarity? It’s explained in the way it affects its targeted enzymes, like tyrosine, tryptophan and phenylalanine. These are all enzymes that influence your hunger, digestion and sleep hormones. If you have problems in any of these areas, this is your answer why.

It involves your consumption of glyphosate. (I’ll bet you didn’t know that, did you?) Would you eat it in the first place, if you knew? You probably would because you’ve been addicted to this substance without you even knowing it. This was literally done right under your nose, when you were fed, as a baby. The industry makes certain that this substance gets into most all baby food. This ensures that you have no choice in this addiction. It ensures your lifetime of compliance in feeding the addiction. It also guarantees your compliance  in the second half of the glucose ruse, the need for pharmaceuticals for a good portion of your life.

This is displayed by all the graphs below as the increase of glyphosate usage mirrors the increase in disease. Are you one of these statistics? If you eat bread, I’m afraid you are.

Targeted enzymes influence the senescence of plants also influence the senescence of your body. They are important enzymes your body uses for digestion and controlling hunger; Glyphosate is absorbed through foliage, and minimally through roots, and transported to growing points. It inhibits a plantenzyme involved in the synthesis of three aromatic amino acidstyrosinetryptophan, and phenylalanine. Therefore, it is effective only on actively growing plants and is not effective as a pre-emergence herbicide. An increasing number of crops have been genetically engineered to be tolerant of glyphosate (e.g. Roundup Ready soybean, the first Roundup Ready crop, also created by Monsanto) which allows farmers to use glyphosate as a post emergence herbicide against weeds. The development of glyphosate resistance in weed species is emerging as a costly problem. While glyphosate and formulations such as Roundup have been approved by regulatory bodies worldwide, concerns about their effects on humans and the environment persist. Many regulatory and scholarly reviews have evaluated the relative toxicity of glyphosate as an herbicide. The German Federal Institute for Risk Assessment toxicology review in 2013 found that “the available data is contradictory and far from being convincing” with regard to correlations between exposure to glyphosate formulations and risk of various cancers, including non-Hodgkin lymphoma (NHL).  A meta-analysis published in 2014 identified an increased risk of NHL in workers exposed to glyphosate formulations. In March 2015 the World Health Organization‘s International Agency for Research on Cancer classified glyphosate as “probably carcinogenic in humans” (category 2A) based on epidemiological studies, animal studies, and in vitro

  • In November, 2015, the European Food Safety Authoritypublished an updated assessment report on glyphosate, concluding that “the substance is unlikely to be genotoxic (i.e. damaging to DNA) or to pose a carcinogenic threat to humans.” Furthermore, the final report clarified that while other, probably carcinogenic, glyphosate-containing formulations may exist, studies “that look solely at the active substance glyphosate do not show this effect. In May 2016, the Joint FAO/WHO Meeting on Pesticide Residues concluded that “glyphosate is unlikely to pose a carcinogenic risk to humans from exposure through the diet”, even at doses as high as 2,000 mg/kg body weight orally.
These targeted enzymes are important for digestion and hunger
  • 1Tyrosineinfluences hunger by controlling enzymes that control how receptors react to stimuli that controls your hunger. Tyrosine is a precursor to Dopamine, your primary hormone influencing hunger. This is the hormone triggered by leptin, your satiety hormone. If it takes more leptin to trigger the dopamine, it’s going to take more food to trigger the leptin. Was this engineered intentionally?
  • 2Tryptophanis also a precursor to serotonin and melatonin. Serotonin is another feel good hormone that’s affected by glyphosate. Melatonin is the hormone that allows you to sleep. without it, you’re going to have trouble sleeping. Is it no wonder why so many people suffer from insomnia now? (They sell medicine for that, don’t they?)
  • 3Phenylalanine Phenylalanine is a precursor for tyrosine; the monoamine neurotransmitters  dopamine,  norepinephrine  (noradrenaline), and epinephrine (adrenaline); and the skin pigment melanin. That was according to Wikipedia. All of those enzymes influence your hunger.

The WHO has finally recognized glyphosate as a Group 2 Carcinogen, meaning that it probably causes cancer. We know that it affects your sleep, hunger and digestion, let’s see if these chemicals can  be responsible for cancer. The evidence for this lies in the multiple graphs showing the increase of glyphosate increasing right alongside the increase of multiple disorders and disease, including autism.

Monsanto’s Glyphosate Ruse

In Monsanto’s desire to spread as much of this on the earth as possible, they’re poisoning every bit of food you eat, unless you grow your own and raise and butcher your own. All forage for feed is sprayed multiple times, maybe even more than the grain used for your bread. Cattle slaughtered for beef, never live long enough to get cancer, yet it goes into their food supply. 1,8 billion lbs in 20 years has been dumped on your food supplies. Ultimately, it goes into your body in multiple avenues, increasing the amount you consume, thereby increasing the amount of enzyme inhibitors affecting your health. This has brought the pharmaceutical industry record profits, not to mention what it’s brought Monsanto and their crop seed companies, pharmaceutical companies, and chemical wing of their manufacturing. Monsanto has engineered clandestine distemper on our health without us even knowing or approving of it.

It’s not been good for the unsuspecting public who are still condemned to eating this food to feed their addiction as evidenced by these studies from PMC;

Glyphosate is a likely cause of the recent epidemic in celiac disease. Glyphosate residues are found in wheat due to the increasingly widespread practice of staging and desiccation of wheat right before harvest. Many of the pathologies associated with celiac disease can be explained by disruption of CYP enzymes. Celiac patients have a shortened life span, mainly due to an increased risk to cancer, most especially non-Hodgkin’s lymphoma, which has also been linked to glyphosate. Celiac disease trends over time match well with the increase in glyphosate usage on wheat crops.

Glyphosate is also neurotoxic. Its mammalian metabolism yields two products: Aminomethylphosphonic acid (AMPA) and glyoxylate, with AMPA being at least as toxic as glyphosate. Glyoxylate is a highly reactive glycating agent, which will disrupt the function of multiple proteins in cells that are exposed. Glycation has been directly implicated in Parkinson’s disease (PD). Glyphosate has been detected in the brains of malformed piglets. In a report produced by the Environmental Protection Agency (EPA), over 36% of 271 incidences involving acute glyphosate poisoning involved neurological symptoms, indicative of glyphosate toxicity in the brain and nervous system.

In the remainder of this paper, we first introduce the link between glyphosate and manganese (Mn) dysbiosis, and briefly describe the main biological roles of Mn. We then describe how glyphosate’s disruption of gut bacteria may be a major player in the recent epidemic in antibiotic resistance. We then explain how glyphosate can influence the uptake of arsenic and aluminum, and propose similar mechanisms at work with Mn. In the next section, we describe how Mn deficiency can lead to a reduction in Lactobacillus in the gut, and we link this to anxiety disorder. We follow with a discussion on mitochondrial dysfunction associated with suppressed Mn superoxide dismutase (Mn-SOD), and then a section on implications of Mn deficiency for oxalate metabolism. The following section explains how Mn deficiency can lead to the overexpression of ammonia and glutamate in many neurological diseases. The next two sections show how Mn accumulation in the liver is linked to cholestasis and high serum low density lipoprotein (LDL), and how this can also induce increased susceptibility to Salmonella poisoning. We then identify a role for Mn in chondroitin sulfate synthesis, and the implications for osteomalacia. The next two sections explain how glyphosate exposure can lead to Mn toxicity in the brain, and discuss two neurological diseases that are associated with excess Mn, PD and prion diseases. After a section on the link between male infertility and Mn deficiency in the testes, we discuss evidence of exposure to glyphosate and end with a short summary of our findings.

The report goes on to detail how this herbicide is involved in suppressing dopamine which leads to an overactive thyroid. It’s also involved in ;

  1. MICROBIAL ANTIBIOTIC INTOLERANCE

Manganese (Mn) is an often overlooked but important nutrient, required in small amounts for multiple essential functions in the body. A recent study on cows fed genetically modified Roundup®-Ready feed revealed a severe depletion of serum Mn. Glyphosate, the active ingredient in Roundup®, has also been shown to severely deplete Mn levels in plants. Here, we investigate the impact of Mn on physiology, and its association with gut dysbiosis as well as neuropathologies such as autism, Alzheimer’s disease (AD), depression, anxiety syndrome, Parkinson’s disease (PD), and prion diseases. Glutamate overexpression in the brain in association with autism, AD, and other neurological diseases can be explained by Mn deficiency. Mn superoxide dismutase protects mitochondria from oxidative damage, and mitochondrial dysfunction is a key feature of autism and Alzheimer’s. Chondroitin sulfate synthesis depends on Mn, and its deficiency leads to osteoporosis and osteomalacia. Lactobacillus, depleted in autism, depend critically on Mn for antioxidant protection. Lactobacillus probiotics can treat anxiety, which is a comorbidity of autism and chronic fatigue syndrome. Reduced gut Lactobacillus leads to overgrowth of the pathogen, Salmonella, which is resistant to glyphosate toxicity, and Mn plays a role here as well. Sperm motility depends on Mn, and this may partially explain increased rates of infertility and birth defects. We further reason that, under conditions of adequate Mn in the diet, glyphosate, through its disruption of bile acid homeostasis, ironically promotes toxic accumulation of Mn in the brainstem, leading to conditions such as PD and prion diseases

  1. MANGANESE DYSBIOSIS DUE TO GLYPHOSATE

Remarkably, Mn deficiency can explain many of the pathologies associated with autism and Alzheimer’s disease (AD). The incidence of both of these conditions has been increasing at an alarming rate in the past two decades, in step with the increased usage of glyphosate on corn and soy crops in the United States, as shown in [Figures 

  1. ANALOGY WITH ARSENIC AND ALUMINUM

Chronic kidney disease is clearly associated with multiple environmental toxicants. There has been an epidemic in recent years in kidney failure among young agricultural workers in Central America, India, and Sri Lanka, particularly those working in the sugar cane fields. A recent paper reached the unmistakable conclusion that glyphosate plays a critical role in this epidemic. A growing practice of spraying sugar cane with glyphosate as a ripener and desiccant right before the harvest has led to much greater exposure to the workers in the fields. The authors, who focused their studies on affected workers in rice paddies in Sri Lanka, identified a synergistic effect of arsenic, which contaminated the soil in the affected regions. This paper is highly significant, because it proposes a mechanism whereby glyphosate greatly increases the toxicity of arsenic through chelation, which promotes uptake by the gut. Glyphosate also depletes glutathione (GSH) and glutathione S transferase (GST) is a critical enzyme for liver detoxification of arsenic. As a consequence, excess arsenic in the kidney causes acute kidney failure, without evidence of other symptoms such as diabetes usually preceding kidney failure.

  1. ANALOGY WITH ARSENIC AND ALUMINUM
  2. MN-SUPEROXIDE DISMUTASE AND MITOCHONDRIAL DYSFUNCTION
  3. GUT BACTERIA DYSBIOSIS AND ANXIETY
  4. AMMONIA, GLUTAMATE, AND NEUROTOXICITY

In this section, we will show that both glutamate and ammonia are implicated as neurotoxins in connection with autism and other neurological diseases, and we will offer the simple explanation that Mn deficiency leads to impaired activity of glutamine synthase and arginase, both of which utilize Mn as a cofactor. Mn deficiency can also explain the increased risk to epilepsy found in autism, due to the fact that Mn decreases T2 relaxation time. Mn-deprived rats are more susceptible to convulsions.

Many diseases and conditions are currently on the rise in step with glyphosate usage in agriculture, particularly on GM crops of corn and soy. These include autism, AD, PD, anxiety disorder, osteoporosis, inflammatory bowel disease, renal lithiasis, osteomalacia, cholestasis, thyroid dysfunction, and infertility. All of these conditions can be substantially explained by the dysregulation of Mn utilization in the body due to glyphosate.

It may seem implausible that glyphosate could be toxic to humans, given the fact that government regulators appear nonchalant about steadily increasing residue limits, and that the levels in food and water are rarely monitored by government agencies, presumably due to lack of concern. However, a paper by Antoniou et al. provided a scathing indictment of the European regulatory process regarding glyphosate’s toxicity, focusing on potential teratogenic effects. They identified several key factors leading to a tendency to overlook potential toxic effects. These include using animal studies that are too short or have too few animals to achieve statistical significance, disregarding in vitro studies or studies with exposures that are higher than what is expected to be realistically present in food, and discarding studies that examine the effects of glyphosate formulations rather than pure glyphosate, even though formulations are a more realistic model of the natural setting and are often orders of magnitude more toxic than the active ingredient in pesticides. Regulators also seemed unaware that chemicals that act as endocrine disruptors (such as glyphosate often have an inverted dose–response relationship, wherein very low doses can have more acute effects than higher doses. Teratogenic effects have been demonstrated in human cell lines. An in vitro study showed that glyphosate in parts per trillion can induce human breast cancer cell proliferation.

  1. PARKINSON’S DISEASE
  2. PRION DISEASES
  3. OSTEOMALACIA AND ARTHRITIS

This is only a partial list of what this herbicide is responsible for. Visit the link at the head of this section for the full story. You should visit it, if only for your health’s concern. This just points out the fact that what you eat has more impact on your health than anything else. It would be nice if you could get away from it, but you can’t. The pollution is everywhere you go for food. You have to produce your own food to be completely free from this curse.

It’s cursing you not only through the grains you eat, but through the damage done to feed crops, contaminating beef, pork, chicken, turkey and even dairy cows, poisoning even the cheese, milk and butter you buy. The only way you can get round this ruse is to grow your own food and raise and butcher your own meat. Monsanto has every other path sewn up, tighter than a drum. To eat grains is to court death. It’s become that simple.

  • Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance

Celiac disease, and, more generally, gluten intolerance, is a growing problem worldwide, but especially in North America and Europe, where an estimated 5% of the population now suffers from it. Symptoms include nausea, diarrhea, skin rashes, macrocytic anemia and depression. It is a multifactorial disease associated with numerous nutritional deficiencies as well as reproductive issues and increased risk to thyroid disease, kidney failure and cancer. Here, we propose that glyphosate, the active ingredient in the herbicide, Roundup®, is the most important causal factor in this epidemic. Fish exposed to glyphosate develop digestive problems that are reminiscent of celiac disease. Celiac disease is associated with imbalances in gut bacteria that can be fully explained by the known effects of glyphosate on gut bacteria. Characteristics of celiac disease point to impairment in many cytochrome P450 enzymes, which are involved with detoxifying environmental toxins, activating vitamin D3, catabolizing vitamin A, and maintaining bile acid production and sulfate supplies to the gut. Glyphosate is known to inhibit cytochrome P450 enzymes. Deficiencies in iron, cobalt, molybdenum, copper and other rare metals associated with celiac disease can be attributed to glyphosate’s strong ability to chelate these elements. Deficiencies in tryptophan, tyrosine, methionine and selenomethionine associated with celiac disease match glyphosate’s known depletion of these amino acids. Celiac disease patients have an increased risk to non-Hodgkin’s lymphoma, which has also been implicated in glyphosate exposure. Reproductive issues associated with celiac disease, such as infertility, miscarriages, and birth defects, can also be explained by glyphosate. Glyphosate residues in wheat and other crops are likely increasing recently due to the growing practice of crop desiccation just prior to the harvest. We argue that the practice of “ripening” sugar cane with glyphosate may explain the recent surge in kidney failure among agricultural workers in Central America. We conclude with a plea to governments to reconsider policies regarding the safety of glyphosate residues in foods.

  • Gut bacteria

We then show that glyphosate is associated with an overgrowth of pathogens along with an inflammatory bowel disease in animal models. A parallel exists with celiac disease where the bacteria that are positively and negatively affected by glyphosate are overgrown or underrepresented respectively in association with celiac disease in humans.

  • CYP Enzyme impairment and sulfate depletion
  • Retinoic acid, celiac disease and reproductive issues
  • Anemia and iron

Glyphosate’s chelating action can have profound effects on iron in plants (Eker et al.2006; Bellaloui et al.2009). Glyphosate interferes with iron assimilation in both glyphosate-resistant and glyphosate-sensitive soybean crops (Bellaloui et al.2009). It is therefore conceivable that glyphosate’s chelation of iron is responsible for the refractory iron deficiency present in celiac disease.

  • Molybdenum deficiency
  • Selenium and thyroid disorders
  • Indole and kidney disease
  • Nutritional deficiencies

Glyphosate disrupts the synthesis of tryptophan and tyrosine in plants and in gut bacteria, due to its interference with the shikimate pathway (Lu et al.2013; María et al., 1996), which is its main source of toxicity to plants. Glyphosate also depletes methionine in plants and microbes. A study on serum tryptophan levels in children with celiac disease revealed that untreated children had significantly lower ratios of tryptophan to large neutral amino acids in the blood, and treated children also had lower levels, but the imbalance was less severe (Hernanz & Polanco, 1991). 

  • Cancer

Chronic inflammation, such as occurs in celiac disease, is a major source of oxidative stress, and is estimated to account for 1/3 of all cancer cases worldwide (Ames et al.1993; Coussens & Werb, 2002). Oxidative stress leads to DNA damage and increased risk to genetic mutation. Several population-based studies have confirmed that patients with celiac disease suffer from increased mortality, mainly due to malignancy (Nielsen et al.1985; Logan et al.1989; Pricolo et al.1998; Cottone et al.1999; Corrao et al.2001; Green et al.2003). These include increased risk to non-Hodgkin’s lymphoma, adenocarcinoma of the small intestine, and squamous cell carcinomas of the esophagus, mouth, and pharynx, as well as melanoma. The non-Hodgkin’s lymphoma was not restricted to gastrointestinal sites, and the increased risk remained following a gluten-free diet (Green et al.2003).

  • Proposed transglutaminase-glyphosate interactions
  • Evidence of glyphosate exposure in humans and animals
  • Kidney disease in agricultural workers

In another study in the PMC database of over 164 studies done on this subject;

Biochemical analyses confirmed very significant chronic kidney deficiencies, for all treatments and both sexes; 76% of the altered parameters were kidney-related. In treated males, liver congestions and necrosis were 2.5 to 5.5 times higher. Marked and severe nephropathies were also generally 1.3 to 2.3 times greater. In females, all treatment groups showed a two- to threefold increase in mortality, and deaths were earlier. This difference was also evident in three male groups fed with GM maize. All results were hormone- and sex-dependent, and the pathological profiles were comparable. Females developed large mammary tumors more frequently and before controls; the pituitary was the second most disabled organ; the sex hormonal balance was modified by consumption of GM maize and Roundup treatments. Males presented up to four times more large palpable tumors starting 600 days earlier than in the control group, in which only one tumor was noted. These results may be explained by not only the non-linear endocrine-disrupting effects of Roundup but also by the overexpression of the EPSPS transgene or other mutational effects in the GM maize and their metabolic consequences.

 

Our findings show that the differences in multiple organ functional parameters seen from the consumption of NK603 GM maize for 90 days escalated over 2 years into severe organ damage in all types of test diets. This included the lowest dose of R administered (0.1 ppb, 50 ng/L G equivalent) of R formulation administered, which is well below permitted MRLs in both the USA (0.7 mg/L) and European Union (100 ng/L). Surprisingly, there was also a clear trend in increased tumor incidence, especially mammary tumors in female animals, in a number of the treatment groups. Our data highlight the inadequacy of 90-day feeding studies and the need to conduct long-term (2 years) investigations to evaluate the life-long impact of GM food consumption and exposure to complete pesticide formulations.

Tumors are reported in line with the requirements of OECD chronic toxicity protocols 452 and 453, which require all ‘lesions’ (which by definition include tumors) to be reported. These findings are summarized in Figure 4. The results are presented in the form of real-time cumulative curves (each step corresponds to an additional tumor in the group). Only the growing largest palpable growths (above a diameter of 17.5 mm in females and 20 mm in males) are presented (for example, see Figure 5A,B,C). These were found to be in 95% of cases non-regressive tumors (Figure 5D,E,F,G,H,I,J) and were not infectious nodules. These arose from time to time; then, most often disappeared and were not different from controls after bacterial analyses. The real tumors were recorded independently of their grade, but dependent on their morbidity, since non-cancerous tumors can be more lethal than those of cancerous nature, due to internal hemorrhaging or compression and obstruction of function of vital organs, or toxins or hormone secretions. These tumors progressively increased in size and number, but not proportionally to the treatment dose, over the course of the experiment (Figure 4). As in the case of rates of mortality (Figure 6), this suggests that a threshold in effect was reached at the lower doses. Tumor numbers were rarely equal but almost always more than in controls for all treated groups, often with a two- to threefold increase for both sexes. Tumors began to reach a large size on average 94 days before controls in treated females and up to 600 days earlier in two male groups fed with GM maize (11 and 22% with or without R).

  • Glyphosateformulations induce apoptosis and necrosis in human umbilical, embryonic, and placental cells.

We have evaluated the toxicity of four glyphosate (G)-based herbicides in Roundup formulations, from 10(5) times dilutions, on three different human cell types. This dilution level is far below agricultural recommendations and corresponds to low levels of residues in food or feed. The formulations have been compared to G alone and with its main metabolite AMPA or with one known adjuvant of R formulations, POEA. HUVEC primary neonate umbilical cord vein cells have been tested with 293 embryonic kidney and JEG3 placental cell lines. All R formulations cause total cell death within 24 h, through an inhibition of the mitochondrial succinate dehydrogenase activity, and necrosis, by release of cytosolic adenylate kinase measuring membrane damage. They also induce apoptosis via activation of enzymatic caspases 3/7 activity. This is confirmed by characteristic DNA fragmentation, nuclear shrinkage (pyknosis), and nuclear fragmentation (karyorrhexis), which is demonstrated by DAPI in apoptotic round cells. G provokes only apoptosis, and HUVEC are 100 times more sensitive overall at this level. The deleterious effects are not proportional to G concentrations but rather depend on the nature of the adjuvants. AMPA and POEA separately and synergistically damage cell membranes like R but at different concentrations. Their mixtures are generally even more harmful with G. In conclusion, the R adjuvants like POEA change human cell permeability and amplify toxicity induced already by G, through apoptosis and necrosis. The real threshold of G toxicity must take into account the presence of adjuvants but also G metabolism and time-amplified effects or bioaccumulation. This should be discussed when analyzing the in vivo toxic actions of R. This work clearly confirms that the adjuvants in Roundup formulations are not inert. Moreover, the proprietary mixtures available on the market could cause cell damage and even death around residual levels to be expected, especially in food and feed derived from R formulation-treated crops.

This poses a major question in my mind; can the target in this ruse, be you and your money? It’s obviously what the end result is and that’s displayed in the record profits of the pharmaceutical industry. The more disease caused by this herbicide, the more medicine the pharmaceutical industry sells. Monsanto owns the crop seed companies, produces the herbicide and owns the pharmaceutical corporations, so they’re profiting much more than two or three times in this ruse. It’s that simple. Only you can control this transformation of your health, this travesty of justice. Only you can say no to the grains that this herbicide poisons. It’s your choice to remain a slave to Monsanto, or be free. All you have to do is to give up the grains.

THERE’S MORE DANGER IN YOUR FOOD

THAT LURKS BEHIND WHAT’S SOLD AS GOOD

YOU’RE ENCOURAGED TO EAT WHAT’S WRONG

TO MAKE A CERTAIN INDUSTRY STRONG

THAT DOESN’T NEED YOUR HELP TO SURVIVE

YET COULD COST EVERYONE THEIR LIVES

UNLESS YOU HAVE THE POWER TO WAKE UP

YOUR FATE IS SEALED WITHIN THIS MAKE UP